Effect of Carbon Sources and Carbonaceous Atmospheres on the Effective Synthesis of Nanostructured Tungsten Carbide Powders

Owing to its ultra-fine microstructure, nanostructured tungsten carbide (WC) powders characterized by advanced mechanical properties are of highest in terest for the metal cutting industry where they are used for the production of cemented carbide cutting tools. In this work, WC synthesis from precursor mixes containing tungsten powder (in form of W or WO3 powder) and carbon sources (as graphite orcarbon black) is achieved by a two-step process. Mechanical activation by ball milling of the precursor powders is followed by thermal activation at 1100°C for 30 min in Ar or Ar-10%CO atmospheres. Depending on the tungsten source (W or WO3 powder) solid carbon provides either solely carburization, or both reduction and carburization, which can be assisted by the presence of CO in the synthesis atmosphere. The results show that homogeneous, fine mixes of the base powders after milling offer large contact area and improve reactivity between the precursors. Synthesis of pure WC powders is achieved at 1100 ⁰C in inert Ar atmosphere when using metallic tungsten as precursor. Using oxide precursors (WO3), synthesis is not completed at 1100 ⁰C in Ar atmosphere, however, a significant improvement in the efficiency of the synthesis is achieved when using Ar-10%CO atmospheres. Although the reducing activity of CO seems to be low in the conditions studied in this work, improved carburization of metallic tungsten by CO might be the key for improving efficiency of the synthesis process

Don\u27t Bite The Hand That\u27s Feeding You

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The effect of different training modes on skeletal muscle microvascular density and endothelial enzymes controlling NO availability

It is becoming increasingly apparent that a high vasodilator response of the skeletal muscle microvasculature to insulin and exercise is of critical importance for adequate muscle perfusion and long-term microvascular and muscle metabolic health. Previous research has shown that a sedentary lifestyle, obesity, and ageing lead to impairments in the vasodilator response, while a physically active lifestyle keeps both microvascular density and vasodilator response high. To investigate the molecular mechanisms behind these impairments and the benefits of exercise training interventions, our laboratory has recently developed quantitative immunofluorescence microscopy methods to measure protein content of eNOS and NAD(P)Hoxidase specifically in the endothelial layer of capillaries and arterioles of human skeletal muscle. As eNOS produces NO and NAD(P)Hoxidase superoxide anions (quenching NO) we propose that the eNOS/NAD(P)Hoxidase protein ratio is a marker of vasodilator capacity. The novel methods show that endurance training (ET) and high intensity interval training (HIT) generally regarded as a time efficient alternative to ET, increase eNOS protein content and the eNOS/NADP(H) oxidase protein ratio in previously sedentary lean and obese young men. Resistance exercise training had smaller but qualitatively similar effects. Western blot data of other laboratories suggest that endurance exercise training leads to similar changes in sedentary elderly men. Future research will be required to investigate the relative importance of other sources and tissues in the balance between NO and O2- production seen by the vascular smooth muscle layer of terminal arterioles

On assessing grindability of recycled and ore-based crankshaft steel: an approach combining data analysis with material science

Material-related grindability variations when grinding recycled and ore-based steel can significantly impair the process efficiency during finishing of automotive crankshafts. To address this problem and to achieve more robust grinding processes, the underlying causes of variation need to be understood. The present work investigates the feasibility of using quality data obtained during production to study grindability variations and identify material-related effects. Analysis of non-destructive inspection protocols indicates steel supplier-dependent differences in grindability. However, no systematic grindability differences between recycled and ore-based steel could be identified. Possible correlations between grindability and material characteristics obtained from supplied steel certificates are discussed

EGF Signal Propagation during C. elegans Vulval Development Mediated by ROM-1 Rhomboid

During Caenorhabditis elegans vulval development, the anchor cell (AC) in the somatic gonad secretes an epidermal growth factor (EGF) to activate the EGF receptor (EGFR) signaling pathway in the adjacent vulval precursor cells (VPCs). The inductive AC signal specifies the vulval fates of the three proximal VPCs P5.p, P6.p, and P7.p. The C. elegans Rhomboid homolog ROM-1 increases the range of EGF, allowing the inductive signal to reach the distal VPCs P3.p, P4.p and P8.p, which are further away from the AC. Surprisingly, ROM-1 functions in the signal-receiving VPCs rather than the signal-sending AC. This observation led to the discovery of an AC–independent activity of EGF in the VPCs that promotes vulval cell fate specification and depends on ROM-1. Of the two previously reported EGF splice variants, the longer one requires ROM-1 for its activity, while the shorter form acts independently of ROM-1. We present a model in which ROM-1 relays the inductive AC signal from the proximal to the distal VPCs by allowing the secretion of the LIN-3L splice variant. These results indicate that, in spite of their structural diversity, Rhomboid proteins play a conserved role in activating EGFR signaling in C. elegans, Drosophila, and possibly also in mammals

cGAL, a temperature-robust GAL4–UAS system for Caenorhabditis elegans

The GAL4–UAS system is a powerful tool for manipulating gene expression, but its application in Caenorhabditis elegans has not been described. Here we systematically optimize the system's three main components to develop a temperature-optimized GAL4–UAS system (cGAL) that robustly controls gene expression in C. elegans from 15 to 25 °C. We demonstrate this system's utility in transcriptional reporter analysis, site-of-action experiments and exogenous transgene expression; and we provide a basic driver and effector toolkit

Investigation of micro-textured cutting tools used for face turning of alloy 718 with high-pressure cooling

There is an increasing demand to improve the service life of cutting tools during machining of heat resistant superalloys (HRSA). Various studies showed that textured cutting tools improved the tribological properties and reduced cutting forces, temperature, and tool wear. Surface texturing can be seen as a futuristic design to improve the performance of the cutting tool and to increase productivity. However, only limited research has been conducted in machining superalloys with textured inserts and high-pressure coolant. In this work, three different micro texture designs on both rake and flank face are investigated in combination with high-pressure coolant in machining Alloy 718. Due to better tool life predictability, carbide cutting tools are used in machining components made from superalloys. However, the disadvantage is that machining can only be done at lower cutting speed/feed rate/depth of cut with high tool wear rates. The experimental investigation using different tool wear analysis methods showed that the combination of a cylindrical dimple on the rake and the square pyramid texture on the flank surface improved the wear resistance of the tool. An increase in tool life of about 30% was achieved as compared with a regular insert for the investigated cutting conditions. Different levels of adhering workpiece material were observed on the rake face of textured tools. Furthermore, the chip backside showed imprints from the tool textures. The tool textures on the rake face have influenced the tool-chip friction conditions during cutting

The faradaic efficiency of the lithium-thionyl chloride battery

The efficiency of converting chemical energy into electrical energy has been studied for the case of D-size, low and medium rate lithium-thionyl chloride (Li/TC) cells, under DC and various pulsed loads. Microcalorimetric monitoring of the heat output during discharge allowed the direct measurement of the faradaic efficiency, and showed that self-discharge is far more pervasive than previously acknowledged by researchers and battery manufacturers. Evaluations of the cell dynamics prove that current load and temperature fluctuations combine to disrupt the lithium passivation and to greatly enhance self-discharge. Typical faradaic efficiencies for DC range from abut 30% at low current density to 90% at moderate and 75% at high current density. Pulsed current further depresses these efficiency levels, except at very low average current densities. The decreased faradaic efficiency of Li/TC batteries in certain pulse situations needs to be studied further to define the range of applications for which it can be successfully used

Physics-based approach for predicting dissolution‒diffusion tool wear in machining

A new approach is proposed to predict the thermally-activated dissolution-diffusion wear of carbide tools. Departing from the iterative procedure used for such nonlinear processes, a direct response surface approach that correlates the cutting conditions and wear level to the interface temperature is presented. For prediction of wear evolution, a calibrated thermodynamic model that describes chemical interaction between the tool and workpiece materials is combined with the FE simulation of machining process, considering the pressure-dependent thermal constriction resistance phenomenon. The accuracy of predicting flank wear in turning C50 plain carbon steel ‒ where dissolution-diffusion wear mechanism prevails ‒ is validated experimentally

A humanized version of Foxp2 affects ultrasonic vocalization in adult female and male mice

Abstract The transcription factor FoxP2 is involved in setting up the neuronal circuitry for vocal learning in mammals and birds and is thought to have played a special role in the evolution of human speech and language. It has been shown that an allele with a humanized version of the murine Foxp2 gene changes the ultrasonic vocalization of mouse pups compared to pups of the wild-type inbred strain. Here we tested if this humanized allele would also affect the ultrasonic vocalization of adult female and male mice. In a previous study, in which only male vocalization was considered and the mice were recorded under a restricted spatial and temporal regime, no difference in adult vocalization between genotypes was found. Here, we use a different test paradigm in which both female and male vocalizations are recorded in extended social contact. We found differences in temporal, spectral and syntactical parameters between the genotypes in both sexes, and between sexes. Mice carrying the humanized Foxp2 allele were using higher frequencies and more complex syllable types than mice of the corresponding wildtype inbred strain. Our results support the notion that the humanized Foxp2 allele has a differential effect on mouse ultrasonic vocalization. As mice carrying the humanized version of the Foxp2 gene show effects opposite to those of mice carrying disrupted or mutated alleles of this gene, we conclude that this mouse line represents an important model for the study of human speech and language evolution