A Maxwell-vector p-wave holographic superconductor in a particular background AdS black hole metric

We study the p-wave holographic superconductor for AdS black holes with planar event horizon topology for a particular Lovelock gravity, in which the action is characterized by a self-interacting scalar field nonminimally coupled to the gravity theory which is labeled by an integer $k$. As the Lovelock theory of gravity is the most general metric theory of gravity based on the fundamental assumptions of general relativity, it is a desirable theory to describe the higher dimensional spacetime geometry. The present work is devoted to studying the properties of the p-wave holographic superconductor by including a Maxwell field which nonminimally couples to a complex vector field in a higher dimensional background metric. In the probe limit, we find that the critical temperature decreases with the increase of the index $k$ of the background black hole metric, which shows that a larger $k$ makes it harder for the condensation to form. We also observe that the index $k$ affects the conductivity and the gap frequency of the holographic superconductors.Comment: 14 pages, 6 figure

p-wave holographic superconductor in scalar hairy black holes

We study the properties of the p-wave holographic superconductor for the scalar hairy black holes in the probe limit. The black hole solutions in question possess planar topology, which are derived from the Einstein gravity theory minimally coupled to a scalar field with a generic scalar potential. These solutions can be viewed as characterized by two independent parameters, namely, $\alpha$ and $k_0$, where AdS vacuum is manifestly restored when $\alpha\to \infty$. Consequently, the p-wave holographic superconductor is investigated by employing the above static planar black hole spacetime as the background metric, where a Maxwell field is introduced to the model by nonminimally coupling it to a complex vector field. The latter is shown to condensate and furnish the superconducting phase when the temperature is below a critical value. By numerical calculations, we examine in detail how the scalar field in the background affects the properties of the superconductivity. It is found that the critical temperature depends crucially on the parameters $\alpha$ and $k_0$, which subsequently affects the condensation process. By employing the Kubo formula, the real, as well as imaginary parts of the conductivity, are calculated and presented as functions of frequency. The results are discussed regarding the poles of the Green function, and the typical values of the BCS theory.Comment: 15 pages, 6 figure

Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival.

Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits further exploration. In the present study, we show that Salmonella can exploit mammalian cell non-classical microRNA processing machinery to further process bacterial small non-coding RNAs into microRNA-like fragments. Sal-1, one such fragment with the highest copy number in the infected cells, is derived from Salmonella 5-leader of the ribosomal RNA transcript and has a stem structure-containing precursor. Processing of Sal-1 precursors to mature Sal-1 is dependent on host cell Argonaute 2 (AGO2) but not Dicer. Functionally, depleting cellular Sal-1 strongly renders the Salmonella bacteria less resistant to the host defenses both in vitro and in vivo. In conclusion, we demonstrate a novel strategy for Salmonella evading the host immune clearance, in which Salmonella produce microRNA-like functional RNA fragments to establish a microenvironment facilitating bacterial survival

Regulation of Voltage-Gated Ca2+ Currents by Ca2+/Calmodulin-dependent Protein Kinase II in Resting Sensory Neurons

Calcium/calmodulin-dependent protein kinase II (CaMKII) is recognized as a key element in encoding depolarization activity of excitable cells into facilitated voltage-gated Ca2+ channel (VGCC) function. Less is known about the participation of CaMKII in regulating VGCCs in resting cells. We examined constitutive CaMKII control of Ca2+ currents in peripheral sensory neurons acutely isolated from dorsal root ganglia (DRGs) of adult rats. The small molecule CaMKII inhibitor KN-93 (1.0μM) reduced depolarization-induced ICa by 16 – 30% in excess of the effects produced by the inactive homolog KN-92. The specificity of CaMKII inhibition on VGCC function was shown by efficacy of the selective CaMKII blocking peptide autocamtide-2-related inhibitory peptide in a membrane-permeable myristoylated form, which also reduced VGCC current in resting neurons. Loss of VGCC currents is primarily due to reduced N-type current, as application of mAIP selectively reduced N-type current by approximately 30%, and prior N-type current inhibition eliminated the effect of mAIP on VGCCs, while prior block of L-type channels did not reduce the effect of mAIP on total ICa. T-type currents were not affected by mAIP in resting DRG neurons. Transduction of sensory neurons in vivo by DRG injection of an adeno-associated virus expressing AIP also resulted in a loss of N-type currents. Together, these findings reveal a novel molecular adaptation whereby sensory neurons retain CaMKII support of VGCCs despite remaining quiescent

CaMKII Controls Whether Touch Is Painful

The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is evident in the process of adaption, in which a period of diminished sensitivity follows prior stimulation. CaMKII is an ideal candidate for mediating activity-dependent plasticity in touch because it shifts into an enhanced activation state after neuronal depolarizations and can thereby reflect past firing history. Here we show that sensory neuron CaMKII autophosphorylation encodes the level of Aβ-LTMR activity in rat models of sensory deprivation (whisker clipping, tail suspension, casting). Blockade of CaMKII signaling limits normal adaptation of action potential generation in Aβ-LTMRs in excised skin. CaMKII activity is also required for natural filtering of impulse trains as they travel through the sensory neuron T-junction in the DRG. Blockade of CaMKII selectively in presynaptic Aβ-LTMRs removes dorsal horn inhibition that otherwise prevents Aβ-LTMR input from activating nociceptive lamina I neurons. Together, these consequences of reduced CaMKII function in Aβ-LTMRs cause low-intensity mechanical stimulation to produce pain behavior. We conclude that, without normal sensory activity to maintain adequate levels of CaMKII function, the touch pathway shifts into a pain system. In the clinical setting, sensory disuse may be a critical factor that enhances and prolongs chronic pain initiated by other conditions. SIGNIFICANCE STATEMENT: The sensation of touch is served by specialized sensory neurons termed low-threshold mechanoreceptors (LTMRs). We examined the role of CaMKII in regulating the function of these neurons. Loss of CaMKII function, such as occurred in rats during sensory deprivation, elevated the generation and propagation of impulses by LTMRs, and altered the spinal cord circuitry in such a way that low-threshold mechanical stimuli produced pain behavior. Because limbs are protected from use during a painful condition, this sensitization of LTMRs may perpetuate pain and prevent functional rehabilitation

New bounds for bb-Symbol Distances of Matrix Product Codes

Matrix product codes are generalizations of some well-known constructions of codes, such as Reed-Muller codes, $[u+v,u-v]$-construction, etc. Recently, a bound for the symbol-pair distance of a matrix product code was given in \cite{LEL}, and new families of MDS symbol-pair codes were constructed by using this bound. In this paper, we generalize this bound to the $b$-symbol distance of a matrix product code and determine all minimum $b$-symbol distances of Reed-Muller codes. We also give a bound for the minimum $b$-symbol distance of codes obtained from the $[u+v,u-v]$-construction, and use this bound to construct some $[2n,2n-2]_q$-linear $b$-symbol almost MDS codes with arbitrary length. All the minimum $b$-symbol distances of $[n,n-1]_q$-linear codes and $[n,n-2]_q$-linear codes for $1\leq b\leq n$ are determined. Some examples are presented to illustrate these results

Refractive index in generalized superconductors with Born-Infeld electrodynamics

We investigate, in the probe limit, the negative refraction in the generalized superconductors with the Born-Infeld electrodynamics. We observe that the system has a negative Depine-Lakhtakia index in the superconducting phase at small frequencies and the greater the Born-Infeld corrections the larger the range of frequencies or the range of temperatures for which the negative refraction occurs. Furthermore, we find that the tunable Born-Infeld parameter can be used to improve the propagation of light in the holographic setup. Our analysis indicates that the Born-Infeld electrodynamics plays an important role in determining the optical properties of the boundary theory.Comment: 13 pages, 6 figure