Neuroethics and Spanish Literary Responses to "la crisis"

El ensayo trata la posibilidad de cambiar la ética social a través del discurso del humanismo. Se subraya la base genética del comportamiento del ser humano, y la influencia que el medio ambiente puede tener sobre esto. Tomando como punto de partida la narrativa, y específicamente dos novelas españolas contemporáneos, se concluye que la narrativa ejerce una función de suma importancia en el desarrollo social, pero que dicha función es más allá del control del individuo artista, y que la ética es ex post facto, o sea producida por la narrativa, y no al revés.El ensayo trata la posibilidad de cambiar la ética social a través del discurso del humanismo. Se subraya la base genética del comportamiento del ser humano, y la influencia que el medio ambiente puede tener sobre esto. Tomando como punto de partida la narrativa, y específicamente dos novelas españolas contemporáneos, se concluye que la narrativa ejerce una función de suma importancia en el desarrollo social, pero que dicha función es más allá del control del individuo artista, y que la ética es ex post facto, o sea producida por la narrativa, y no al revés.This essay treats the possibility of changing ethical behavior through the influence of humanistic discourse. The focus herein is on the genetic base of human behavior, and the influence the environment has upon it. Taking narrative as a point of departure, specifically two contemporary Spanish novels, the paper concludes that narrative exercises an determining role in social development, but a role that is beyond the conscious control of the individual. Furthermore, ethics seem to be an ex post facto product of narrative, rather than the other way round

The Fractional OU Process: Term Structure Theory and Application

The paper revisits dynamic term structure models (DTSMs) and proposes a new way in dealing with the limitation of the classical affine models. In particular, this paper expands the flexibility of the DTSMs by applying a fractional Brownian motion as the governing force of the state variable instead of the standard Brownian motion. This is a new direction in pricing non defaultable bonds with offspring in the arbitrage free pricing of weather derivatives based on fractional Brownian motions. By applying fractional Ito calculus and a fractional version of the Girsanov transform, a no arbitrage price of the bond is recovered by solving a fractional version of the fundamental bond pricing equation. Besides this theoretical contribution, the paper proposes an estimation methodology based on the Kalman filter approach, which is applied to the US term structure of interest ratesFractional bond pricing equation, fractional Brownian motion, fractional Ornstein-Uhlenbeck process, long memory, Kalman Filter

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects

The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood. Studies conducted in nonhepatic tissues demonstrated defective cellular recognition and metabolism of LDL in these patients. Since mammalian liver removes at least half of the LDL in the circulation, the metabolism of LDL by cultured hepatocytes isolated from familial hypercholesterolemic homozygotes was compared to hepatcytes from normal individuals. Fibroblast studies demonstrated that the familial hypercholesterolemic subjects studied were LDL receptor-negative (less than 1% normal receptor activity) and LDL receptor-de fective (18% normal receptor activity). Cholesterol-depleted hepatocytes from normal subjects bound and internalized 125I-labeled LDL (Bmax = 2.2 μg LDL/mg cell protein). Preincubation of normal hepatocytes with 200 μg/ml LDL reduced binding and internalization by approx. 40%. In contrast, 125I-labeled LDL binding and internalization by receptor-negative familial hypercholesterolemic hepatocytes was unaffected by cholesterol loading and considerably lower than normal. This residual LDL uptake could not be ascribed to fluid phase endocytosis as determined by [14C]sucrose uptake. The residual LDL binding by familial hypercholesterolemia hepatocytes led to a small increase in hepatocyte cholesterol content which was relatively ineffective in reducing hepatocyte 3-hydroxy-3-methylglutaryl-CoA reductase activity. Receptordefective familial hypercholesterolemia hepatocytes retained some degree of regulatable 125I-labeled LDL uptake, but LDL uptake did not lead to normal hepatocyte cholesterol content or 3-hydroxy-3-methylglutaryl-CoA reductase activity. These combined results indicate that the LDL receptor abnormality present in familial hypercholesterolemia fibroblasts reflects deranged hepatocyte LDL recognition and metabolism. In addition, a low-affinity, nonsaturable uptake process for LDL is present in human liver which does not efficiently modulate hepatocyte cholesterol content or synthesis. © 1986

Effect of changing flushing rates on development of late summer Aphanizomenon and Microcystis populations in a shallow lake, Müggelsee, Berlin, Germany

Müggelsee is a shallow lake in the suburban region of Berlin, Germany and included in the lake-river system of the river Spree, having an average annual retention time of 42 days which increases to > 100 days in the summer period. The summer equilibrium phase of phytoplankton results in the development of an Aphanizomenon flos-aquae dominated assemblage which, in some years, progresses towards a Microcystis dominated assemblage. Continuously high flushing (in range of 1%-2% of lake volume day (-1) does not prevent Aphanizomenon development but its biomass remains at low levels as compared to other summers with smaller average flushing. In such years (flushing remains < 1% of lake volume day (-1)) a flushing pulse of 1%-2% of lake volume day (-1) has been effectual to break development of cyanoprokaryotes and to decrease their biomass to low levels. The major reason of the decrease is not the dilution effect of flushing pulses but the intolerance of cyanoprokaryotes to sudden environmental changes. Considering the case of Müggelsee from the point of view of reservoir ecology it can be concluded that reservoirs with pulsed use are less exposed to development of cyanoprokaryotes if pulses occur in a sufficient frequency (20-30 days) and their intensity falls to the range of 1%-2% of reservoir volume day(-1). Reservoirs with continuous take off of water are more exposed to cyanoprokaryota development with all the consequences for water use

Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects

Patients with familial hypercholesterolemia have elevated levels of plasma low density lipoproteins (LDL), increased hepatic synthesis of apolipoprotein B-containing lipoproteins, defective binding of low density lipoproteins to fibroblasts, and premature atherosclerosis. The role of a hepatic low density lipoprotein receptor in normal man and its importance in the pathogenesis of familial hypercholesterolemia have not been previously determined. In the present study, direct comparison was made of the binding of LDL to hepatic membranes from normal and receptor-negative homozygous familial hypercholesterolemic subjects. The effects of calcium, EDTA, and temperature on the binding of lipoproteins to the hepatic membranes were also evaluated. At 4°C, no significant difference in specific binding of LDL to hepatic membranes from normal and familial hypercholesterolemic subjects was observed. At 37°C, both total and specific binding of LDL were significantly reduced in patients with familial hypercholesterolemia. Hepatic membrane binding of LDL from the two patients homozygous for receptor-negative familial hypercholesterolemia was 53 and 59% of normal. The activity of the rate-limiting enzyme in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase was normal; however, the total hepatic cholesterol and cholesteryl ester content was significantly increased from 53 to 129%. These results indicate that patients with familial hypercholesterolemia have a defect in the interaction of hepatic membranes with low density lipoproteins. This defect may lead to accelerated atherosclerosis by decreasing the cellular catabolism of LDL and enhancing the production of LDL, which is characteristic of patients homozygous for familial hypercholesterolemia

The Large Quasar Reference Frame (LQRF) - an optical representation of the ICRS

The large number and all-sky distribution of quasars from different surveys, along with their presence in large, deep astrometric catalogs,enables the building of an optical materialization of the ICRS following its defining principles. Namely: that it is kinematically non-rotating with respect to the ensemble of distant extragalactic objects; aligned with the mean equator and dynamical equinox of J2000; and realized by a list of adopted coordinates of extragalatic sources. Starting from the updated and presumably complete LQAC list of QSOs, the initial optical positions of those quasars are found in the USNO B1.0 and GSC2.3 catalogs, and from the SDSS DR5. The initial positions are next placed onto UCAC2-based reference frames, following by an alignment with the ICRF, to which were added the most precise sources from the VLBA calibrator list and the VLA calibrator list - when reliable optical counterparts exist. Finally, the LQRF axes are inspected through spherical harmonics, contemplating to define right ascension, declination and magnitude terms. The LQRF contains J2000 referred equatorial coordinates for 100,165 quasars, well represented across the sky, from -83.5 to +88.5 degrees in declination, and with 10 arcmin being the average distance between adjacent elements. The global alignment with the ICRF is 1.5 mas, and the individual position accuracies are represented by a Poisson distribution that peaks at 139 mas in right ascension and 130 mas in declination. It is complemented by redshift and photometry information from the LQAC. The LQRF is designed to be an astrometric frame, but it is also the basis for the GAIA mission initial quasars' list, and can be used as a test bench for quasars' space distribution and luminosity function studies.Comment: 23 pages, 23 figures, 6 tables Accepted for publication by Astronomy & Astrophysics, on 25 May 200

The Na I D resonance lines in main sequence late-type stars

We study the sodium D lines (D1: 5895.92 \AA; D2: 5889.95 \AA) in late-type dwarf stars. The stars have spectral types between F6 and M5.5 (B-V between 0.457 and 1.807) and metallicity between [Fe/H] = -0.82 and 0.6. We obtained medium resolution echelle spectra using the 2.15-m telescope at the argentinian observatory CASLEO. The observations have been performed periodically since 1999. The spectra were calibrated in wavelength and in flux. A definition of the pseudo-continuum level is found for all our observations. We also define a continuum level for calibration purposes. The equivalent width of the D lines is computed in detail for all our spectra and related to the colour index (B-V) of the stars. When possible, we perform a careful comparison with previous studies. Finally, we construct a spectral index (R_D') as the ratio between the flux in the D lines, and the bolometric flux. We find that, once corrected for the photospheric contribution, this index can be used as a chromospheric activity indicator in stars with a high level of activity. Additionally, we find that combining some of our results, we obtain a method to calibrate in flux stars of unknown colour.Comment: 12 pages, including 14 figures and 4 tables. Accepted for publication in MNRA