The unidirectional relationship of nightmares on self-harmful thoughts and behaviors

Understanding the direction of the predictive relationship between nightmares and suicidal behaviors is important to model its underlying mechanisms. We examine the direction of this relationship and the mediating role of negative affect. A fixed interval diary study obtained pre-sleep and post-sleep measures of affect, nightmares, and self-harmful thoughts and behaviors (SHTBs) from 72 university students (88.9% female). The results show predictive utility of nightmares on SHTBs - indicating a fourfold increased risk of SHTBs. Additionally, results support the suggestion of a unidirectional predictive influence (of nightmares on likelihood of SHTBs but not vice versa). Moreover, postsleep negative affect partially mediated the relationship between nightmares and postsleep SHTBs. This empirically validates assumptions of directionality for future models

The behavioral effects of frequent nightmares on objective stress tolerance.

Frequent nightmares have been linked to daily distress using self-report measures. The present study investigated the impact of frequent nightmares on a stressful cognitive test requiring participants to perform additions of 2 previously displayed single digit numbers from a number series, where display latency between digits becomes increasingly short—the Paced Visual Serial Addition Task-Computerized (PVSAT-C). Participants experiencing frequent nightmares (n = 43) and controls (n = 42) were compared on PVSAT-C performance. A significant main effect of nightmare frequency was observed with participants in the frequent nightmare group enduring the task for a shorter duration than controls (a behavioral measure of stress tolerance). Results suggest that individuals experiencing frequent nightmares have a reduced tolerance for stressors, leading to increased daily vulnerability to stressful stimuli. This study confirms previous findings linking nightmares and daily distress and extends the literature by providing objective evidence for the link between nightmares and reduced stress tolerance through behavioral testing. These findings highlight nightmares as a salient target for clinical intervention

Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition

Attention-Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, comorbidity and inhibitory control deficits have been proposed for both. Whilst such deficits have been studied widely within clinical populations, findings are mixed—partly due to comorbidity and/or medication effects—and studies have rarely distinguished between subtypes of the disorders. Studies in the general population are sparse. Using a continuity approach, the present study examined (i) the relationships between inattentive and hyperactive/impulsive aspects of ADHD and TS-like behaviors in the general population, and (ii) their unique associations with automatic and executive inhibitory control, as well as (iii) yawning (a proposed behavioural model of TS).One hundred and thirty-eight participants completed self-report measures for ADHD and TS-like behaviors as well as yawning, and a conditioned inhibition task to assess automatic inhibition. A sub-sample of fifty-four participants completed three executive inhibition tasks. An exploratory factor analysis of the TS behaviour checklist supported a distinction between phonic and motorlike pure TS behaviors. Whilst hyperactive/impulsive aspects of ADHD were associated with increased pure and compulsive TS-like behaviors, in attention in isolation was related to reduced obsessive-compulsive TS-like behaviors. TS-like behaviors were associated with yawning during situations of inactivity, and specifically motor TS was related to yawning during stress. Phonic TS and inattention aspects of ADHD were associated with yawning during concentration/activity. Whilst executive interference control deficits were linked to hyperactive/impulsive ADHD-like behaviors, this was not the case for inattentive ADHD or TS-like behaviors, which instead related to increased performance on some measures. No associations were observed for automatic conditioned inhibition

An evaluation of the relationship between Gray’s revised RST and Eysenck’s PEN: distinguishing BIS and FFFS in Carver and White’s BIS/BAS scales

Recent revisions of Gray's Reinforcement Sensitivity Theory (RST) have important implications for self-report measures of approach and avoidance behaviours and how Gray's model relates to other personality models. In this paper, we examine the revised RST by comparing Carver and White's (1994) original one-factor solution of the BIS scale with two alternative two-factor solutions separating BIS-Anxiety and FFFS-Fear. We also examine the relationships between Eysenck's PEN and revised RST factors. Two hundred and twelve participants completed Carver and White's BIS/BAS scales and Eysenck's Personality Questionnaire-Revised. Confirmatory factor analyses of the original BIS scale showed that the hypothesized two-factor model of BIS-Anxiety and FFFS-Fear was the best fit to these data. Associations between the revised RST and Eysenck's PEN were examined using path analysis. In line with theoretical predictions, Psychoticism was related to revised BIS-Anxiety and BAS, Neuroticism to revised BIS-Anxiety and FFFS- Fear, and Extraversion to BAS and FFFS-Fear. Distinctions between BAS subscales and their associations to BIS, N and P were made in terms of past, present and future focus. Possible explanations for mixed findings in the literature and implications for future research are discussed

Neurophysiological correlates of excitement in men with recent-onset psychosis

Objective: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. Subjects and methods: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task. Results: Multiple linear regression analysis showed that 58% of the variance in the excitement symptom cluster was explained by a positive association with frontal midline N200 amplitude and an inverse association with right frontal N200 amplitude. The latter was not apparent in the initial correlation, suggesting suppression by the midline activity. These associations were not explained by drug use, medication or negative symptoms. However, the correlation between excitement and midline N200 was stronger in drug users, and that between right frontal N200 and excitement was stronger in nonusers. Conclusion: Findings support the independent contributions to excitement of mechanisms reflected in midline and right frontal N200 amplitude respectively during the early stages of psychosis

Enabling Personalized Composition and Adaptive Provisioning of Web Services

The proliferation of interconnected computing devices is fostering the emergence of environments where Web services made available to mobile users are a commodity. Unfortunately, inherent limitations of mobile devices still hinder the seamless access to Web services, and their use in supporting complex user activities. In this paper, we describe the design and implementation of a distributed, adaptive, and context-aware framework for personalized service composition and provisioning adapted to mobile users. Users specify their preferences by annotating existing process templates, leading to personalized service-based processes. To cater for the possibility of low bandwidth communication channels and frequent disconnections, an execution model is proposed whereby the responsibility of orchestrating personalized processes is spread across the participating services and user agents. In addition, the execution model is adaptive in the sense that the runtime environment is able to detect exceptions and react to them according to a set of rules

Risk as reward: Reinforcement sensitivity theory and psychopathic personality perspectives on everyday risk-taking

This study updates and synthesises research on the extent to which impulsive and antisocial disposition predicts everyday pro- and antisocial risk-taking behaviour. We use the Reinforcement Sensitivity Theory (RST) of personality to measure approach, avoidance, and inhibition dispositions, as well as measures of Callous-Unemotional and psychopathic personalities. In an international sample of 454 respondents, results showed that RST, psychopathic personality, and callous-unemotional measures accounted for different aspects of risk-taking behaviour. Specifically, traits associated with ‘fearlessness’ related more to ‘prosocial’ (recreational and social) risk-taking, whilst traits associated with ‘impulsivity’ related more to ‘antisocial’ (ethical and health) risk-taking. Further, we demonstrate that psychopathic personality may be demonstrated by combining the RST and callous-unemotional traits (high impulsivity, callousness, and low fear). Overall this study showed how impulsive, fearless and antisocial traits can be used in combination to identify pro- and anti-social risk-taking behaviours; suggestions for future research are indicated

Multilocus Sequence Typing Scheme versus Pulsed-Field Gel Electrophoresis for Typing Mycobacterium abscessus Isolates

Outbreaks of infections by rapidly growing mycobacteria following invasive procedures, such as ophthalmological, laparoscopic, arthroscopic, plastic, and cardiac surgeries, mesotherapy, and vaccination, have been detected in Brazil since 1998. Members of the Mycobacterium chelonae-Mycobacterium abscessus group have caused most of these outbreaks. As part of an epidemiological investigation, the isolates were typed by pulsed-field gel electrophoresis (PFGE). in this project, we performed a large-scale comparison of PFGE profiles with the results of a recently developed multilocus sequence typing (MLST) scheme for M. abscessus. Ninety-three isolates were analyzed, with 40 M. abscessus subsp. abscessus isolates, 47 M. abscessus subsp. bolletii isolates, and six isolates with no assigned subspecies. Forty-five isolates were obtained during five outbreaks, and 48 were sporadic isolates that were not associated with outbreaks. for MLST, seven housekeeping genes (argH, cya, glpK, gnd, murC, pta, and purH) were sequenced, and each isolate was assigned a sequence type (ST) from the combination of obtained alleles. the PFGE patterns of DraI-digested DNA were compared with the MLST results. All isolates were analyzable by both methods. Isolates from monoclonal outbreaks showed unique STs and indistinguishable or very similar PFGE patterns. Thirty-three STs and 49 unique PFGE patterns were identified among the 93 isolates. the Simpson's index of diversity values for MLST and PFGE were 0.69 and 0.93, respectively, for M. abscessus subsp. abscessus and 0.96 and 0.97, respectively, for M. abscessus subsp. bolletii. in conclusion, the MLST scheme showed 100% typeability and grouped monoclonal outbreak isolates in agreement with PFGE, but it was less discriminative than PFGE for M. abscessus.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilAdolfo Lutz Inst, Nucleo TB & Micobacterioses, São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Oftalmol, São Paulo, BrazilUniv Fed Espirito Santo, Nucleo Doencas Infecciosas, Vitoria, ES, BrazilInst Evandro Chagas, Belem, Para, BrazilFiocruz MS, Escola Nacl Saude Publ, Ctr Referencia Prof Helio Fraga, BR-21045900 Rio de Janeiro, BrazilHop Univ Paris Ile de France Ouest, Hop Ambroise Pare, AP HP, Microbiol Lab, Boulogne, FranceUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Oftalmol, São Paulo, BrazilFAPESP: 2011/18326-4FAPESP: 2012/18038-1FAPESP: 2012/07335-5FAPESP: 2013/16018-6Web of Scienc