Passion Berwirausaha pada Pengusaha Muda

This study aims to understand understanding the dynamics of passion in youth entrepreneurs when running a business. By understanding the dynamics of passion in running a business, youth entrepreneurs can understand the importance of passion\u27s role to his business so as to avoid failure. In order to achieve these objectives, a phenomenological study was conducted on purposively selected participants, ie nascentor new bussiness entrepreneurs who have passion in entrepreneurship aged 18 to 34years. Data were collected using semi-structured phenomenological interviews, and analyzed using a phenomenological analysis approach. The results show that the dynamics of passion play an important role in the three series of areas of entrepreneurial activity: 1) product creation and development, 2) business establishment, 3) business development. While also found the aspects of personal, environmental and behaviour that affect the emergence of entrepreneurial passion on them

Peran Job Insecurity terhadap Stres Kerja dengan Moderator Religiusitas

Stress is one of the psychological reactions that can be in a work situation. Work situations may change at any time in different forms. An employee\u27s psychological reaction to change also varies. Job insecurity arising from changing work situations increases job stress. A company certainly does not want employees to experience work stress that can impact on the decline in company performance. The level of employeereligiosity is expected to reduce the impact of job insecurity. This study aims to determine the role of job insecurity against work stress moderated by religiosity. Job stress as dependent variable, job insecurity as independent variable, and religiosity as moderator. Methods of data retrieval were performed using work stress scale, job insecurity scale, and scale of religiosity. The subjects of this study were 119 employees working in the State Forestry Corporation. The hypothesis proposed in this study is religiosity as a moderator in the relationship between job insecurity with work stress. Moderate and hypothesis testis done by moderate regression analysis. The research result shows religiosity not proved as moderator in relationship between job insecurity with work stress, but directly significant impact to work

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

\ua9 2023, Springer Nature Limited. The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Multi-ancestry genome-wide association meta-analysis of Parkinson's disease

Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson's disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations. Multi-ancestry genome-wide association analyses identify new risk loci for Parkinson's disease, and fine-mapping and co-localization analyses implicate candidate genes whose expression is associated with disease susceptibility