ネットワーク符号化に基づく匿名P2PネットワークのChurnとTampering耐性

On an efficient and economic way to add churn- and tampering resilience to an existing anonymous peer-to-peer network using threshold secret sharing schemes and systematic Reed-Solomon code電気通信大学201

Evolución macroeconómica reciente de una economía: el caso de Grecia.

La casuística de la economía griega cobra cierta importancia a partir del estallido de la crisis económica, a raíz de los problemas financieros a los que el país se ha enfrentado durante la era post 2008, y más concretamente a causa de las reformas en materia de política económica que ha tenido que adoptar para beneficiarse de los rescates provenientes de la troika. Con una economía y estructura productiva características de los países del sur europeo, Grecia representa uno de los muchos ejemplos de la existencia de dos bloques económicos en la Unión Europea actual: los países del norte y centro de Europa, y los Estados del sur del continente. Entre ellos existen múltiples divergencias, las cuales se analizan en este trabajo fin de grado desde la perspectiva griega, y que explican en parte la trayectoria macroeconómica que ha seguido cada uno de ellos hasta la actualidad

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis

A key role of both coagulation and vascular thrombosis has been reported since the first descriptions of multiple sclerosis (MS). Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of clinical signs in experimental allergic encephalomyelitis (EAE), an animal model of MS, led to numerous investigations focused on the role of thrombin and fibrin(ogen). Indeed, the activation of microglia, resident innate immune cells, occurs early after fibrinogen leakage in the pre-demyelinating lesion stage of EAE and MS. Thrombin has both neuroprotective and pro-apoptotic effects according to its concentration. After exposure to high concentrations of thrombin, astrocytes become reactive and lose their neuroprotective and supportive functions, microglia proliferate, and produce reactive oxygen species, IL-1β, and TNFα. Heparin inhibits the thrombin generation and suppresses EAE. Platelets play an important role too. Indeed, in the acute phase of the disease, they begin the inflammatory response in the central nervous system by producing of IL-1alpha and triggering and amplifying the immune response. Their depletion, on the contrary, ameliorates the course of EAE. Finally, it has been proven that the use of several anticoagulant agents can successfully improve EAE. Altogether, these studies highlight the role of the coagulation pathway in the pathophysiology of MS and suggest possible therapeutic targets that may complement existing treatments