Modified (A)dS Schwarzschild black holes in Rainbow spacetime

A modified (Anti-)de Sitter Schwarzschild black hole solution is presented in the framework of rainbow gravity with a cosmological constant. Its thermodynamical properties are investigated. In general the temperature of modified black holes is dependent on the energy of probes which take the measurement. However, a notion of intrinsic temperature can be introduced by identifying these probes with radiation particles emitted from black holes. It is interesting to find that the Hawking temperature of this sort of black holes can be reproduced by employing the extended uncertainty principle and modified dispersion relations to the ordinary (A)dS Schwarzschild black holes.Comment: 11 pages. The version to appear in CQ

Coverage Optimization Strategy for WSN based on Energy-aware

In order to optimize the wireless sensor network coverage, this paper designs a coverage optimization strategy for wireless sensor network (EACS) based on energy-aware. Under the assumption that the geographic positions of sensor nodes are available, the proposed strategy consists of energy-aware and network coverage adjustment. It is restricted to conditions such as path loss, residual capacity and monitored area and according to awareness ability of sensors, it would adjust the monitored area, repair network hole and kick out the redundant coverage. The purpose is to balance the energy distribution of working nodes, reduce the number of “dead” nodes and balance network energy consumption. As a result, the network lifetime is expanded. Simulation results show that: EACS effectively reduces the number of working nodes, improves network coverage, lowers network energy consumption while ensuring the wireless sensor network coverage and connectivity, so as to balance network energy consumption

Modified dispersion relations and (A)dS Schwarzschild black holes

AbstractIn this Letter we investigate the impact of modified dispersion relations (MDR) on (Anti)de Sitter–Schwarzschild black holes. In this context we find the temperature of black holes can be derived with important corrections. In particular given a specific MDR the temperature has a maximal value such that it can prevent black holes from total evaporation. The entropy of the (A)dS black holes is also obtained with a logarithmic correction

Prospective study of efficacy and safety of non-ablative 1927 nm fractional thulium fiber laser in Asian skin photoaging

Background and ObjectivePhotoaging manifests as deeper wrinkles and larger pores. It has been tried to rejuvenate photoaging skin using a variety of lasers, including fractionated lasers, which are a popular photorejuvenation treatment. A new breakthrough for skin rejuvenation is the 1927 nm fractional thulium fiber laser (FTL), a laser and light-based treatment option. Clinical data regarding the FTL for treating photoaging are limited despite its effectiveness and safety. This study is aim to evaluate FTL' clinical effectiveness and safety.MethodsFitzpatrick skin types II–IV subjects with mild to moderate photoaging signs were enrolled in this prospective study. At intervals of one month, patients received three full face treatments. Wrinkles, spots, texture, pores, melanin index, erythema index (MI and EI), skin elasticity and hydration were measured with non-invasive tool. The epidermal thickness and dermal density on ultrasonography were compared between baseline and one month after all treatment sessions. The Global Score for Photoaging scale (GSP) was rated by two independent evaluators at the baseline and final follow-up visit. Secondary outcomes included patient-rated pain on a 10-point visual analog scale (VAS), as well as overall satisfaction. Following each treatment, adverse events were noted.ResultsTotally 27 subjects (24 females and 3 males) with Fitzpatrick skin types II to IV and a mean age of 44.41 (range33–64) were enrolled. Results suggests that the epidermal thickness has significantly improved after treatment. Statistically significant improvements in melanin index, skin elasticity and wrinkles were noted. An analysis of 12 subjects' reports (44%) suggested their skin felt brighter. No post-inflammatory hyperpigmentation changes or adverse events were observed. 70% patients reporting “satisfied” or “extremely satisfied”.ConclusionsIn this study, FTL was found to be a safe and effective treatment option for treating photoaging.</jats:sec

R ⁹³ P Substitution in the PmrB HAMP Domain Contributes to Colistin Heteroresistance in Escherichia coli Isolates from Swine

Here, the mechanisms of colistin heteroresistance (CHR) were assessed in 12 Escherichia coli isolates from swine in China. CHR was investigated by population analysis profile tests. CHR stability was studied by culturing isolates for five overnight incubation periods in colistin-free medium. Subsequently, the mcr-1 gene and mutations in PmrAB, PhoPQ, and MgrB were screened in parental isolates and resistant subpopulations. Additionally, the expression levels of phoPQ , its target gene pagP , and its negative regulator gene mgrB , as well as pmrAB and its target genes pmrHFIJKLM and pmrC , were determined by real-time relative quantitative PCR. </jats:p

Insight into the Double-Edged Role of Ferroptosis in Disease

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis

The role of C-reactive protein and genetic predisposition in the risk of psoriasis: results from a national prospective cohort

Abstract Background Psoriasis is an immune-mediated chronic inflammatory disease associated with multiple factors. To evaluate the extent to which C-reactive protein (CRP) and genetic predisposition affect the incidence of psoriasis. Methods The cohort study retrieved 420,040 participants without psoriasis at baseline from the UK Biobank. Serum CRP was categorized into two levels: < 2 mg/L (normal) and ≥ 2 mg/L (elevated). The polygenic risk score (PRS) was used to estimate genetic predisposition, and was characterized as low, moderate and high PRS. The possible interaction and joint associations between CRP and PRS were assessed using Cox proportional hazards models. Results Participants with high CRP levels had an increased risk of incident psoriasis compared to those with low CRP levels (HR: 1.26, 95% CI: 1.18–1.34). Participants with high CRP levels and high PRS had the highest risk of incident psoriasis [2.24 (95% CI: 2.01, 2.49)], compared with those had low CRP levels and low PRS. Significant additive and multiplicative interaction were found between CRP and PRS in relation to the incidence of psoriasis. Conclusions Our results suggest that higher CRP concentration may be associated with higher psoriasis incidence, with a more pronounced association observed in individuals with high PRS for psoriasis. So, clinicians should be aware that the risk of incident psoriasis may increase in general population with high CRP levels and high PRS, so that early investigation and intervention can be initiated

Insight into the Double-Edged Role of Ferroptosis in Disease

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson’s disease, and Alzheimer’s disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.</jats:p

Redefining surgical boundaries: outcomes of minimally invasive adrenalectomy in large pheochromocytomas

Background The safety and efficacy of minimally invasive adrenalectomy (MIA) for large pheochromocytoma (PHEO) remains a hotly debated topic. This study aims to shed light on the feasibility and safety of MIA for PHEOs > 5 cm.Materials and Methods We conducted a comprehensive retrospective analysis of 135 patients who underwent MIA for PHEOs at our centre from January 2016 to February 2023. After propensity score-matching (PSM) to balance baseline variables, 91 patients with tumours ≤ 5 cm and 44 patients with tumours > 5 cm were grouped into 33 pairs. Patient demographics and perioperative data were meticulously recorded and compared.Results After PSM, 33 pairs of patients were included (the larger group: 13 males, 20 females; mean age 50.0 ± 14.8 years; the smaller group: 12 males, 21 females; mean age 53.7 ± 11.8 years). There was no significant difference in baseline characteristics between the two groups except for tumour size (6.4 vs. 3.4 cm, p  5 cm had longer operative time and drainage tube removal time, it did not affect intraoperative hemodynamic outcomes and perioperative complications. Thus, minimally invasive adrenalectomy represents a viable and effective surgical option for managing large PHEO