Fire resistance of cold‐formed steel framed shear walls under various fire scenarios

This paper presents results of large-scale experiments with varying levels of fire severity on lateral force-resisting systems commonly used in cold-formed steel framed buildings. Gypsum-sheet steel composite panel sheathed walls, oriented strand board sheathed walls, and steel strap-braced walls are examined. Postflashover fire conditions of two different intensities as well as 1 hour of fire exposure similar to that in a standard furnace qualification test are studied. Additionally, a full-scale furnished kitchen fire experiment is conducted for comparison. The results highlight differences in the thermal response and subsequent performance of the walls as well as differing sensitives of the walls to pre-damage, eg, that might occur during an earthquake. The results are part of a larger effort to provide fragilities for these wall systems in response to realistic fires for performance-based design

Energy efficiency trade-offs drive nucleotide usage in transcribed regions

Efficient nutrient usage is a trait under universal selection. A substantial part of cellular resources is spent on making nucleotides. We thus expect preferential use of cheaper nucleotides especially in transcribed sequences, which are often amplified thousand-fold compared with genomic sequences. To test this hypothesis, we derive a mutation-selection-drift equilibrium model for nucleotide skews (strand-specific usage of ‘A' versus ‘T' and ‘G' versus ‘C'), which explains nucleotide skews across 1,550 prokaryotic genomes as a consequence of selection on efficient resource usage. Transcription-related selection generally favours the cheaper nucleotides ‘U' and ‘C' at synonymous sites. However, the information encoded in mRNA is further amplified through translation. Due to unexpected trade-offs in the codon table, cheaper nucleotides encode on average energetically more expensive amino acids. These trade-offs apply to both strand-specific nucleotide usage and GC content, causing a universal bias towards the more expensive nucleotides ‘A' and ‘G' at non-synonymous coding sites

Microbial life and biogeochemical cycling on land 3,220 million years ago

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