Lemko linguistic identity: Contested pluralities

In their efforts to organize as a recognized minority within the Polish state, the Lemkos have faced a number of obstacles, both internal and external to the community. This article explores three aspects of self-representation of the Lemko community - group membership, victimhood and “speakerhood” – and examines how these representations are contested on a number of levels.National Foreign Language Resource Cente

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.

Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions. A method capable of profiling a substantial fraction of the surface proteome simultaneously and inexpensively would enable more accurate and complete classification of cell states. We present a highly multiplexed and quantitative surface proteomic method using genetically barcoded antibodies called phage-antibody next-generation sequencing (PhaNGS). Using 144 preselected antibodies displayed on filamentous phage (Fab-phage) against 44 receptor targets, we assess changes in B cell surface proteins after the development of drug resistance in a patient with acute lymphoblastic leukemia (ALL) and in adaptation to oncogene expression in a Myc-inducible Burkitt lymphoma model. We further show PhaNGS can be applied at the single-cell level. Our results reveal that a common set of proteins including FLT3, NCR3LG1, and ROR1 dominate the response to similar oncogenic perturbations in B cells. Linking high-affinity, selective, genetically encoded binders to NGS enables direct and highly multiplexed protein detection, comparable to RNA-sequencing for mRNA. PhaNGS has the potential to profile a substantial fraction of the surface proteome simultaneously and inexpensively to enable more accurate and complete classification of cell states

AXTAR: Mission Design Concept

The Advanced X-ray Timing Array (AXTAR) is a mission concept for X-ray timing of compact objects that combines very large collecting area, broadband spectral coverage, high time resolution, highly flexible scheduling, and an ability to respond promptly to time-critical targets of opportunity. It is optimized for submillisecond timing of bright Galactic X-ray sources in order to study phenomena at the natural time scales of neutron star surfaces and black hole event horizons, thus probing the physics of ultradense matter, strongly curved spacetimes, and intense magnetic fields. AXTAR's main instrument, the Large Area Timing Array (LATA) is a collimated instrument with 2-50 keV coverage and over 3 square meters effective area. The LATA is made up of an array of supermodules that house 2-mm thick silicon pixel detectors. AXTAR will provide a significant improvement in effective area (a factor of 7 at 4 keV and a factor of 36 at 30 keV) over the RXTE PCA. AXTAR will also carry a sensitive Sky Monitor (SM) that acts as a trigger for pointed observations of X-ray transients in addition to providing high duty cycle monitoring of the X-ray sky. We review the science goals and technical concept for AXTAR and present results from a preliminary mission design study.Comment: 19 pages, 10 figures, to be published in Space Telescopes and Instrumentation 2010: Ultraviolet to Gamma Ray, Proceedings of SPIE Volume 773

Calls to Leadership

Below is a document containing the combined remarks delivered by the following representatives from across the Illinois Wesleyan community:From the Board – Deon Hornsby ’97, Board of TrusteesFrom a Presidential Perspective – Richard F. Wilson, President EmeritusFrom Alumni – Elly Jones ’91, President of the Alumni AssociationFrom Faculty – Michael B. Young, Robert W. Harrington Endowed Professor of HistoryFrom Staff – Eric Gordon, 2015 Max Starkey Service Award recipientFrom Students – Lane Bennett ’18, President of Student Senate The speakers\u27 photographs and their remarks are also available for download here. A video of the ceremony is available at https://youtu.be/p4tqbmQALeQ?t=20m59shttps://digitalcommons.iwu.edu/jensen_inauguration/1004/thumbnail.jp