Rate constants and Arrhenius parameters for the reactions of OH radicals and Cl atoms with CF3CH2OCHF2, CF3CHClOCHF2 and CF3CH2OCClF2, using the discharge-flow/resonance fluorescence method

Rate constants have been determined for the reactions of OH radicals and Cl atoms with the three partially halogenated methyl-ethyl ethers, CF$_3$CH$_2$OCHF$_2$, CF$_3$CHClOCHF$_2$ and CF$_3$CH$_2$OCClF$_2$, using discharge-flow techniques to generate the OH radicals and the Cl atoms and resonance fluorescence to observe changes in their relative concentrations in the presence of added ether. For each combination of radical and ether, experiments were carried out at three temperatures between 292 and 410 K, yielding the following Arrhenius expressions for the rate constants within this range of temperature: OH + CF$_3$CH$_2$OCHF$_2$: $k$ = (2.0$\pm$0.8) $\times$ 10$^{-11}$ exp( – 2110 $\pm$ 150 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ OH + CF$_3$CHClOCHF$_2$: $k$ = (4.5 $\pm$ 1.3) $\times$ 10$^{-13}$ exp( – 940 $\pm$ 100 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ OH + CF$_3$CH$_2$OCClF$_2$: $k$ = (1.6 $\pm$ 0.6) $\times$ 10$^{-12}$ exp( – 1100 $\pm$ 125 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ Cl + CF$_3$CH$_2$OCHF$_2$: $k$ = (6.1 $\pm$ 1.4) $\times$ 10$^{-12}$ exp( – 1830 $\pm$ 90 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ Cl + CF$_3$CHClOCHF$_2$: $k$ = (7.8 $\pm$ 2.6) $\times$ 10$^{-11}$ exp( – 2980 $\pm$ 130 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ Cl + CF$_3$CH$_2$OCClF$_2$: $k$ = (2.2 $\pm$ 0.2) $\times$ 10$^{-11}$ exp( – 2700 $\pm$ 40 K / T) cm$^3$ molecule$^{-1}$ s$^{-1}$ The results are compared with those obtained previously for the same and related reactions of OH radicals and Cl atoms, and the atmospheric implications of the results are considered briefly

Vital Statistics Ireland: findings from the All-Ireland Gay Men’s Sex Survey 2000

Duration: March 2000 - September 2010 Sigma Research has been working with Ireland's Gay Health Network (GHN) since 2000. GHN is an umbrella organisation working towards gay men's health and HIV prevention. GHN instigated a community-based, self-completion survey to take place across The Republic of Ireland and Northern Ireland during the summer of 2000 and commissioned Sigma Research to work with them. This large-scale community research project was the third such survey among gay men in Ireland, and built on previous findings. After the development and piloting of the survey, recruitment commenced at Dublin Pride in June 2000 and continued throughout the summer at similar events in Belfast, Derry, Galway, Limerick and Waterford. Recruitment in bars and clubs took place in Dublin and Cork, and social groups in more rural area were sent copies of the questionnaire and a request to distribute them to their members. 1,290 questionnaires were returned by gay men (81%), bisexual men (11%) and other homosexually active men living in Ireland. 19% of all respondents lived in Northern Ireland. A full survey report, including implications for HIV prevention planning is available to download. Since 2003 Gay Health Network members - particularly The Gay Men's Health Service (Health Services Executive) and the Rainbow Project, Northern Ireland - have collaborated with our online UK version of the Gay Men’s Sex Survey (Vital Statistics) by promoting it to men in Ireland via community websites and postcards distributed on the gay scene. Real Lives, a summary report covering the main GMSS 2003 and 2004 data for men resident on the island of Ireland, was published in June 2006 and is available to download. It was published with The Gay Men's Health Service, Health Services Executive and the Rainbow Project. Real Lives II, a summary report covering the main GMSS 2005 and 2006 data for men resident on the island of Ireland, was published in June 2009 and is available to download. It was published with The Gay Men's Health Service, Health Services Executive and the Rainbow Rpoject. A summary report for Irish-resident men taking part in GMSS 2007 and 2008 will be published in June 2010

HIV, sexual risk and ethnicity among gay and bisexual men in England: survey evidence for persisting health inequalities.

To examine ethnic group differences in HIV testing and sexual behaviours among a large sample of gay and bisexual men (GBM), 13 years after similar observations were made, assess national HIV prevention responses and inform planning priorities. Cross-sectional convenience self-completion online survey in summer 2014, designed and recruited in collaboration with community-based health promoters and gay internet services; comparison with earlier findings reporting on similarly designed survey in 2001. We recruited 15 388 GBM living in England who self-reported as follows: 18.5% from ethnic minorities; 9.0% tested HIV positive (cf. 17.0% and 5.4% in 2001). Compared with the white British, Asian men were no longer less likely to report diagnosed HIV but had an equal probability of doing so (2001 OR=0.32, 95% CI 0.13 to 0.79; 2014 OR=1.04, 95% CI 0.71 to 1.54); black men remained significantly more likely to report diagnosed HIV (2001 OR=2.06, 95% CI 1.56 to 3.29; 2014 OR=1.62, 95% CI 1.10 to 2.36) as did men in the other white group (2001 OR=1.54, 95% CI 1.23 to 1.93; 2014 OR=1.31, 95% CI 1.10 to 1.55). Overall annual incidence of reported HIV diagnoses in 2014 was 1.1%. Black men were significantly more likely to report diagnosis with HIV in the last 12 months than the white British (adjusted odds ratios (AOR) 2.57, 95% CI 1.22 to 5.39). No minority ethnic group was more or less likely to report condom unprotected anal intercourse (CUAI) in the last year but men in the Asian, black and all others groups were more likely than the white British to report CUAI with more than one non-steady partners. Among GBM in England, HIV prevalence continues to be higher among black men and other white men compared with the white British. The protective effect of being from an Asian background appears no longer to pertain. Sexual risk behaviours may account for some of these differences

Temporal variability of the telluric sodium layer

The temporal variability of the telluric sodium layer is investigated by analyzing 28 nights of data obtained with the Colorado State University LIDAR experiment. The mean height power spectrum of the sodium layer was found to be well fit by a power law over the observed range of frequencies, 10 microhertz to 4 millhertz. The best fitting power law was found to be 10^\beta \nu^\alpha, with \alpha = -1.79 +/- 0.02 and \beta = 1.12 +/- 0.40. Applications to wavefront sensing require knowledge of the behavior of the sodium layer at kHz frequencies. Direct measurements at these frequencies do not exist. Extrapolation from low-frequency behavior to high frequencies suggests that this variability may be a significant source of error for laser-guide-star adaptive optics on large-aperture telescopes.Comment: 3 pages, 3 figures, accepted for publication in Optics Letter

USP45 and Spindly are part of the same complex implicated in cell migration

Abstract Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by using mass spectrometry we have identified Spindly as a new target of USP45. Our data show that Spindly and USP45 are part of the same complex and that their interaction specifically depends on the catalytic activity of USP45. In addition, we describe the type of ubiquitin chains associated with the complex that can be cleaved by USP45, with a preferential activity on K48 ubiquitin chain type and potentially K6. Here, we also show that Spindly is mono-ubiquitylated and this can be specifically removed by USP45 in its active form but not by the catalytic inactive form. Lastly, we identified a new role for USP45 in cell migration, similar to that which was recently described for Spindly

Are you a researcher as well as a medical illustrator?

When we list the areas of practice for medical illustrators we always include research, but how involved in research are we? The aim of this activity is to encourage your professional development not just as a medical illustrator but your involvement with research whether that is undertaking your own research, undertaking evidence based practice (1) , working as part of a research team, advising researchers on the value of medical illustration or supporting a student undertaking a research project for their degree or post-graduate qualification