Tea in the Historical Context of East Asia: Cultural Interactions across Borders

(Translated: Jenine Heaton) Session statement 4: Tea viewed from the comparative culture and cultural interactio

Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila

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The determination of uric acid using modified Patel's method

N 13-b method for determination of uric acid by AutoAnalyzer- I was proposed from Technicon Corporation, but the sensitivity of this method was insufficient. According to the modification by Patel, good sensitivity was obtained for determining of uric acid, but insufficient separation between peaks was accompanied. To get good separation, Patel's method was reexamined by the authors, and the results were as follows. Sufficient separation was obtained by modifing the flow diagram of Patel's method. The mean recovery rates of uric acid added to serum and urine were 103.6% and 102.5%, and coefficients of variation were 1.27% and 1.05% respectively. The correlation between this modified Patel's method and the U.A. test Wako method was recognized (serum : n=95, r=0.97, urine : n=35, r =0.99). According to our modified method, uric acid concentration in serum of 68 subjects, were 5.8±0.9mg/100ml in 29 males and 4.4±0.8mg/100ml in 39 females

Atypical lymphoplasmacytic and immunoblastic proliferation: A Systematic Review

Atypical lymphoplasmacytic and immunoblastic proliferation (ALPIBP) was first reported in 1984 as characteristic histological findings in lymph nodes associated with autoimmune diseases, but it has not been clearly defined to date. To summarize the histological characteristics and clinical diagnoses associated with ALPIBP, we searched MEDLINE and EMBASE for all peer-reviewed articles using keywords including “atypical lymphoplasmacytic and immunoblastic lymphadenopathy” from their inception to December 27, 2023. We also summarized the courses of three cases with a pathological diagnosis of ALPIBP. Nine articles with 52 cases were included. Among the total of 55 cases, including the three from our institution, the median age of the cases was 63.5 years with a female predominance (69.5%). Lymphadenopathy was generalized in 65.6% and regional in 34.4% of cases. RA (24.4%), SLE (24.4%), and autoimmune hemolytic anemia (20.0%), were common clinical diagnoses. A combination of cytotoxic chemotherapy was used in 15.6% of cases due to the suspicion of malignancy. Nodal T-follicular helper cell lymphoma, angioimmunoblastic type, methotrexate-associated lymphoproliferative disorders, and IgG4-related diseases were listed as important diseases that need to be pathologically differentiated from ALPIBP. This review summarizes the current understanding of the characteristics of ALPIBP. Given that underrecognition of ALPIBP could lead to overdiagnosis of hematological malignancy and unnecessary treatment, increased awareness of the condition in pathologists and clinicians is crucial

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.

横紋筋肉腫におけるゲノム・エピゲノム異常の全体図を解明 -横紋筋肉腫を4群に分類-. 京都大学プレスリリース. 2015-07-03.Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar histology with frequent PAX3/7 fusions and alterations in cell cycle regulators. In contrast, mostly showing embryonal histology, both E1 and E2 subtypes are characterized by high frequency of CN alterations and/or allelic imbalances, FGFR4/RAS/AKT pathway mutations and PTEN mutations/methylation and in E2, also by p53 inactivation. Despite the better prognosis of embryonal RMS, patients in the E2 are likely to have a poor prognosis. Our results highlight the close relationships of the methylation status and gene mutations with the biological behaviour in RMS

The Life and Language of Taisho Era Girls: The Diary of a Child (Yoshie Doi), Okawa, Kumakogen, Kamiukena, Ehime Prefecture

愛媛県上浮穴郡久万高原町大川の土居家に伝わる史料の中に、大正期の少女の日記がある。今から100年ほど前、土居家第28 代当主土居貫太郎の長女、土居芳枝が大正10 ～ 11 年（1921 ～ 1922 年）尋常小学校3 ～ 4 年生の時に書かれた日記である。この資料には、日々の生活が方言交じりで記録され、当時の子どもの生活やことばが分かる資料となっている。本稿は、この日記を翻刻し、近代の子どもの家での生活やことばを研究するための基礎資料として紹介する。Among the historical materials passed down through generations of the Doi family of Okawa, Kuma-Kogen-cho,Kamiukena-gun, Ehime Prefecture, was the diary of the Taisho era schoolgirl Yoshie Doi, eldest daughter of the 28thgeneration Doi, Kantaro Doi. Written between 1921 and 1922, when Yoshie was in grades 3 and 4 of elementaryschool, the diary describes events in her daily life, recorded in the local dialect. In this paper, the diary is reprinted, asit is a valuable chronicle that helps readers today to understand the child's Taisho era homelife and language use.departmental bulletin pape