Manual / Issue 6 / Assemblage

Manual, a journal about art and its making. Assemblage. The sixth issue. An assemblage is both an act and a result-the work of gathering and conjoining as well as the state of having been gathered and conjoined. This issue of Manual pieces together works made out of practical necessity and others that marry dazzling embellishments for optimal effect, examining how history (or one version of it) was (and is) pastiched from disparate sources, how fashionable textile samples were collected, and more (always more). An assembly of assemblages, an assortment of intended and unintended interrelationships, Manual issue six is the sum of its parts and the parts themselves, a dynamic gathering of artists and authors, objects and interpretations, mash-ups and remixes, lemons and lightbulbs, vibrantly inter-animating each other. Softcover, 68 pages. Published 2016 by the RISD Museum. Manual 6 (Assemblage) contributors include Eric Anderson, Taylor Elyse Anderson, Bob Dilworth, Christina Hemauer, Roman Keller, Mariani Lefas-Tetenes, Simone Leigh, Leora Maltz-Leca, Ingrid A. Neuman, Tara Nummedal, Todd Oldham, and Britany Salsbury.https://digitalcommons.risd.edu/risdmuseum_journals/1032/thumbnail.jp

Enhanced Brain Disposition and Effects of Δ9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice

The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ9-tetrahydrocannabinol (THC) has affinity for P-gp and Bcrp, however it is unknown whether these transporters modulate the brain accumulation of THC and its functional effects on the CNS. Here we aim to show that mice devoid of Abcb1 and Abcg2 retain higher brain THC levels and are more sensitive to cannabinoid-induced hypothermia than wild-type (WT) mice. Abcb1a/b (−/−), Abcg2 (−/−) and wild-type (WT) mice were injected with THC before brain and blood were collected and THC concentrations determined. Another cohort of mice was examined for THC-induced hypothermia by measuring rectal body temperature. Brain THC concentrations were higher in both Abcb1a/b (−/−) and Abcg2 (−/−) mice than WT mice. ABC transporter knockout mice exhibited delayed elimination of THC from the brain with the effect being more prominent in Abcg2 (−/−) mice. ABC transporter knockout mice were more sensitive to THC-induced hypothermia compared to WT mice. These results show P-gp and Bcrp prolong the brain disposition and hypothermic effects of THC and offer a novel mechanism for both genetic vulnerability to the psychoactive effects of cannabis and drug interactions between CNS therapies and cannabis

Seroprevalence of parvovirus B19 NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women

Parvovirus B19 is the causative agent of erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. These include acute and chronic arthritis, hydrops fetalis in pregnant women, aplastic anemia, and thrombocytopenia. The host's immune response is directed against the viral structural proteins VP1 and VP2. This study investigated the presence of IgG against the viral nonstructural protein NS1 using Western blot. Serum panels from healthy individuals, B19-infected pregnant women, and various disease groups were tested. The disease groups included patients with symptoms that may be linked to parvovirus B19 infection. The results showed that IgG against the NS1 protein was present in 22% of healthy individuals with past B19 infection. In cases of persistent or prolonged B19 infections, the prevalence of NS1-specific antibodies was as high as 80%. It is concluded that NS1-specific IgG may be used as an indicator of chronic or more severe courses of parvovirus B19 infections

Bromine Adsorption and Thermal Stability on Rh 111 A Combined XPS, LEED and DFT Study

This study addresses a fundamental question in surface science the adsorption of halogens on metal surfaces. Using synchrotron radiation based high resolution X ray photoelectron spectroscopy XPS , temperature programmed XPS, low energy electron diffraction LEED and density functional theory DFT calculations, we investigated the adsorption and thermal stability of bromine on Rh 111 in detail. The adsorption of elemental bromine on Rh 111 at 170 amp; 8197;K was followed in amp; 8197;situ by XPS in the Br 3d region, revealing two individual, coverage dependent species, which we assign to fcc hollow and bridge bound atomic bromine. In addition, we find a significant shift in binding energy upon increasing coverage due to adsorbate adsorbate interactions. Subsequent heating shows a high thermal stability of bromine on Rh 111 up to above 1000 amp; 8197;K, indicating strong covalent bonding. To complement the XPS data, LEED was used to study the long range order of bromine on Rh 111 we observe a amp; 8730;3 amp; 8730;3 R30 structure for low coverages amp; 8804;0.33 amp; 8197;ML and a star shaped compression structure for higher coverages 0.33 0.43 amp; 8197;ML . Combining LEED and DFT calculations, we were able to visualize bromine adsorption on Rh 111 in real space for varying coverages