A Cosmic Microwave Background Radiation Polarimeter Using Superconducting Bearings

Measurements of the polarization of the cosmic microwave background (CMB) radiation are expected to significantly increase our understanding of the early universe. We present a design for a CMB polarimeter in which a cryogenically cooled half wave plate rotates by means of a high-temperature superconducting (HTS) bearing. The design is optimized for implementation in MAXIPOL, a balloon-borne CMB polarimeter. A prototype bearing, consisting of commercially available ring-shaped permanent magnet and an array of YBCO bulk HTS material, has been constructed. We measured the coefficient of friction as a function of several parameters including temperature between 15 and 80 K, rotation frequency between 0.3 and 3.5 Hz, levitation distance between 6 and 10 mm, and ambient pressure between 10^{-7} and 1 torr. The low rotational drag of the HTS bearing allows rotations for long periods of time with minimal input power and negligible wear and tear thus making this technology suitable for a future satellite mission.Comment: 6 pages, IEEE-Transactions of Applied Superconductivity, 2003, Vol. 13, in pres

Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?

AIM: To determine whether aspirin or non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAIDs) prevent colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD). METHODS: We performed a systematic review and meta-analysis. We searched for articles reporting the risk of CRC in patients with IBD related to aspirin or NA-NSAID use. Pooled odds ratios (OR) and 95%CIs were determined using a random-effects model. Publication bias was assessed using Funnel plots and Egger’s test. Heterogeneity was assessed using Cochran’s Q and the I2 statistic. RESULTS: Eight studies involving 14917 patients and 3 studies involving 1282 patients provided data on the risk of CRC in patients with IBD taking NA-NSAIDs and aspirin respectively. The pooled OR of developing CRC after exposure to NA-NSAIDs in patients with IBD was 0.80 (95%CI: 0.39-1.21) and after exposure to aspirin it was 0.66 (95%CI: 0.06-1.39). There was significant heterogeneity (I2 > 50%) between the studies. There was no change in the effect estimates on subgroup analyses of the population studied or whether adjustment or matching was performed. CONCLUSION: There is a lack of high quality evidence on this important clinical topic. From the available evidence NA-NSAID or aspirin use does not appear to be chemopreventative for CRC in patients with IBD

Explicit solution for vibrating bar with viscous boundaries and internal damper

We investigate longitudinal vibrations of a bar subjected to viscous boundary conditions at each end, and an internal damper at an arbitrary point along the bar's length. The system is described by four independent parameters and exhibits a variety of behaviors including rigid motion, super stability/instability and zero damping. The solution is obtained by applying the Laplace transform to the equation of motion and computing the Green's function of the transformed problem. This leads to an unconventional eigenvalue-like problem with the spectral variable in the boundary conditions. The eigenmodes of the problem are necessarily complex-valued and are not orthogonal in the usual inner product. Nonetheless, in generic cases we obtain an explicit eigenmode expansion for the response of the bar to initial conditions and external force. For some special values of parameters the system of eigenmodes may become incomplete, or no non-trivial eigenmodes may exist at all. We thoroughly analyze physical and mathematical reasons for this behavior and explicitly identify the corresponding parameter values. In particular, when no eigenmodes exist, we obtain closed form solutions. Theoretical analysis is complemented by numerical simulations, and analytic solutions are compared to computations using finite elements.Comment: 29 pages, 6 figure

Super-Yang-Mills and M5-branes

We uplift 5-dimensional super-Yang-Mills theory to a 6-dimensional gauge theory with the help of a space-like constant vector $\eta^M$, whose norm determines the Yang-Mills coupling constant. After the localization of $\eta^M$ the 6D gauge theory acquires Lorentzian invariance as well as scale invariance. We discuss KK states, instantons and the flux quantization. The 6D theory admits extended solutions like 1/2 BPS `strings' and monopoles.Comment: 15 pages; minor changes, to appear in JHE

Parent formulation at the Lagrangian level

The recently proposed first-order parent formalism at the level of equations of motion is specialized to the case of Lagrangian systems. It is shown that for diffeomorphism-invariant theories the parent formulation takes the form of an AKSZ-type sigma model. The proposed formulation can be also seen as a Lagrangian version of the BV-BRST extension of the Vasiliev unfolded approach. We also discuss its possible interpretation as a multidimensional generalization of the Hamiltonian BFV--BRST formalism. The general construction is illustrated by examples of (parametrized) mechanics, relativistic particle, Yang--Mills theory, and gravity.Comment: 26 pages, discussion of the truncation extended, typos corrected, references adde

Are there biological differences between screen-detected and interval colorectal cancers in the English Bowel Cancer Screening Programme?

Background: We measured biomarkers of tumour growth and vascularity in interval and screen-detected colorectal cancers (CRCs) in the English Bowel Cancer Screening Programme in order to determine whether rapid tumour growth might contribute to interval CRC (a CRC diagnosed between a negative guaiac stool test and the next scheduled screening episode). Methods: Formalin-fixed, paraffin-embedded sections from 71 CRCs (screen-detected 43, interval 28) underwent immunohistochemistry for CD31 and Ki-67, in order to measure the microvessel density (MVD) and proliferation index (PI), respectively, as well as microsatellite instability (MSI) testing. Results: Interval CRCs were larger (P=0.02) and were more likely to exhibit venous invasion (P=0.005) than screen-detected tumours. There was no significant difference in MVD or PI between interval and screen-detected CRCs. More interval CRCs displayed MSI-high (14%) compared with screen-detected tumours (5%). A significantly (P=0.005) higher proportion (51%) of screen-detected CRC resection specimens contained at least one polyp compared with interval CRC (18%) resections. Conclusions: We found no evidence of biological differences between interval and screen-detected CRCs, consistent with the low sensitivity of guaiac stool testing as the main driver of interval CRC. The contribution of synchronous adenomas to occult blood loss for screening requires further investigation

Membrane Sigma-Models and Quantization of Non-Geometric Flux Backgrounds

We develop quantization techniques for describing the nonassociative geometry probed by closed strings in flat non-geometric R-flux backgrounds M. Starting from a suitable Courant sigma-model on an open membrane with target space M, regarded as a topological sector of closed string dynamics in R-space, we derive a twisted Poisson sigma-model on the boundary of the membrane whose target space is the cotangent bundle T^*M and whose quasi-Poisson structure coincides with those previously proposed. We argue that from the membrane perspective the path integral over multivalued closed string fields in Q-space is equivalent to integrating over open strings in R-space. The corresponding boundary correlation functions reproduce Kontsevich's deformation quantization formula for the twisted Poisson manifolds. For constant R-flux, we derive closed formulas for the corresponding nonassociative star product and its associator, and compare them with previous proposals for a 3-product of fields on R-space. We develop various versions of the Seiberg-Witten map which relate our nonassociative star products to associative ones and add fluctuations to the R-flux background. We show that the Kontsevich formula coincides with the star product obtained by quantizing the dual of a Lie 2-algebra via convolution in an integrating Lie 2-group associated to the T-dual doubled geometry, and hence clarify the relation to the twisted convolution products for topological nonassociative torus bundles. We further demonstrate how our approach leads to a consistent quantization of Nambu-Poisson 3-brackets.Comment: 52 pages; v2: references adde

Heterotic non-linear sigma models with anti-de Sitter target spaces

We calculate the beta function of non-linear sigma models with S^{D+1} and AdS_{D+1} target spaces in a 1/D expansion up to order 1/D^2 and to all orders in \alpha'. This beta function encodes partial information about the spacetime effective action for the heterotic string to all orders in \alpha'. We argue that a zero of the beta function, corresponding to a worldsheet CFT with AdS_{D+1} target space, arises from competition between the one-loop and higher-loop terms, similarly to the bosonic and supersymmetric cases studied previously in hep-th/0512355. Various critical exponents of the non-linear sigma model are calculated, and checks of the calculation are presented.Comment: 36 pages, 7 figure

Electroweak Symmetry Breaking in the DSSM

We study the theoretical and phenomenological consequences of modifying the Kahler potential of the MSSM two Higgs doublet sector. Such modifications naturally arise when the Higgs sector mixes with a quasi-hidden conformal sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field space due to the presence of quasi-hidden sector states which get their mass from the Higgs vevs. The presence of these extra states leads to the fact that even as Delta approaches 1, the DSSM does not reduce to the MSSM. In particular, the Higgs can naturally be heavier than the W- and Z-bosons. Perturbative gauge coupling unification, a large top quark Yukawa, and consistency with precision electroweak can all be maintained for Delta close to unity. Moreover, such values of Delta can naturally be obtained in string-motivated constructions. The quasi-hidden sector generically contains states charged under SU(5)_GUT as well as gauge singlets, leading to a rich, albeit model-dependent, collider phenomenology.Comment: v3: 40 pages, 3 figures, references added, typos correcte