Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats

Abstract Background Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. Methods The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively. Results Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Conclusions These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis. </jats:sec

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Genes that showed greater than four-fold upregulation in IBD. (XLSX 28 kb

Critical Role of AKT in Myeloma-induced Osteoclast Formation and Osteolysis

Abnormal osteoclast formation and osteolysis are the hallmarks of multiple myeloma (MM) bone disease, yet the underlying molecular mechanisms are incompletely understood. Here, we show that the AKT pathway was up-regulated in primary bone marrow monocytes (BMM) from patients with MM, which resulted in sustained high expression of the receptor activator of NF-κB (RANK) in osteoclast precursors. The up-regulation of RANK expression and osteoclast formation in the MM BMM cultures was blocked by AKT inhibition. Conditioned media from MM cell cultures activated AKT and increased RANK expression and osteoclast formation in BMM cultures. Inhibiting AKT in cultured MM cells decreased their growth and ability to promote osteoclast formation. Of clinical significance, systemic administration of the AKT inhibitor LY294002 blocked the formation of tumor tissues in the bone marrow cavity and essentially abolished the MM-induced osteoclast formation and osteolysis in SCID mice. The level of activating transcription factor 4 (ATF4) protein was up-regulated in the BMM cultures from multiple myeloma patients. Adenoviral overexpression of ATF4 activated RANK expression in osteoclast precursors. These results demonstrate a new role of AKT in the MM promotion of osteoclast formation and bone osteolysis through, at least in part, the ATF4-dependent up-regulation of RANK expression in osteoclast precursors

Flag-transitive automorphism groups of 22-designs with λ≥(r,λ)2\lambda\geq (r,\lambda)^2 are not product type

In this paper we show that a flag-transitive automorphism group $G$ of a non-trivial $2$-$(v,k,\lambda)$ design with $\lambda\geq (r, \lambda)^2$ is not of product action type. In conclusion, $G$ is a primitive group of affine or almost simple type.Comment: 13 pages,2 figure

Method of Time Series Similarity Measurement Based on Dynamic Time Warping

With the rapid development of mobile communication all over the world, the similarity of mobile phone communication data has received widely attention due to its advantage for the construction of smart cities. Mobile phone communication data can be regarded as a type of time series and dynamic time warping (DTW) and derivative dynamic time warping (DDTW) are usually used to analyze the similarity of these data. However, many traditional methods only calculate the distance between time series while neglecting the shape characteristics of time series. In this paper, a novel hybrid method based on the combination of dynamic time warping and derivative dynamic time warping is proposed. The new method considers not only the distance between time series, but also the shape characteristics of time series. We demonstrated that our method can outperform DTW and DDTW through extensive experiments with respect to cophenetic correlation

Towards a muon scattering tomography system for both low-Z and high-Z materials

Muon scattering tomography (MST) is a non-destructive technique to image various materials by utilizing cosmic ray muons as probes. A typical MST system with a two-fold track detectors is particularly effective in detecting high-$Z$ materials (e.g. nuclear materials), but difficult to recognize low-$Z$ materials (e.g. explosive materials). In this work, we present a concept of MST system to discriminate both low-$Z$ and high-$Z$ materials by extra measuring momentum of low-energy muons with a Cherenkov detector. A toy Monte Carlo simulation to describe detector responses and multiple scatterings of a muon tracking through materials is developed for statistical tests. Based on momentum-dependent track reconstruction and image reconstruction algorithm, we evaluate separation powers of different materials in the system. The results show that momentum measurement of low-energy muons and accurate track reconstruction can improve separation power of low-$Z$ materials significantly. This may enable the MST system to detect both low-$Z$ and high-$Z$ materials with cosmic ray muons in the whole energy range.Comment: 17 pages with 13 figures and 1 tabl

Access, Oppression, and Social (In)Justice in Epidemic Control: Race, Profession, and Communication in SARS Outbreaks in Canada and Singapore

This article investigates issues of social injustice experienced by various oppressed groups in SARS outbreaks in 2003, paying particular attention to medical care workers in Canada and Singapore, with many of them being immigrants from East Asia and Southeast Asia. It identifies communication strategies employed by civic networks, especially nonprofit organizations, to help marginalized groups acquire institutional and literacy accesses so that they could respond more effectively to such injustices in complicated and multicultural contexts. Through combined use of Jost and Kay’s work on the three types of social justice (2010), oppression (Young, 1990), and access (Porter, 1998), this study produces rich and multifaceted insights about issues of social injustice in SARS outbreaks. More importantly, it elaborates on the theoretical connections among the three social justice theories and shows possible entry points, particularly the conjunction between process control and informational justice, for professional communicators to produce constructive responses to social injustices and to promote social justice and access for marginalized groups

Analysis of medicine consumption in peacekeeping level II hospitals

Background: The peacekeeping military units of contributing countries are unfamiliar with the conditions prevailing in foreign mission areas and therefore have difficulties with medical supplies storage.Aim: The aim of this study is to provide reasonable and practical guidance on the maintenance of medical supplies in the peacekeeping military units of contributing countries.Materials and methods: A total of 1,972 prescriptions were received by the pharmacy in the peacekeeping level II hospital in the Republic of Sudan from February to July of 2009 including a total of 186 drug categories and 17,713 minimum packing units. Pairwise comparison was performed using the c2 test. When thetotal number of samples was smaller than 40, the Fisher’s exact test was adopted for pairwise comparison.Results: The majority of the consumed medicines mainly belonged to 6 categories, including specialty drugs, anti-microbial drugs, Chinese patent medicines, gastrointestinal drugs, central nervous system drugs, and drugs regulating fluids, electrolytes, and acid-base balance. Altogether, the drugs in the 6 categories accounted for 74% of all consumed medicines that were divided into a total of 20 categories.Conclusions: Medicine consumption in peacekeeping level II hospitals is unique, therefore the drugs used in military medical facilities should be prepared according to their actual needs in the area of peacekeeping operations