Quality of life of people with epilepsy in Estonia

http://www.ester.ee/record=b1755471~S1*es

Pharmacokinetics of penicillin G in preterm and term neonates.

Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described for extremely preterm neonates but poorly for late-preterm and term neonates. Thus, evidence-based dosing recommendations are lacking. We described PK of penicillin G in neonates with gestational age (GA) ≥32 weeks and postnatal age 90% for MICs ≤2 mg/L with doses of 25,000 IU/kg/q12h. In neonates, regardless of GA, PK parameters of penicillin G are similar. The dose of 25,000 IU/kg/q12h is suggested for treatment of group B streptococcal EOS diagnosed within the first 72 hours of life

Automatic classification of Petri dish colony images

Práce se zabývá problematikou segmentace a klasifikace obrazů kolonií organismů kultivovaných na Petriho miskách. Je navržena segmentační metoda buněk a testovány různé klasifikační přístupy za účelem co nejvyšší spolehlivosti. Funkčnosti navržených metod jsou otestovány na obrazech poskytnutých firmou BioVendor Instruments a.s. Úspěšnost každé metody je hodnocena podle správnosti klasifikace obrazů do skupin. Optimalizované algoritmy jsou otestovány na databázi 250 obrazů.The thesis describe issue of segmentation and classification of Petri dishes colored images. There is proposed a segmentation method that extracts positions of cells from the image. Another techniques focues on classification to groups according to the parameters obtained from images. Reliability of each optimalized algorithm is tested on database containing 250 colored images received from company BioVendor Instruents a.s.

Assessing the Efficacy of an Online Support Program on the Chronic Disease Management of Adolescents with Type 1 Diabetes: A Pilot Randomized Controlled Trial

Background Guidelines surrounding the medical treatment of type 1 diabetes are clear. They are less clear for managing the psychosocial effects of the disease. Research has shown that educational group interventions can be effective at improving glycemic control and psychosocial outcomes in this patient population. Photovoice could serve as a novel diabetes group intervention for improving psychosocial outcomes in adolescents with type 1 diabetes. Methods We conducted a pilot randomized controlled trial on 17 patients with type 1 diabetes aged 13-17 years to compare the effects of an online support group using photography to one not using photography on diabetes-specific psychosocial outcomes. These outcomes were assessed using the Diabetes Distress Scale, Diabetes Empowerment Scale-Short Form, and Diabetes Management Questionnaire. Feasibility and acceptability were also examined. Results An online support group program using photography is feasible and accepted by adolescents with type 1 diabetes. No improvements in diabetes-related distress, diabetes empowerment, or diabetes treatment adherence were seen when compared to an online support group using no photography. However, exploratory data suggest that this group intervention reduces regimen-related distress among participants 4 weeks post-intervention. Conclusions To our knowledge, this is the first study to examine the effects of an online Photovoice-based group intervention on diabetes-specific outcomes. More research is needed to demonstrate its efficacy on glycemic control and other diabetes-specific outcome measures.Master of Public Healt

Removing methods of power line interference in ECG signals

Práce hodnotí účinnost číslicové lineární i nelineární filtrace na odstranění síťového rušení ze signálů EKG. Pro získání průměrných výsledků se pracuje s databází CSE, ve které je k dispozici 3750 čistých přirozených i umělých signálů. Po umělém poškození signálů brumem je účinnost filtrů hodnocena dle dosaženého průměrného výstupního poměru výkonu čistého signálu a šumu.The thesis is comparing efficiency of digital linear and nonlinear filtration used for removing power line interference from ECG signals. For testing was used database of CSE, containing 3750 ECG signals. After adding simulated power line interference into the clear ECG signal come comparing the efficiency of filters by average output signal to noise ratio.

O SURGIMENTO E A IMPORTÂNCIA DA GEOGRAFIA DO TRABALHO

Esse texto preocupa-se com o tratamento teórico dado ao tema do trabalho na geografia no intuito de apontar sua relevância para compreensão do atual mundo do trabalho. Dentro do quadro da geografia, essa temática por muito tempo apareceu como um assunto periférico, diluído nas análises da geografia econômica. Constituído no plano formal como um objeto a ser descrito, não havia destaque nessas análises os conflitos entre capital e trabalho. No decorrer dos anos de 1970 e 1980, a geografia passa por intensas transformações provenientes da influência do marxismo que levaram a uma crescente discussão de problemáticas sociais no âmbito do espaço social. Com isso, a temática do trabalho começa a ganhar destaque, inicialmente diluída em análises sobre os impacto do desenvolvimento desigual do capital. Posteriormente, o foco das análises dirige-se a temas específicos acerca da organização dos trabalhadores, suas formas de luta e condições de trabalho.  Palavras chaves: Geografia; trabalho; espaço; reestruturação produtiva

Pengaruh Pupuk Kotoran Ayam Dan Jarak Tanam Terhadap Pertumbuhan dan Hasil Tanaman Mentimun Jepang (Cucumis stivus L.) Varietas Roberto

Mentimun jepang merupakan salah satu jenis sayuran buah yang belum banyak memenuhi kebutuhan pasar sehingga mentimun jepang menjadi salah satu peluang untuk dibudidayakan. Pemberian pupuk kotoran ayam dan pengaturan jarak tanam yang tepat merupakan salah satu upaya untuk meningkatkan produksi tanaman mentimun jepang. Penelitian ini bertujuan untuk mengetahui Pengaruh Pupuk Kotoran Ayam Dan Jarak Tanam Terhadap Pertumbuhan dan Hasil Tanaman Mentimun Jepang (Cucumis sativus L.) Var. Roberto. Telah dilakukan di kebun percobaan, Ciparanje Jatinangor Universitas Padjadjaran (Unpad) dari bulan Juli sampai dengan bulan Agustus 2015, menggunakan Rancangan Acak Kelompok (RAK) pola faktorial dengan tiga kali ulangan yang terdiri atas dua faktor. Faktor pertama pupuk kotoran ayam yang terdiri atas 4 taraf: (k0) tanpa pupuk kotoran ayam (k1) pupuk kotoran ayam 15 t ha-1 (k2) pupuk kotoran ayam 25 t ha-1. (k3) pupuk kotoran ayam 35 t ha-1. Faktor kedua jarak tanam yang terdiri atas 3 taraf: (j1) jarak tanam 60 x 20 cm. (j2) jarak tanam 60 x 30 cm. (j3) jarak tanam 60 x 40 cm. Dengan parameter pengamatan meliputi tinggi tanaman, luas daun, bobot segar brangkasan per tanaman, bobot kering brangkasan per tanaman, Nisbah Pupus Akar. Dan bobot segar buah per tanaman. Hasil penelitian menunjukan bahwa terjadi interaksi pada bobot buah per tanaman. Dosis pupuk kotoran ayam 35 t ha-1 (k3) dan jarak tanam 60 x 40 cm (j3) memberikan hasil paling baik dalam meningkatkan pertumbuhan dan hasil tanaman mentimun jepang

Effect of photoperiod on sexual development, growth and production of quail (coturnix coturnix japonica)

The aim of the study was to determine the effect of photoperiod on production of quail in South Africa. Day old chicks were randomly divided into two groups. One group (n=74) received continuous light (LL) while the other group (n=77) received 13 h of light (LD) per day. Traits measured were sexual characteristics (age at sexual maturity and testis weight, egg production and egg weight) and growth (body weight) development in males and females respectively. Significant differences in growth existed between sexes; females were 171.44±17.15 and 182.91±17.75 g compared to the 151.77±13.20 and 155.00±16.86 g for males in both LL and LD groups respectively. Both males and females in the LL group initially outperformed the LD group in growth rate but, by day 72 the LD group had compensated and were 4.6% heavier than the LL group. A similar trend was observed for sexual maturity between the LL and LD groups. However, photoperiod did significantly influence initial egg production in favour of the LL group. The LL group had 80% of the females in production by day 44 compared to the 60% of the LD group. The initial egg weight of the LL group was 14 % higher than those of the LD group. Quail subjected to continuous light attained earlier sexual maturity and production with lower final weight compared to quail subjected to an intermediate photoperiod. The application of a longer photoperiod would therefore favour an egg production system

Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate

Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method calibration range established during validation and no data are available to support the reliability of these values. However, ignoring BLQ data can contribute to bias and imprecision in model-based pharmacokinetic analyses. From this perspective, routine use of BLQ data would be advantageous. We would like to initiate an interdisciplinary debate on this important topic by summarizing the current concepts and use of BLQ data by regulators, pharmacometricians and bioanalysts. Through introducing the limit of detection and evaluating its variability, BLQ data could be released and utilized appropriately for pharmacokinetic research