Discoid lupus erythematosus and cutaneous squamous cell carcinoma

Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder characterized by inflammatory skin lesions. Patients with DLE often exhibit photosensitivity, scarring, and a higher susceptibility to skin cancers. This systematic review aims to comprehensively evaluate the existing literature to better understand the relationship between DLE and cutaneous squamous cell carcinoma (cSCC). A systematic search of major medical databases was conducted to identify relevant studies published between 1978 and 2023. Studies were included if they explored the association between DLE and cSCC and reported epidemiological data, clinical features and outcomes. Evidence shows a correlation between DLE and squamous cell carcinoma. The study aimed to find literature about DLE and squamous cell carcinoma (SCC) and analyse potential risk factors. Healthcare providers should be aware of the increased cancer risk in DLE patients, emphasizing the importance of regular skin examinations and sun protection

Determinants of environmental domain of quality of life in economically active population living in Silesian agglomeration, Poland

Objectives: The aim of this paper is to identify the factors that determine the environmental domain of quality of life in economically active adults living in the industrial agglomeration in Poland. Materials and Methods: During the crosssectional epidemiological study conducted among the economically active population aged 45–60, we used a short version of the WHOQOL-BREF questionnaire. Respondents were recruited randomly from selected factories located in the Silesian Agglomeration. The statistical analysis used descriptive and analytical methods available in the Statistica 9.0 software. Results: The results confi rmed the statistically signifi cant association between marital status, type of occupational activity, declared health status, and the environmental domain of quality of life in economically active inhabitants of the Silesian Agglomeration. The best qualities of life in the environmental domain were those of married people, white collars, and persons who declared their health status to be the best. Conclusions: The major determinants of environmental quality of life in economically active population living in the industrial agglomeration include non-occupational factors, such as marital status and current health status, while a signifi cantly better quality of life was associated with being a white-collar worker and not living in the vicinity of the road with heavy traffi c. The results may be useful for future planned activities intended to improve the health and the quality of working life

Pathologies of the skin and its appendages in endocrine diseases Patologie skóry i jej przydatków w schorzeniach endokrynologicznych

AbstrAct Patients suffering from endocrine disorders often present a wide profile of skin lesions. In hyperthyroidism we observe hair loss, lower leg myxedema and onycholysis or, in the case of hormone deficiency, generalized swelling of the skin, which becomes cold and pale. Primary hyperparathyroidism is revealed by pruritus, presence of chronic urticaria or deposition of amorphous calcium salts. In hypoparathyroidism, the skin is dry while the nails become very brittle. Skin lesions in diabetes include necrobiosis lipoidica, granuloma annulare, scleroderma-like diabetic edema and acanthosis nigricans. Overactive pituitary gland is often manifested as acromegaly with hypertrophy of soft tissue thickening and hypertrichosis. The skin in the early stages of hypopituitarism feels swollen, is pale yellow and oily, and finally becomes alabaster and dry. The characteristic features of Cushing syndrome are central obesity, lunar face, buffalo hump, and striae. In Addison's disease we observe hyperpigmentation. Hyperandrogenism in women leads to acne, hirsutism and virilization. streszczenie Zaburzeniom endokrynologicznym często towarzyszy szeroki zakres zmian skórnych. W nadczynności tarczycy obserwujemy utratę wło-sów, obrzęk przedgoleniowy i odwarstwienie płytki paznokciowej lub -jak w przypadku niedoboru hormonów -uogólniony obrzęk śluzo-waty skóry, która staje się zimna i blada. Pierwotna nadczynność przytarczyc objawia się świądem, obecnością przewlekłej pokrzywki lub odkładaniem bezpostaciowych soli wapnia. W niedoczynności przytarczyc skóra jest sucha, natomiast paznokcie są bardzo kruche. Zmiany skórne w cukrzycy obejmują między innymi obumieranie tłuszczowate, ziarniniaka obrączkowatego, obrzęk cukrzycowy twardzinopodobny oraz rogowacenie ciemne. Nadczynność przysadki często objawia się jako akromegalia z przerostem tkanek miękkich, pogrubieniem rysów twarzy oraz nadmiernym owłosieniem. Skóra w początkowym okresie niedoczynności przysadki sprawia wrażenie obrzękniętej, jest bladożółta i tłusta, a w miarę progresji zaburzeń staje się alabastrowa i sucha. Charakterystyczne cechy zespołu Cushinga to centralna otyłość, księżycowata twarz, bawoli kark oraz rozstępy. W chorobie Addisona obserwujemy przebarwienia. Hiperandrogenizm u kobiet powoduje trądzik, hirsutyzm oraz wirylizację

Lymphomatoid papulosis w populacji pediatrycznej – opis przypadku i rozważania terapeutyczne

Lymphomatoid papulosis (LyP) is a rare cutaneous disorder, most commonly observed in adults, and its occurrence in the pediatric population is exceedingly rare. We present the case of an 6-year-old male patient who exhibited clinical and histopathological features consistent with LyP. The patient presented with multiple erythematous papules on the trunk and extremities, which were accompanied by mild pruritus. The lesions intermittently appeared, disappeared, and changed in morphology. No lymphadenopathy or systemic symptoms were noted. The histopathological examination revealed a dense infiltrate of atypical lymphocytes with cerebriform nuclei in the dermis. Immunohistochemical analysis confirmed CD30 expression in the infiltrating cells, supporting the diagnosis of LyP. Topical corticosteroids were administered to alleviate pruritus and inflammation, although only minimal symptomatic relief was achieved. The beneficial effects of narrowband ultraviolet B (UVB) 311 phototherapy were observed for a duration of four months. Nevertheless, following the cessation of treatment, the reappearance of both the nodular lesions and smaller papular lesions was observed. Consequently, a therapeutic regimen consisting of the administration of methotrexate at a dosage of 10 mg once per week was initiated. The treatment of LyP varies depending on the severity of the lesions and the patient’s symptoms, treatment decisions need to be carefully weighed due to the relatively benign nature of the disease. The diagnosis of LyP in pediatric patients is challenging because of its rarity and potential confusion with malignant lymphomas. Histopathology and immunohistochemistry play a pivotal role in distinguishing LyP from more aggressive entities.Lymphomatoid papulosis (LyP) jest rzadką chorobą skóry, najczęściej obserwowaną u dorosłych, a jej występowanie w populacji pediatrycznej jest niezwykle rzadkie. W pracy przedstawiono przypadek 6-letniego dziecka płci męskiej, u którego stwierdzono cechy kliniczne i histopatologiczne zgodne z rozpoznaniem LyP. Na skórze pacjenta obserwowano liczne rumieniowe grudki zlokalizowane na tułowiu i kończynach, a towarzyszył im łagodny świąd. Zmiany chorobowe pojawiały się nawrotowo, następnie ustępowały i zmieniały morfologię. W badaniu przedmiotowym nie stwierdzono limfadenopatii ani objawów ogólnoustrojowych. W badaniu histopatologicznym w skórze właściwej stwierdzono gęsty naciek limfocytów atypowych z hiperchromatycznymi i nieregularnymi jądrami komórkowymi. Analiza immunohistochemiczna potwierdziła ekspresję CD30 w naciekających komórkach, co potwierdza rozpoznanie LyP. W celu złagodzenia świądu i stanu zapalnego podawano miejscowo glikokortykosteroidy, chociaż uzyskano jedynie minimalne złagodzenie objawów. Korzystne efekty fototerapii wąskopasmowej UVB 311 obserwowano przez cztery miesiące. Niemniej jednak po zaprzestaniu leczenia zaobserwowano ponowne pojawienie się zarówno zmian guzkowych, jak i mniejszych zmian grudkowych. W związku z tym rozpoczęto schemat terapeutyczny polegający na podawaniu metotreksatu w dawce 10 mg raz na tydzień. Leczenie LyP różni się zależnie od ciężkości zmian i objawów u pacjenta. Decyzje dotyczące leczenia należy dokładnie rozważyć ze względu na stosunkowo łagodny charakter choroby. Rozpoznanie LyP u dzieci i młodzieży stanowi wyzwanie ze względu na rzadkość występowania choroby i możliwość błędnego rozpoznania tej jednostki chorobowej z chłoniakami złośliwymi. Histopatologia i immunohistochemia odgrywają kluczową rolę w odróżnianiu LyP od bardziej agresywnych jednostek chorobowych

Pathologies of the skin and its appendages in endocrine diseases

Patients suffering from endocrine disorders often present a wide profile of skin lesions. In hyperthyroidism we observe hair loss, lower leg myxedema and onycholysis or, in the case of hormone deficiency, generalized swelling of the skin, which becomes cold and pale. Primary hyperparathyroidism is revealed by pruritus, presence of chronic urticaria or deposition of amorphous calcium salts. In hypoparathyroidism, the skin is dry while the nails become very brittle. Skin lesions in diabetes include necrobiosis lipoidica, granuloma annulare, scleroderma-like diabetic edema and acanthosis nigricans. Overactive pituitary gland is often manifested as acromegaly with hypertrophy of soft tissue thickening and hypertrichosis. The skin in the early stages of hypopituitarism feels swollen, is pale yellow and oily, and finally becomes alabaster and dry. The characteristic features of Cushing syndrome are central obesity, lunar face, buffalo hump, and striae. In Addison’s disease we observe hyperpigmentation. Hyperandrogenism in women leads to acne, hirsutism and virilization

Cicatricial alopecia: What’s new in etiology?

Cicatricial alopecia is a rare, clinically diversified set of disorders causing permanent and irreversible hair loss, which often results in serious discomfort and patient’s mental problems. Clinically, this form of irreversible hair loss is characterized by visible loss of hair follicle openings in the bald spots. Histologically, it consists in destroying a hair follicle and replacing it with fibrocartilage. Such disorders are perceived as primary if a hair follicle itself is the target of the disease process and secondary if hair follicles are damaged incidentally in the context of more general tissue damage (e.g. deep skin infections, thermal burns, trauma or ionizing radiation). In this article we tried to summarize the knowledge on possible pathogenic mechanisms of cicatricial alopecia. The presented factors usually overlap and affect prognosis of particular patients. Their profound understanding may enable further research on the treatment methods of this challenging disease unit