Evaluation and demonstration of the use of cryogenic propellants /oxygen/hydrogen/ for reaction control systems. Volume 2 - Experimental evaluations and demonstration Final report

Evaluation and demonstration of cryogenic propellant /oxygen-hydrogen/ use for spacecraft reaction control system

Demonstration of a pulsing liquid hydrogen/liquid oxygen thruster

Successful operation of a pulsing liquid hydrogen/liquid oxygen attitude control propulsion system thruster (1250 lb sub f) at cryogenic inlet conditions while maintaining high specific impulse and low impulse bit capability was demonstrated. Significant technical advances and departures from conventional injector design practices were necessary in order to achieve an operable thruster. These advancements were achieved through extensive analyses of heat transfer and injector manifold priming that established the baseline feasibility for an actual hardware design. The primary subject of this paper is the result of experimental evaluation of the 45 R hydrogen inlet temperature injector concept. The test matrix consisted of 66 hot firing tests in a heat sink thrust chamber

Stability diagram of colliding beams

The effect of the beam-beam interactions on the stability of impedance mode is discussed. The detuning is evaluated by the means of single particle tracking in arbitrarily complex collision configurations, including lattice non-linearities, and used to numerically evaluate the dispersion integral. This approach also allows the effect of non-Gaussian distributions to be considered. Distributions modified by the action of external noise are discussed.Comment: 5 pages, contribution to the ICFA Mini-Workshop on Beam-Beam Effects in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 Mar 201

Temporal Variability of Urinary Phthalate Metabolite Levels in Men of Reproductive Age

Phthalates are a family of multifunctional chemicals widely used in personal care and other consumer products. The ubiquitous use of phthalates results in human exposure through multiple sources and routes, including dietary ingestion, dermal absorption, inhalation, and parenteral exposure from medical devices containing phthalates. We explored the temporal variability over 3 months in urinary phthalate metabolite levels among 11 men who collected up to nine urine samples each during this time period. Eight phthalate metabolites were measured by solid-phase extraction–high-performance liquid chromatography–tandem mass spectrometry. Statistical analyses were performed to determine the between- and within-subject variance apportionment, and the sensitivity and specificity of a single urine sample to classify a subject’s 3-month average exposure. Five of the eight phthalates were frequently detected. Monoethyl phthalate (MEP) was detected in 100% of samples; monobutyl phthalate, monobenzyl phthalate, mono-2-ethylhexyl phthalate (MEHP), and monomethyl phthalate were detected in > 90% of samples. Although we found both substantial day-to-day and month-to-month variability in each individual’s urinary phthalate metabolite levels, a single urine sample was moderately predictive of each subject’s exposure over 3 months. The sensitivities ranged from 0.56 to 0.74. Both the degree of between- and within-subject variance and the predictive ability of a single urine sample differed among phthalate metabolites. In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements

The recent discovery that the activation domains of transcriptional activators (e.g., GAL4) from a number of species are interchangeable has led to the concept of a general mechanism for activation of RNA polymerase II genes. We have examined the different activities of the SV40 octamer motif ATGCAAAG in B cells and in HeLa cells in the context of either the beta-globin promoter, a TATA-box-containing mRNA promoter, or the U2 snRNA promoter, which contains a snRNA-specific proximal element. In the context of the beta-globin promoter, the octamer motif is a B-cell-specific enhancer element, whereas it is a ubiquitous enhancer element for the U2 snRNA promoter. The U2 promoter is unique in that it is not activated by enhancer elements that activate the beta-globin promoter, and a hybrid U2 promoter containing the upstream activating sequence UASG is not stimulated by a yeast GAL4 trans-activator. Together, these observations suggest that in the context of the U2 promoter, the octamer motif defines a new class of RNA polymerase II enhancer elements, which bind transcription factors that trans-activate gene expression by a different mechanism than the general mechanism mentioned above. These results are discussed in light of the possibility that the ubiquitous octamer binding protein Oct-1 and the B-cell-specific octamer binding protein Oct-2 are involved in the activation of the U2 and beta-globin promoters, respectively

Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation

The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been completely characterized. Ca(2+) can bind to calmodulin and this complex regulates the activity of multiple enzymes, including Ca(2+)/calmodulin-dependent protein kinases (CaM kinases). Results from this study confirmed that the presence of Ca(2+) in the incubation medium is essential for maintaining human sperm motility. The involvement of CaM kinases in Ca(2+) regulation of human sperm motility was evaluated using specific inhibitors (KN62 and KN93) or their inactive analogues (KN04 and KN92 respectively). Sperm incubation in the presence of KN62 or KN93 led to a progressive decrease in the percentage of motile cells; in particular, incubation with KN62 also reduced sperm motility parameters. These inhibitors did not alter sperm viability, protein tyrosine phosphorylation or the follicular fluid-induced acrosome reaction; however, KN62 decreased the total amount of ATP in human sperm. Immunological studies showed that Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is present and localizes to the human sperm flagellum. Moreover, CaMKIV activity increases during capacitation and is inhibited in the presence of KN62. This report is the first to demonstrate the presence of CaMKIV in mammalian sperm and suggests the involvement of this kinase in the regulation of human sperm motility.Fil: Marin Briggiler, Clara Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Jha, Kula N.. University of Virginia; Estados UnidosFil: Chertihin, Olga. University of Virginia; Estados UnidosFil: Buffone, Mariano Gabriel. Laboratorio de Estudios en Reproducción; ArgentinaFil: Herr, John C,. University of Virginia; Estados UnidosFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Visconti, Pablo E.. University of Massachussets; Estados Unido

A para-differential renormalization technique for nonlinear dispersive equations

For \alpha \in (1,2) we prove that the initial-value problem \partial_t u+D^\alpha\partial_x u+\partial_x(u^2/2)=0 on \mathbb{R}_x\times\mathbb{R}_t; u(0)=\phi, is globally well-posed in the space of real-valued L^2-functions. We use a frequency dependent renormalization method to control the strong low-high frequency interactions.Comment: 42 pages, no figure

Characteristics of the channels and blood parameters of chickens complemented with chromium and their productive acting

P?ginas 15-19Recurso Electr?nicoEl presente trabajo evalu? el efecto del cromo en dietas para pollo de engorde con diferentes niveles de inclusi?n. Se evalu? : peso inicial, peso final, ganancia de peso, conversi?n, consumo, rendimiento en canal, peso de alas, pechuga, pernil, colesterol, glicemia y HDL. Se emplearon 96 aves distribuidas en 4 tratamientos con 4 repeticiones y 6 aves en cada una, alimentadas con cromo a partir del d?a noveno de vida hasta el d?a 35. Los tratamientos 1, 2, 3, y 4 conten?an cromo en 0ppm, 0,5 ppm, 1 ppm, y 1,5 ppm en la dieta respectivamente. No se encontraron diferencias significativas (p0,05) en el consumo de alimento. Pese a lo anterior los mejores resultados obtenidos se presentaron en los tratamientos 2. Peso final (1983.3 g vs 2032,3 g), ganancia de peso (1811,9 g vs 1859,9 g ), conversi?n (1,666 vs 1,670). Con respecto al consumo el tratamiento control presento consumo m?s bajo (3305 g vs 3395 g), y rendimiento en canal el tratamiento control presento mejor rendimiento con respecto a los dem?s tratamientos (71,8 % vs 71,3 %). Con respecto a los cortes los resultados favorecen a los tratamientos con cromo, alas (172,9 g vs 181,5 g), pechugas (536,3 g vs 545,1 g), perniles (699,1 g vs 708,6 g). Se determin? que el tratamiento 2 presenta los mejores resultados econ?micos.ABSTRACT. This project aims to evaluate the effect of chromium in breeding chicken diets with different inclusion levels. The items evaluated were: initial weight, final weight, increase in weight, conversion, consumptions, carcass development, wings, breasts, and legs weight, cholesterol, blood sugar, and HDL. A sample of 96 birds was used distributed in 4 treatments with 4 repetitions and 6 birds each, fed with chromium since the 9th day of life until day 35. Treatments 1, 2, 3 and 4 had chromium concentrations of 0 ppm, 0,5 ppm, 1 ppm, and 1,5 ppm in their diet respectively. No significant differences were found (p0,05) was food consumption. Nevertheless, the best results were found in birds subjected to treatment 2: Final weight (1983,3 g vs. 2032,3 g), increase in weight (1811,9 g vs. 1859,9 g), and conversion (1.666 vs. 1.670). Regarding consumption, the control treatment presented the lowest rate (3305 g vs. 3395 g); and regarding yield in channel, the control treatment presented better outputs than the others (71,8 % vs 71,3 %). Examining other criteria, outputs favor chromium treatments: wings (172,9 g vs. 181,5 g), breasts (536,3 g vs. 545,1 g), and legs (669,1 g vs. 708,6 g). Therefore, it was determined that treatment 2 brings better economic results

Multi Sector Planning Tools for Trajectory-Based Operations

This paper discusses a suite of multi sector planning tools for trajectory-based operations that were developed and evaluated in the Airspace Operations Laboratory (AOL) at the NASA Ames Research Center. The toolset included tools for traffic load and complexity assessment as well as trajectory planning and coordination. The situation assessment tools included an integrated suite of interactive traffic displays, load tables, load graphs, and dynamic aircraft filters. The planning toolset allowed for single and multi aircraft trajectory planning and data communication-based coordination of trajectories between operators. Also newly introduced was a real-time computation of sector complexity into the toolset that operators could use in lieu of aircraft count to better estimate and manage sector workload, especially in situations with convective weather. The tools were used during a joint NASA/FAA multi sector planner simulation in the AOL in 2009 that had multiple objectives with the assessment of the effectiveness of the tools being one of them. Current air traffic control operators who were experienced as area supervisors and traffic management coordinators used the tools throughout the simulation and provided their usefulness and usability ratings in post simulation questionnaires. This paper presents these subjective assessments as well as the actual usage data that was collected during the simulation. The toolset was rated very useful and usable overall. Many elements received high scores by the operators and were used frequently and successfully. Other functions were not used at all, but various requests for new functions and capabilities were received that could be added to the toolset