Multi-spectral window radiance observations of Cirrus from satellite and aircraft, November 2, 1986 Project FIRE

High resolution infrared radiance spectra achieved from the NASA ER2 airborne HIS experiment are used to analyze the spectral emissivity properties of cirrus clouds within the 8 to 12 micron atmospheric window region. Observations show that the cirrus emissivity generally decreases with increasing wavenumber (i.e., decreasing wavelength) within this band. A very abrupt decrease in emissivity (increase in brightness temperature) exists between 930/cm (10.8 microns) and 1000/cm (10.0 microns), the magnitude of the change being associated with the cirrus optical thickness as observed by lidar. The HIS observations are consistent with theoretical calculations of the spectral absorption coefficient for ice. The HIS observations imply that cirrus clouds can be detected unambiguously from the difference in brightness temperatures observed within the 8.2 and 11.0 micron window regions of the HIRS sounding radiometer flying on the operational NOAA satellites. This ability is demonstrated using simultaneous 25 km resolution HIRS observations and 1 km resolution AVHRR imagery achieved from the NOAA-9 satellite. Finally, the cirrus cloud location estimates combined with the 6.7 micron channel moisture imagery portray the boundaries of the ice/vapor phase of the upper troposphere moisture. This phase distinction is crucial for infrared radiative transfer considerations for weather and climate models, since upper tropospheric water vapor has little effect on the Earth's outgoing radiation whereas cirrus clouds have a very large attenuating effect

Determinants of hospital death in haematological cancers: findings from a qualitative study

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. Objectives: Current UK health policy promotes enabling people to die in a place they choose, which for most is home. Despite this, patients with haematological malignancies (leukaemias, lymphomas and myeloma) are more likely to die in hospital than those with other cancers, and this is often considered a reflection of poor quality end-of-life care. This study aimed to explore the experiences of clinicians and relatives to determine why hospital deaths predominate in these diseases.Methods: The study was set within the Haematological Malignancy Research Network (HMRN-www.hmrn.org), an ongoing population-based cohort that provides infrastructure for evidence-based research. Qualitative interviews were conducted with clinical staff in haematology, palliative care and general practice (n=45) and relatives of deceased HMRN patients (n=10). Data were analysed for thematic content and coding and classification was inductive. Interpretation involved seeking meaning, salience and connections within the data. Results: Five themes were identified relating to: the characteristics and trajectory of haematological cancers, a mismatch between the expectations and reality of home death, preference for hospital death, barriers to home/hospice death and suggested changes to practice to support non-hospital death, when preferred. Conclusions: Hospital deaths were largely determined by the characteristics of haematological malignancies, which included uncertain trajectories, indistinct transitions and difficulties predicting prognosis and identifying if or when to withdraw treatment. Advance planning (where possible) and better communication between primary and secondary care may facilitate non-hospital death

Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I)

Purpose: To assess the role of participant-reported symptoms on long-term adherence to preventive therapy in the United Kingdom sample of the International Breast Cancer Intervention Study (IBIS-I). IBIS-I was a randomized controlled trial that investigated the effectiveness of tamoxifen in reducing the risk of breast cancer among women at increased risk of the disease. Participants and Methods: Women were randomly assigned to tamoxifen versus placebo (20 mg/day; n = 4,279). After 456 exclusions, 3,823 women were included in this analysis. Adherence (< 4.5 years or ≥ 4.5 years) was calculated using data from six monthly clinical visits. Analyses were adjusted for age, Tyrer-Cuzick risk, smoking, use of hormone replacement therapy, menopausal status, baseline menopausal symptoms, and treatment. Results: Overall, 69.7% of women were adherent for at least 4.5 years (tamoxifen: 65.2% v placebo: 74.0%; P .05). In both treatment arms, we observed significant trends for lower adherence with increasing severity for all symptoms (P < .01) except headaches (P = .054). Conclusion: In the IBIS-I trial, experiencing predefined symptoms in the first 6 months reduced long-term adherence. Effects were similar between treatment arms, suggesting that women were attributing age-related symptoms to preventive therapy. Interventions were required to support symptom management

AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells:Implications for age-associated fibrosis

Proteins in basement membrane (BM) are long-lived and accumulate chemical modifications during aging; advanced glycation end-product (AGE) formation is one such modification. The human lens capsule is a BM secreted by lens epithelial cells. In this study, we have investigated the effect of aging and cataracts on the AGE levels in the human lens capsule and determined their role in the epithelial-to-mesenchymal transition (EMT) of lens epithelial cells. EMT occurs during posterior capsule opacification (PCO), also known as secondary cataract formation. Wefound age-dependent increases in several AGEs and significantly higher levels in cataractous lens capsules than in normal lens capsules measured by LC-MS/MS. The TGFβ2-mediated upregulation of the mRNA levels (by qPCR) of EMT-associated proteins was significantly enhanced in cells cultured on AGE-modified BM and human lens capsule compared with those on unmodified proteins. Such responses were also observed for TGFβ1. In the human capsular bag model of PCO, the AGE content of the capsule proteins was correlated with the synthesis of TGFβ2-mediated a-smooth muscle actin (αSMA). Taken together, our data imply that AGEs in the lens capsule promote the TGFβ2-mediated fibrosis of lens epithelial cells during PCO and suggest that AGEs in BMs could have a broader role in aging and diabetes-associated fibrosis

KSwAGS: A Swift X-ray and UV Survey of the Kepler Field. I

We introduce the first phase of the Kepler-Swift Active Galaxies and Stars survey (KSwAGS), a simultaneous X-ray and UV survey of ~6 square degrees of the Kepler field using the Swift XRT and UVOT. We detect 93 unique X-ray sources with S/N>3 with the XRT, of which 60 have observed UV counterparts. We use the Kepler Input Catalog (KIC) to obtain the optical counterparts of these sources, and construct the X-ray to optical flux ratio as a first approximation of the classification of the source. The survey produces a mixture of stellar sources, extragalactic sources, and sources which we are not able to classify with certainty. We have obtained optical spectra for thirty of these targets, and are conducting an ongoing observing campaign to fully identify the sample. For sources classified as stellar or AGN with certainty, we construct SEDs using the 2MASS, UBV and GALEX data supplied for their optical counterparts by the KIC, and show that the SEDs differ qualitatively between the source types, and so can offer a method of classification in absence of a spectrum. Future papers in this series will analyze the timing properties of the stars and AGN in our sample separately. Our survey provides the first X-ray and UV data for a number of known variable stellar sources, as well as a large number of new X-ray detections in this well-studied portion of the sky. The KSwAGS survey is currently ongoing in the K2 ecliptic plane fields.Comment: Accepted for publication in the Astronomical Journal. 19 pages, 8 figures, 3 table

Risk Management Alternatives

Exact date of working paper unknown

Dynamic clusters (Dynamic Location of Phone Call Clusters)

When mobile handsets are making a call, a measurement report is sent to the serving base station periodically which includes the signal strengths to the base station and the next six strongest signals of the surrounding base stations. Motorola asked the Study Group if it was possible to say whether we could use this information to infer if phone calls occur in clusters and if it was possible to determine the locations, size and other features of these clusters. The Study Group found clusters in 'signal space,' that is, handsets reporting similar signal strengths with the same base stations and explored methods of locating these clusters geographically

The Kepler Light Curves of AGN: A Detailed Analysis

We present a comprehensive analysis of 21 light curves of Type 1 AGN from the Kepler spacecraft. First, we describe the necessity and development of a customized pipeline for treating Kepler data of stochastically variable sources like AGN. We then present the light curves, power spectral density functions (PSDs), and flux histograms. The light curves display an astonishing variety of behaviors, many of which would not be detected in ground-based studies, including switching between distinct flux levels. Six objects exhibit PSD flattening at characteristic timescales which roughly correlate with black hole mass. These timescales are consistent with orbital timescales or freefall accretion timescales. We check for correlations of variability and high-frequency PSD slope with accretion rate, black hole mass, redshift and luminosity. We find that bolometric luminosity is anticorrelated with both variability and steepness of the PSD slope. We do not find evidence of the linear rms-flux relationships or lognormal flux distributions found in X-ray AGN light curves, indicating that reprocessing is not a significant contributor to optical variability at the 0.1-10% level.Comment: 39 pages including 2 appendices. Accepted for Publication in the Astrophysical Journal, with higher resolution figure