Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.

Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown. Using a combination of in vivo and in vitro experiments, we show that they regulate a stepwise assembly of the termination complex. Rli1 and eRF3-GDP associate with the ribosome first. Subsequently, Dbp5-ATP delivers eRF1 to the stop codon and in this way prevents a premature access of eRF3. Dbp5 dissociates upon placing eRF1 through ATP-hydrolysis. This in turn enables eRF1 to contact eRF3, as the binding of Dbp5 and eRF3 to eRF1 is mutually exclusive. Defects in the Dbp5-guided eRF1 delivery lead to premature contact and premature dissociation of eRF1 and eRF3 from the ribosome and to subsequent stop codon readthrough. Thus, the stepwise Dbp5-controlled termination complex assembly is essential for regular translation termination events. Our data furthermore suggest a possible role of Dbp5/DDX19 in alternative translation termination events, such as during stress response or in developmental processes, which classifies the helicase as a potential drug target for nonsense suppression therapy to treat cancer and neurodegenerative diseases

Comment on "Control landscapes are almost always trap free: a geometric assessment"

We analyze a recent claim that almost all closed, finite dimensional quantum systems have trap-free (i.e., free from local optima) landscapes (B. Russell et.al. J. Phys. A: Math. Theor. 50, 205302 (2017)). We point out several errors in the proof which compromise the authors' conclusion. Interested readers are highly encouraged to take a look at the "rebuttal" (see Ref. [1]) of this comment published by the authors of the criticized work. This "rebuttal" is a showcase of the way the erroneous and misleading statements under discussion will be wrapped up and injected in their future works, such as R. L. Kosut et.al, arXiv:1810.04362 [quant-ph] (2018).Comment: 6 pages, 1 figur

Frequency-dependent reflection of spin waves from a magnetic inhomogeneity induced by a surface DC-current

The reflectivity of a highly localized magnetic inhomogeneity is experimentally studied. The inhomogeneity is created by a dc-current carrying wire placed on the surface of a ferrite film. The reflection of propagating dipole-dominated spin-wave pulses is found to be strongly dependent on the spin-wave frequency if the current locally increases the magnetic field. In the opposite case the frequency dependence is negligible.Comment: 3 pages, 3 figure

Self Replication and Signalling

It is known that if one could clone an arbitrary quantum state one could send signal faster than the speed of light. However it remains interesting to see that if one can perfectly self replicate an arbitrary quantum state, does it violate the no signalling principle? Here we see that perfect self replication would also lead to superluminal signalling.Comment: Modified version of quant-ph/0510221, Accepted in International Journal of Theoretical Physic

Band Crossing and Novel Low-Energy Behaviour in a Mean Field Theory of a Three-Band Model on a Cu--O lattice

We study correlation effects in a three-band extended Hubbard model of Cu -- O planes within the 1/N mean field approach, in the infinite U limit. We investigate the emerging phase diagram and discuss the low energy scales associated with each region. With increasing direct overlap between oxygen orbitals, $t_{pp} >0$, the solution displays a band crossing which, for an extended range of parameters, lies close to the Fermi level. In turn this leads to the nearly nested character of the Fermi surface and the resulting linear temperature dependence of the quasi-particle relaxation rate for sufficiently large T. We also discuss the effect of band crossing on the optical conductivity and comment on the possible experimental relevance of our findings.Comment: 12 pages, Latex-Revtex, 6 PostScript figures. Submitted to Phys. Rev.

Field-induced transition from parallel to perpendicular parametric pumping for a microstrip transducer

Microstrip transducers used for the excitation of spin waves in magnetic films possess two characteristic properties: high spatial localization of the microwave magnetic field and the presence of field components parallel and perpendicular to the bias field. Here, the effects of these features on the process of parametric pumping are presented. By microwave measurements of the spin-wave instability threshold a transition from parallel pumping to perpendicular pumping at the critical field $H_{\rm c}$ with the minimal threshold is observed. This transition is accompanied by a sharp threshold increase above the critical field due to the spatial confinement of the pump region.Comment: 4 pages, 2 figure

Quantum strategies

We consider game theory from the perspective of quantum algorithms. Strategies in classical game theory are either pure (deterministic) or mixed (probabilistic). We introduce these basic ideas in the context of a simple example, closely related to the traditional Matching Pennies game. While not every two-person zero-sum finite game has an equilibrium in the set of pure strategies, von Neumann showed that there is always an equilibrium at which each player follows a mixed strategy. A mixed strategy deviating from the equilibrium strategy cannot increase a player's expected payoff. We show, however, that in our example a player who implements a quantum strategy can increase his expected payoff, and explain the relation to efficient quantum algorithms. We prove that in general a quantum strategy is always at least as good as a classical one, and furthermore that when both players use quantum strategies there need not be any equilibrium, but if both are allowed mixed quantum strategies there must be.Comment: 8 pages, plain TeX, 1 figur

Weak Value in Wave Function of Detector

A simple formula to read out the weak value from the wave function of the measuring device after the postselection with the initial Gaussian profile is proposed. We apply this formula for the weak value to the classical experiment of the realization of the weak measurement by the optical polarization and obtain the weak value for any pre- and post-selections. This formula automatically includes the interference effect which is necessary to yields the weak value as an outcome of the weak measurement.Comment: 3 pages, no figures, Published in Journal of the Physical Society of Japa

ROTATIONAL-DYNAMICS OF SOLID C-70 - A NEUTRON-SCATTERING STUDY

PMID: 10011126PMID: 10011126 This work at the University of Sussex at supported by the Science and Engineering Research Council, U.K.PMID: 10011126 This work at the University of Sussex at supported by the Science and Engineering Research Council, U.K.PMID: 10011126 This work at the University of Sussex at supported by the Science and Engineering Research Council, U.K.We report the results of neutron-diffraction and low-energy neutron-inelastic-scattering experiments on high-purity solid C-70 between 10 and 640 K. Thermal hysteresis effects are found to accompany structural changes both on cooling and on heating. The observed diffuse scattering intensity does not change with temperature. At 10 K broad librational peaks are observed at 1.82(16) meV [full width at half maximum=1.8(5) meV]. The peaks soften and broaden further with increasing temperature. At and above room temperature, they collapse into a single quasielastic line. At 300 K, the diffusive reorientational motion appears to be somewhat anisotropic, becoming less so with increasing temperature. An isotropic rotational diffusion model, in which the motions of adjacent molecules are uncorrelated, describes well the results at 525 K. The temperature dependence of the rotational diffusion constants is consistent with a thermally activated process having an activation energy of 32(7) meV.This work at the University of Sussex at supported by the Science and Engineering Research Council, U.K