552 research outputs found

    Концепция соотношения сознательного и стихийного В.И. Ленина: опыт оценки

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    В статье представлен опыт оценки концепции соотношения сознательного и стихийного В.И. Ленина. Его структуру определяет последовательность решения задач, которая обеспечивает установление достижений и недостатков концепции соотношения сознательного и стихийного В.И.Ленина в истолковании этого соотношения. Сначала выделяются компоненты, образующие структуру теории соотношения сознательного и стихийного; затем выясняется, каким образом они раскрываются в концепции В.И. Ленина; после этого указываются критерии, по которым могут оцениваться философские концепции, определенным образом истолковывающие соотношение сознательного и стихийного; в соответствии с установленными критериями дается оценка как концепции соотношения сознательного и стихийного В.И. Ленина в целом, так и ее отдельным компонентам. В заключение делаются выводы о тех отношениях, в которых рассмотренная концепция В.И. Ленина может быть оценена позитивно и негативно.In the article the experience of estimation of conception of the alignment of conscious and elemental of V.I. Lenin is presented. Experience's structure is determined by the sequence of decision of tasks, which provides establishment of the achievements and lacks of the conception of the alignment of conscious and elemental of V.I. Lenin in the interpretation of this alignment. The components which form the structure of the theory of alignment of conscious and elemental are designated at first; then it appears, how they are being revealed in V.I. Lenin's conception; after this the criteria on which philosophical conceptions can be estimated are indicated, definitely interpreting the alignment of conscious and elemental; in accordance with the established criteria the estimation is given both of conception of alignment conscious and elemental of V.I. Lenin as a whole, and of its separate components. Inferences about those relations in which the considered conception of V.I. Lenin can be appraised positively and negatively are drawn in conclusion

    Directional Drilling and Stimulation of a Deep Sedimentary Geothermal Reservoir

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    geologische und energietechnische Ansatzpunkte

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    CSA-Induced PRES after Heart Transplantation-Report of Two Cases and Review

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    Background  Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disease possibly associated with the use of calcineurin inhibitors (CNI) like cyclosporine A. Case Description  The case of a patient who developed severe PRES under CNI therapy shortly after heart transplantation is presented here. Cerebral computed tomography led to the diagnose of PRES in our patient. New therapy strategy with a quadruple immunosuppressive protocol (cortisone, mycophenolate mofetil, low-dose CNI, and a mechanistic target of rapamycin inhibitor) was started. Conclusion  Under the quadruple therapy, a neurologic recovery occurred. In PRES, the presented alternative therapy strategy may lead to improving neurological conditions and preserved transplant organ functions

    Successful interdisciplinary treatment of a rare cause of acute myocardial ischaemia from intermittent tumour-associated obstruction of the left main coronary artery: a case report

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    Background A papillary fibroelastoma of the aortic valve has been reported as a rare cause of myocardial ischaemia. An advanced combined interventional and surgical approach leading to sufficient therapy for the patient is presented in this case report. Case summary A 56-year-old female patient presented in an emergency room of a hospital with an acute coronary syndrome. Over 1.5 years, recurrent stable angina had been known in the patient and significant coronary artery disease has already been ruled out in a previous coronary angiogram. The patient was immediately transferred to the catheter laboratory due to cardiogenic shock where a drug-eluting stent was implanted to, firstly, recanalize the left main coronary artery (LMCA) and, secondly, to protect the left main ostium from obstruction by an echocardiographic-proven mass. During subsequent deterioration of haemodynamics caused by decreasing left ventricular function and acute severe mitral insufficiency, firstly an intra-aortic balloon pump and secondly a veno-arterial extracorporeal membrane oxygenation was established through the femoral vessels. The patient was transferred to our cardiac surgery unit and was successfully operated utilizing a valve-sparing technique by extracting the tumour mass from the left coronary cusp and extracting the stent carefully from the LMCA. Histology revealed a papillary fibroelastoma. Conclusion A papillary fibroelastoma of the aortic valve with intermittent obstruction of the coronary arteries requires surgical therapy. Interventional recanalization and extracorporeal support might be useful strategies to ensure the patient's safety as a bridge to surgery

    Cloud Computing in Healthcare – a Literature Review on Current State of Research

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    Nowadays, IT resources are increasingly being used in all areas of the health sector. Cloud computing offers a promising approach to satisfy the IT needs in a favorable way. Despite numerous publications in the context of cloud computing in healthcare, there is no systematic review on current research so far. This paper addresses the gap and is aimed to identify the state of research and determine the potential areas of future research in the domain. We conduct a structured literature search based on an established framework. Through clustering of the research goals of the found papers we derive research topics including developing cloud-based applications, platforms or brokers, security and privacy mechanisms, and benefit assessments for the use of cloud computing in healthcare. We hence analyze current research results across the topics and deduce areas for future research, e.g., development, validation and improvement of proposed solutions, an evaluation framework

    Fluid release from the subducted Cocos plate and partial melting of the crust deduced from magnetotelluric studies in southern Mexico: implications for the generation of volcanism and subduction dynamics

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    In order to study electrical conductivity phenomena that are associated with subduction related fluid release and melt production, magnetotelluric (MT) measurements were carried out in southern Mexico along two coast to coast profiles. The conductivity-depth distribution was obtained by simultaneous two-dimensional inversion of the transverse magnetic and transverse electric modes of the magnetotelluric transfer functions. The MT models demonstrate that the plate southern profile shows enhanced conductivity in the deep crust. The northern profile is dominated by an elongated conductive zone extending >250 km below the Trans-Mexican Volcanic Belt (TMVB). The isolated conductivity anomalies in the southern profile are interpreted as slab fluids stored in the overlying deep continental crust. These fluids were released by progressive metamorphic dehydration of the basaltic oceanic crust. The conductivity anomalies may be related to the main dehydration reactions at the zeolite → blueschist → eclogite facies transitions and the breakdown of chlorite. This relation allows the estimation of a geothermal gradient of ∼8.5°C/km for the top of the subducting plate. The same dehydration reactions may be recognized along the northern profile at the same position relative to the depth of the plate, but more inland due to a shallower dip, and merge near the volcanic front due to steep downbending of the plate. When the oceanic crust reaches a depth of 80–90 km, ascending fluids produce basaltic melts in the intervening hot subcontinental mantle wedge that give rise to the volcanic belt. Water-rich basalts may intrude into the lower continental crust leading to partial melting. The elongated highly conductive zone below the TMVB may therefore be caused by partial melts and fluids of various origins, ongoing migmatization, ascending basaltic and granitic melts, growing plutons as well as residual metamorphic fluids. Zones of extremely high conductance (>8000 S) in the continental crust on either MT profile might indicate extinct magmatism

    Case report—CARMAT: the first experience with the Aeson bioprosthetic total artificial heart as a bridge to transplantation in a case of post-infarction ventricular septal rupture

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    BackgroundPost-infarction ventricular septal defects remain one of the most feared complications after myocardial infarction with high mortality rates. In special cases, surgical or interventional treatment strategies are technically not feasible and do not always lead to a good outcome.Case presentationA 58-year-old male patient in cardiogenic shock with a very large ventricular septal (VSD) defect (4.9 cm × 5 cm) due to myocardial infarction was presented in our department. Acute stabilization was achieved using peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. Neither surgical nor interventional therapy was considered as a sufficient option due to the unsuitable anatomy of the VSD and the patient was listed for heart transplantation. After 2 weeks on ECMO, bleeding and infectious complications occurred. Due to organ shortage, urgent implantation of the bioprosthetic total artificial heart (TAH) Aeson device (CARMAT) remained the only useful strategy to achieve a mid- or long-term bridge to transplantation. After successful implantation and good recovery with the Aeson device, the patient was transplanted 4 weeks after implantation.ConclusionPost-infarction ventricular septal defects are highly challenging and are commonly associated with a poor prognosis. The implantation of the new Aeson TAH device is a promising therapeutic option, allowing a safe and long-term bridging to heart transplantation
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