Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation

In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours’ limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations

Making Peace in an Age of War: Emperor Ferdinand III (1608–1657)

This English-language translation of Mark Hengerer\u27s Kaiser Ferdinand III: 1608–1657 Eine Biographie is based on an analysis of the weekly reports sent by the papal nuncio’s office to the Vatican. These reports give detailed information about the daily whereabouts of the dynasty, courtiers, and foreign visitors, and they contain the gossip of the court in addition to weekly analysis of some political problems. This material enabled the author to report on daily life of the dynasty and to analyze the circumstances under which policy was made, which has led to a balance between the personality of Ferdinand III and the problems with which he dealt. In this biography, Hengerer provides answers to the question: Why did it take the emperor more than ten years to end a devastating war, the traumatizing effects of which on central Europe lasted into the twentieth century, particularly since there was no hope of victory against his foreign adversaries from the very moment he came into power?https://docs.lib.purdue.edu/purduepress_previews/1040/thumbnail.jp

Judgments of Learning and Retrospective Confidence Judgments: A Qualitative Exploration of Difference in Processes

Many studies of metamemorial confidence have found differences in calibration and resolution between two similar confidence judgments – judgments of learning (JOLs) and retrospective confidence judgments (RCJs). These findings have led to competing theories of the processes involved in JOLs and RCJs, and whether they make use of the same processes or different processes. This study critically tested two such explanations for JOLs and RCJs – the dual process descriptive model of confidence and the target accessibility model of confidence. Participants provided written justifications of their metamemorial confidence judgments for JOLs and RCJs for unrelated word-pairs. Justifications were analyzed using three different but complementary text data analyses – Latent semantic analysis, n-gram word frequency analysis, and support vector machine analysis – to determine whether both JOLs and RCJs utilize the dual process descriptive method, or if RCJs instead only utilize target accessibility. Results indicated that both JOL and RCJ justifications are characterized by a cue-familiarity check at lower levels of confidence and increasing amounts of partial target information as confidence increases. These findings support the dual process descriptive model of confidence, a model that states that confidence judgments are comprised of a cue-familiarity check followed by a retrieval attempt and associated partial target information. Additionally, results indicated that RCJ justifications made greater use of cue-based information than they did target-based information. This finding challenges theories that RCJs only utilize target accessibility as the source of metamemorial confidence and suggests other processes are involved

Making Peace in an Age of War

This English-language translation of Mark Hengerer's Kaiser Ferdinand III: 1608–1657 Eine Biographie is based on an analysis of the weekly reports sent by the papal nuncio’s office to the Vatican. These reports give detailed information about the daily whereabouts of the dynasty, courtiers, and foreign visitors, and they contain the gossip of the court in addition to weekly analysis of some political problems. This material enabled the author to report on daily life of the dynasty and to analyze the circumstances under which policy was made, which has led to a balance between the personality of Ferdinand III and the problems with which he dealt. In this biography, Hengerer provides answers to the question: Why did it take the emperor more than ten years to end a devastating war, the traumatizing effects of which on central Europe lasted into the twentieth century, particularly since there was no hope of victory against his foreign adversaries from the very moment he came into power