Phenolic Contents and Compositions in Skins of Red Wine Grape Cultivars among Various Genetic Backgrounds and Originations

In order to analyze and compare the phenolic characteristics of red wine grapes with diverse genetic backgrounds, skin phenolics among 21 different cultivars belonging to Vitis vinifera L., East Asian and North American Vitis species and hybrids, as well as 2 varieties of muscadine grapes were estimated by HPLC-MS/MS. There were 45 anthocyanins, 28 flavonols, 8 flavan-3-ols, 9 cinnamic acids, 5 benzoic acids, 5 ellagic acids and 2 stilbenes detected in all the samples. Total contents of each phenolic type varied significantly among the different grape cultivars investigated. There was also a large variability in the phenolic compositions of different grape groups. The differences in anthocyanin composition were obvious between V. vinifera and non-V. vinifera grapes and also between the grapes originating from Eurasia and North America. Quercetin-3-glucuronide and quercetin-3-glucoside were marker flavonol compounds for Euvitis grape skins. Flavan-3-ol monomers were dominant in the skins of muscadine and non-V. amurensis East Asian grapes, whereas polymers were more common in V. vinifera and North American grapes. The muscadine grapes were very rich in flavonols, flavan-3-ols and ellagic acids. Via principal component analysis, these grape cultivars were clustered into three groups according to their characteristic phenolic content and composition

Performance comparison of electrospray ionization and atmospheric pressure chemical ionization in untargeted and targeted liquid chromatography/mass spectrometry based metabolomics analysis of grapeberry metabolites

Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are both used to generate ions for the analysis of metabolites by liquid chromatography/mass spectrometry (LC/MS). We compared the performance of these methods for the analysis of Corvina grapevine berry methanolic extracts, which are complex mixtures of diverse metabolites

Intérêt du monitorage de la saturation veineuse centrale en oxygène dans la prise en charge du choc septique en réanimation

Le choc septique est caractérisé par l intrication de nombreux mécanismes qui concourent à l installation d une défaillance multiviscérale. La prise en charge de la défaillance hémodynamique précoce est importante. Des mesures répétées de la saturation veineuse centrale et du lactate sont recommandées pour évaluer la sévérité de l état de choc. Toutefois, il existe peu de données récentes en réanimation pour apprécier la validité de ces recommandations. La SvcO2 semble être un témoin de l adéquation entre le transport et les besoins tissulaires en oxygène. Nous avons réalisé une étude prospective où il apparaît que la SvcO2 et le lactate ont une valeur pronostique sur la mortalité hospitalière. Leur surveillance en réanimation apparaît donc intéressante pour définir précocement la sévérité d un patient en choc septique.NANTES-BU Médecine pharmacie (441092101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

5-fluorouracile et 5-fluorocytosine (synthèse et étude de dérivés nucléosidiques et pronucléotidiques à visées antitumorale et antivirale)

MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF

Impact pronostique du CD38 dans la leucémie lymphoïde chronique ( à propos de 62 cas )

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF