Effect of Iron Therapy on Platelet Counts in Patients with Inflammatory Bowel Disease-Associated Anemia

Secondary thrombocytosis is a clinical feature of unknown significance. In inflammatory bowel disease (IBD), thrombocytosis is considered a marker of active disease; however, iron deficiency itself may trigger platelet generation. In this study we tested the effect of iron therapy on platelet counts in patients with IBD-associated anemia.Platelet counts were analyzed before and after iron therapy from four prospective clinical trials. Further, changes in hemoglobin, transferrin saturation, ferritin, C-reactive protein, and leukocyte counts, before and after iron therapy were compared. In a subgroup the effect of erythropoietin treatment was tested. The results were confirmed in a large independent cohort (FERGIcor).A total of 308 patient records were available for the initial analysis. A dose-depended drop in platelet counts (mean 425 G/L to 320 G/L; p<0.001) was found regardless of the type of iron preparation (iron sulphate, iron sucrose, or ferric carboxymaltose). Concomitant erythropoietin therapy as well as parameters of inflammation (leukocyte counts, C-reactive protein) had no effect on the change in platelet counts. This effect of iron therapy on platelets was confirmed in the FERGIcor study cohort (n=448, mean platelet counts before iron therapy: 383 G/L, after: 310 G/L, p<0.001).Iron therapy normalizes elevated platelet counts in patients with IBD-associated anemia. Thus, iron deficiency is an important pathogenetic mechanism of secondary thrombocytosis in IBD

Leistungskriterien fuer biologische Abluftreinigungsanlagen. Teilprojekt: Entwicklung eines neuen Verfahrens zur biologischen Abluftreinigung: Reaktor mit kontrollierter Bewegung der Traegerkoerper fuer den Biofilm Abschlussbericht

Im Rahmen des vorliegenden Forschungsprojektes wurden verschiedene Verfahren zur biologischen Abluftreinigung entwickelt, die die bekannten Nachteile der schlechten Bewaeltigung von Belastungsspitzen und geringen Standzeiten bei Rieselbettreaktoren und Biowaeschern vermeiden. Das Zuwachsen der Rieselbettreaktoren kann verhindert werden, so dass ein langzeitstabiler, effizienter und zuverlaessiger Betrieb moeglich ist und der Druckverlust erheblich reduziert wird. Beim Biowaescher werden durch ein neues Reaktorkonzept grosse umzupumpende Fluessigkeitsmengen vermieden und hohe Biomassekonzentrationen etabliert. (orig.)New techniques for biological exhaust purification were developed which avoid the known shortcomings of trickle bed reactors and biological washers, i.e. the inability to cope with load peaks and short life. Depositions on trickle bed reactors can be prevented, so that efficient, reliable and long-term operation will be possible at much lower pressure loss. In the case of the biological washer, a new reactor concept avoids large liquid volums and high biomass concentrations.Available from TIB Hannover: F01B1023 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDeutsche Bundesstiftung Umwelt, Osnabrueck (Germany)DEGerman