Characteristics of Fatal Cases of Pandemic Influenza A (H1N1) from September 2009 to January 2010 in Saurashtra Region, India

Background: India reported first case of 2009 pandemic influenza A (H1N1) virus infection in May, 2009 and Saurashtra region in August, 2009. We describe the characteristics of fatal cases of 2009 influenza A (H1N1) infection reported in Saurashtra region. Methods: From September, 2009 to January, 2010, we observed 71 fatal cases that were infected with 2009 influenza A (H1N1) virus and admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features were observed and documented. Results: Median age of the deceased (71) was 29 years, and 57.7% were females. Median time observed was 5 days from onset of illness to diagnosis of influenza A (H1N1), and 57.7% were referred from general practitioner (OR=0.42, CI=0.24-0.74). Median hospital stay reported was 3 days. All admitted patients received oseltamivir, but only 16.9% received it within 2 days of onset of illness. The most common symptoms were cough (97.2%), fever (93%), sore throat and shortness of breath. Co-morbid conditions were present in almost half of the patients who ultimately died, the most common of which was pregnancy (OR=0.15, CI=0.04-0.52). Radiological pneumonia was reported in 98% patients. Conclusion: Residing in urban area, delayed referral from general practitioner, presence of co-existing condition, especially pregnancy was responsible for mortality among influenza A (H1N1) infected positive

A retrospective study of 72 cases diagnosed with idiopathic trigeminal neuralgia in indian populace

Context: Trigeminal neuralgia is as a chronic, debilitating condition, which can have a major impact on quality of life. There are few reports of trigeminal neuralgia in oriental populations. Objectives: To evaluate the retrospective data of the patients diagnosed with idiopathic trigeminal neuralgia and to understanding the disorder in the Indian populace. Methods: The retrospective data of 72 patients with typical idiopathic trigeminal neuralgia regarding age of onset, gender, site of involvement, clinical presentations and treatment received during three years of the follow up was collected and analyzed. Results: In the present retrospective study, the mean age was 54.9 years; female to male ratio was 2.13:1; rural to urban ratio 1.76:1 with 62.5% suffered trigeminal neuralgic pain on the right side. Carbamazepine was found to be highly effective in 60.8% of the cases on long-term basis with maintenance doses. Other treatment modalities were employed in more refractory cases including add-on of gabapentin, which relieved the symptoms for an additional duration of 13±3months. The neurolytic alcohol bloc was given in 30% of patients who stopped responding to com - bination of carbamazepine and gabapentin and relieved pain for a mean duration of 17.25±2.95 months. Twenty three percent of the patients (23%) required peripheral neurectomy. Conclusions: Carbamazepine was found to be highly effective in trigeminal neuralgia. Other treatment modality includes add-on of gabapentin, neurolytic alcohol blocs and peripheral surgical intervention in more refractory cases. Only limited cases needed further neurological consideration

A NOVEL ALGORITHM BASED ON CASCADING OF NEURAL NETWORK MODELS AND WAVELET TRANSFORM FOR IMAGE ENHANCEMENT.

Image enhancement and restoration is pre-request of computer vision. The distortion and degradation of image suffered the process of pattern matching and quality of image. Wavelet is very important transform function play a role in image enhancement and image de-noising. The concept of wavelet used as soft thresholding and hard thresholding. A processing of data through wavelet is very efficient in process of neural network. In this paper we discuss the proposed algorithm for image enhancement based on self organized map network and wavelet transform. Basically self organized map network is unsupervised training mechanisms of pattern, due to this reason the processing of network is very fast in compression of another artificial neural network method. And the combination of wavelet and self organized map network have great advantage over conventional method such as histogram equalization and multi-point histogram equalization and another conventional technique of image enhancement

EFFECT OF CONVOLVULUS PLURICAULIS EXTRACT ON CAFETERIA DIET INDUCED OBESITY IN MICE

ObjectiveTo evaluate the anti  obesity effect of extract of Convolvulus pluricaulis in mice feed withcafeteria diet   MethodsObesity was induced in mice by feeding them a  daily for fourty one days in addition to normaldiet. Body weight and food intake was measured initially and then every week thereafter.On day fourty onefourty one serum biochemical parameter were measured and animal were sacrificedusing overdose of ether. The liver kidney fourty one heart and spleen were removed and weighedimmediately.Results may leads to obesity in mice however standard Sibutramine. Treatment with extractsof Convolvulus pluricaulis caused changes in the blood parameter including decease levelsof total cholesterol  TC fourty one low density lipoprotein cholesterol LDL C and TG but increasedhigh density lipoprotein cholesterolConclusionMethanolic extract of Convolvulus pluricaulis is a potential source of anti  obesityphytomedicine.Keywords  Antiobesityfourty one Convolvulus pluricaulisfourty one Shankhpushpifourty one Obesityfourty one Phytomedicine.   Â

A COMPLETE AND UPDATED REVIEW ON VARIOUS TYPES OF DRUG DELIVERY SYSTEMS

The World of medicine has gained considerable interest in the research area all over the World. Scientists constantly work on the three parameters ‘Quality, Safety, Efficacy’ of a pharmaceutical ingredient. Refine these parameters; they are continually developing different dosage forms. These unique types of dosage forms help to provide improved bioavailability and efficacy of a pharmaceutical ingredient. The role of dosage form is to improve the availability of the medicine to treat the symptoms and disease. This article focus on the different types of dosage forms, their advantages and some important facts related to that dosage forms

Optimization and Evaluation of Desloratadine Oral Strip: An Innovation in Paediatric Medication

Patients, especially children, are the most difficult to treat in all groups of population mainly because they can not swallow the solid dosage form. Due to this reason they are often prescribed liquid dosage forms. But these formulations have their own disadvantages (lack of dose accuracy during administration, spitting by children, spillage, lack of stability, difficulty in transportation, etc.). Oral strip technology is one such technology to surpass these disadvantages. Desloratadine, a descarboethoxy derivative of loratadine, is a second generation antihistaminic drug approved for usage in allergic rhinitis among paediatric population and is available in markets as suspension. An attempt has been made to design and optimize the oral strip containing desloratadine as an active ingredient. Oral strip was optimized with the help of optimal experimental design using polymer concentration, plasticizer type, and plasticizer concentration as independent variables. Prepared oral strips were evaluated for physicochemical parameter, mechanical strength parameters, disintegration time, dissolution, surface pH, and moisture sorption tendency. Optimized formulation was further evaluated by scanning electron microscopy, moisture content, and histological alteration in oral mucosa. Accelerated stability studies were also carried out for optimized formulations. Results were analysed with the help of various statistical tools at and

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Bioactivity and corrosion analysis of thermally sprayed hydroxyapatite based coatings

Metallic biomaterials have been used to repair and replace human body parts because of their excellent biocompatibility, strong corrosion resistance, and high mechanical properties. A ceramic biomaterial that is highly suitable for coating on metallic biomaterials is hydroxyapatite. This is because it is biocompatible with synthetic and natural bone tissue. There has been a growing interest in HAp-based coatings using thermal spray techniques to enhance the crystallinity and adhesion quality and produce a dense coating of metallic biomaterials. Thermally sprayed coating material has been studied and reviewed in detail in the bioactivity analysis and electro-corrosion analysis. Furthermore, the bioactivity of HAp coatings is determined by their ability to promote bone formation and osseointegration and a valuable understanding of the mechanisms and current advancements in bioactivity. Additionally, the corrosion behaviour of thermally sprayed HAp coatings under simulated conditions has been reviewed