Gebäudemodernisierung vorgefertigt

Mit TES-EnergyFacade (Timber Element System) wurde die bestehende Technologie des Bauens mit hochgradig vorgefertigten Holzelementen für die industrielle Nachrüstung von Gebäuden vor über 15 Jahren entwickelt. Seit 2006 hat Prof. Stefan Winter zusammen mit einem Netzwerk von Forschungsinstituten und Holzbaubetrieben die Technologie in engem Kontakt mit der Praxis und realen Projekten weiterentwickelt. Ausgehend von den grundlegenden Ideen für die Verbindung und Anbringung einer neuen Hülle an einem veralteten Gebäude im ersten Projekt im Jahr 2008 wurden nach und nach neue Merkmale und Funktionen hinzugefügt, um einen Mehrwert zu schaffen und eine ganzheitlichere Lösung für die Modernisierung des Gebäudebestands zu erreichen. Heute ist die Relevanz der Aufgabe noch größer als zu der Zeit, als die TES-Technologie zum ersten Mal erdacht wurde. Der Gebäudebestand der Nachkriegszeit veraltet zusehends und mit ihm große Teile der europäischen Metropolen. Aufgrund der in diesen Jahrzehnten errichteten baulichen und architektonischen Typen bieten sich interessante Holzbaulösungen an. Zusammen mit vertikalen und horizontalen Raumerweiterungen können hochgradig vorgefertigte Holztafelbauhüllen die Tektonik und Funktionalität bestehender Fassaden verändern. TES ist zu einem Planungsinstrumentarium geworden, mit dem der vorhandene Gebäudebestand auf radikale Weise überdacht, umgestaltet oder neu gebaut werden kann und kreislaufgerecht den Lebenszyklus der Gebäude dauerhaft verlängert.Building retrofitting with prefabricated timber elements with TES-EnergyFacade (Timber Element System), the existing technology of building with highly prefabricated timber elements for the industrial retrofitting of buildings was developed over 15 years ago. Since 2006, Prof Dr Stefan Winter, together with a network of research institutes and timber construction companies, has further developed and refined the technology in close contact with practice and real projects. Starting from the basic ideas for connecting and attaching a new envelope to an outdated building in the first project in 2008, new features and functions were gradually added to create added value and achieve a more holistic solution for the modernisation of existing buildings. Today, the relevance of the task is even greater than it was when TES technology was first conceived. The post-war building stock is becoming increasingly outdated and with it large parts of Europe’s metropolises. The structural and architectural types built in these decades offer interesting timber construction solutions. Together with vertical and horizontal room extensions, highly prefabricated timber panelised building envelopes can change the tectonics and functionality of existing façades. TES has become a planning tool with which the existing building stock can be radically rethought, remodelled or rebuilt, extending the life cycle of buildings in the long term

Triggering Enzymatic Activity with Force

Integrating single molecule force spectroscopy with fluorescence-based techniques allows the manipulation of an enzyme with a periodic stretching and relaxation protocol while simultaneously monitoring its catalytic activity. After releasing the stretching force we observe a higher probability for enzymatic activity at a time of 1.7 s. A detailed theoretical analysis reveals that the relaxation from the force-induced enzyme conformation to the observed active conformation follows a cascade reaction with several steps and a free energy difference of at least 8 kBT. Our study clearly points out the direct influence of force on enzymatic activity and opens up a new way to study and manipulate (bio)catalytic reactions at the single molecule level

Triggering Enzymatic Activity with Force

Integrating single molecule force spectroscopy with fluorescence-based techniques allows the manipulation of an enzyme with a periodic stretching and relaxation protocol while simultaneously monitoring its catalytic activity. After releasing the stretching force we observe a higher probability for enzymatic activity at a time of 1.7 s. A detailed theoretical analysis reveals that the relaxation from the force-induced enzyme conformation to the observed active conformation follows a cascade reaction with several steps and a free energy difference of at least 8 kBT. Our study clearly points out the direct influence of force on enzymatic activity and opens up a new way to study and manipulate (bio)catalytic reactions at the single molecule level

Triggering Enzymatic Activity with Force

Integrating single molecule force spectroscopy with fluorescence-based techniques allows the manipulation of an enzyme with a periodic stretching and relaxation protocol while simultaneously monitoring its catalytic activity. After releasing the stretching force we observe a higher probability for enzymatic activity at a time of 1.7 s. A detailed theoretical analysis reveals that the relaxation from the force-induced enzyme conformation to the observed active conformation follows a cascade reaction with several steps and a free energy difference of at least 8 kBT. Our study clearly points out the direct influence of force on enzymatic activity and opens up a new way to study and manipulate (bio)catalytic reactions at the single molecule level

Otl Aicher : Designer. Typograf. Denker. /

Biografie - Werk, Werdegang und Wirkung.Biografie - Werk, Werdegang und Wirkung

The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction – a phase III trial of the German AIO/CAO-V/CAOGI

Abstract Background Historical data indicate that surgical resection may benefit select patients with metastatic gastric and gastroesophageal junction cancer. However, randomized clinical trials are lacking. The current RENAISSANCE trial addresses the potential benefits of surgical intervention in gastric and gastroesophageal junction cancer with limited metastases. Methods This is a prospective, multicenter, randomized, investigator-initiated phase III trial. Previously untreated patients with limited metastatic stage (retroperitoneal lymph node metastases only or a maximum of one incurable organ site that is potentially resectable or locally controllable with or without retroperitoneal lymph nodes) receive 4 cycles of FLOT chemotherapy alone or with trastuzumab if Her2+. Patients without disease progression after 4 cycles are randomized 1:1 to receive additional chemotherapy cycles or surgical resection of primary and metastases followed by subsequent chemotherapy. 271 patients are to be allocated to the trial, of which at least 176 patients will proceed to randomization. The primary endpoint is overall survival; main secondary endpoints are quality of life assessed by EORTC-QLQ-C30 questionnaire, progression free survival and surgical morbidity and mortality. Recruitment has already started; currently (Feb 2017) 22 patients have been enrolled. Discussion If the RENAISSANCE concept proves to be effective, this could potentially lead to a new standard of therapy. On the contrary, if the outcome is negative, patients with gastric or GEJ cancer and metastases will no longer be considered candidates for surgical intervention. Trial registration The article reports of a health care intervention on human participants and is registered on October 12, 2015 under ClinicalTrials.gov Identifier: NCT02578368 ; EudraCT: 2014–002665-30