Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment with a combination of simvastatin solution (2.2 mg/50 &#956;l) and DBBM (DBBMSIM-1); and treatment with simvastatin solution (0.5 mg/50 &#956;l) and DBBM (DBBMSIM-2). Animals were sacrificed on postoperative day 30 or 60, after which the calvariae were X-rayed and prepared for histomorphometric evaluation. The data were submitted to statistical analysis (p < 0.05). X-rays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and DBBM group samples. Histomorphometric analysis revealed that, on postoperative day 30, both DBBM and DBBMSIM-1 had a negative impact on bone formation. On postoperative day 60, none of the combinations tested impaired bone repair. These results showed that the association between DBBM and simvastatin had a negative impact on bone repair

Pool of bovine morphogenetic proteins and guided tissue regeneration in the treatment of intrabony periodontal defects: I- Clinical measurements ''Pool'' de proteínas morfogenéticas bovinas no tratamento de defeitos periodontais intra-ósseos: I- Medidas clínicas

The purpose of this study was to evaluate the effect of the pool of bovine BMPs on the treatment of intrabony defects. The sample comprised 15 patients aged 26 to 57 years old presenting with 10 pairs of lesions of 2 or 3 walls or 2-3 walls ³5mm, located in the same type teeth (premolar or molar) and same jaw. The test defects were treated with combination of a pool of bovine bone morphogenetic and resorbable hydroxyapatite carrier (BMPs- HA), bovine demineralized bone matrix (MB) and coverage by a bovine collagen barrier membrane. The control defects were treated with MB-HA and covered by a bovine collagen membrane. The clinical measurements at six months after therapy in the test group revealed a reduction in the mean probing pocket depth (PPD) of 1.63 ± 1.41mm (B) and 1.93 ± 0.96mm (L) and a mean change in the clinical attachment level (CAL) of 1.60 ± 1.16mm (B) and 1.46 ± 0.97mm (L). The control group showed a mean reduction of PPD of 1.93 ± 1.34mm (B) and 2.0 ± 1.51mm (L) and a mean change of CAL of 1.03 ± 1.24mm (B) and 1.30 ± 1.14 mm (L). The analysis of variance (ANOVA) demonstrated that the changes in the clinical parameters were statistically significant (p<0.05). There were no significant differences between the test and controls subjects (Student's test, p<0.005). These findings suggest that the use of a pool of bovine BMPs do not provide added effects to GTR in the treatment of intrabony defects.<br>Este estudo teve como objetivo avaliar a aplicação do ''pool'' de BMPs bovinas no tratamento de defeitos intra-ósseos. A amostra constou de quinze indivíduos com idade entre 26 e 57 anos, apresentando um par de defeitos intra-ósseos comparáveis, localizados no mesmo arco em dentes do mesmo tipo (pré-molares ou molares) e com perda de inserção (PI) ³5mm. Em cada indivíduo, o defeito teste foi tratado com a associação ''pool'' de BMPs- carreador Hidroxiapatita reabsorvível (BMPs-HA), matriz orgânica bovina desmineralizada liofilizada (MO) e barreira de colágeno bovino, enquanto os defeitos controle foram tratados com MO-HA e barreira de colágeno. Na avaliação clínica aos seis meses após a medida inicial, o grupo teste apresentou variação de profundidade de sondagem (PS) de -1,63mm ± 1,141 na vestibular (V) e -1,93mm ± 0,961 na lingual (L) e variação do nível de inserção (NI) de -1,60mm ± 1,168 na V e -1,46mm ± 0,972 na L. O grupo controle apresentou variação de PS de -1,93mm ± 1,347 (V) e -2,0mm ± 1,511 (L) e variação de NI de -1,03mm ± 1,245 (V) e -1,30mm ± 1,114 (L). A análise de variância indicou que a variação de PS e NI foi significativa em ambos os grupos (p<0,05). Entretanto, de acordo com o teste t não houve diferença significativa entre os grupos quanto à variação PS e NI (p<0,05). Em conclusão, a aplicação do ''pool'' de BMPs não oferece benefícios adicionais ao tratamento de defeitos intra-ósseos

Conhecimentos produzidos acerca do crack: uma incursão nas dissertações e teses brasileiras Knowledge derived from studies on crack: an incursion into Brazilian dissertations and theses

Trata-se de um estudo do tipo revisão sistemática, com base na modalidade revisão integrativa, que objetivou analisar as características do conhecimento produzido sobre o crack pelos cursos de mestrado e doutorado brasileiros. O corpus de investigação foi composto por 33 trabalhos (18 dissertações e 15 teses), sendo que 51,5% dos estudos pertencem à área das Ciências da Saúde, com destaque para o Programa de Pós-Graduação de Psiquiatria (e Psicologia Médica) que produziu cinco dissertações/teses. Os saberes acerca da epidemia são oriundos, em sua maioria (51,5%), da Universidade Federal de São Paulo e da Universidade de São Paulo, tendo a região Sudeste concentrado 81,8% dos estudos. As temáticas mais investigadas foram: alterações orgânicas, tráfico de drogas e consumo de crack, HIV/aids, e modelos e estratégias de tratamento. Concluiu-se que o conhecimento "stricto sensu" brasileiro sobre o crack é ainda incipiente, pontual e pouco resolutivo, embora promissor frente às demandas e implicações que esta epidemia impõe à sociedade.<br>This is a systematic review based on the integrative review method, which sought to analyze the characteristics of knowledge produced by studies on crack, in Brazilian Master's and Doctoral courses. The investigation comprised 33 studies (18 dissertations and 15 theses). Among them, 51.5% were from the Health Science area with emphasis on the Postgraduate Program in Psychiatry (and Medical Psychology), which provided five dissertations/theses. Most of the knowledge on the epidemic (51.5%) are from the Universidade Federal de São Paulo and Universidade de São Paulo, with the largest number of studies (81.8%) concentrated in the southeast. The themes most analyzed were: organic alterations, drug trafficking and crack use, HIV/Aids, types and strategies of treatment. The results showed that Brazilian stricto sensu knowledge about crack is still incipient, sketchy and ineffectual, albeit promising due to demands and implications that this epidemic imposes upon society