Dynamics of oculomotor direction discrimination

Successful foveation of a dynamic target depends on good predictions of its movement direction and speed. We measured and compared the temporal dynamics of directional precision of both saccades and smooth pursuit and their interactions. We also compared the directional precision of both eye movements to psychophysical direction discrimination thresholds. Directional thresholds of pure pursuit responses improved rapidly and reached asymptotic values of 1.5°–3° within 300 ms after target motion onset, both for trained and untrained observers and irrespective of the speed of the stimuli. Psychophysical thresholds were in the same range. Directional thresholds for saccades in the ramp paradigm were just slightly higher, but these occurred significantly earlier in time at around 200 ms after target motion onset. At the equivalent time during pure pursuit initiation, thresholds were typically higher by 2°–3°. The rise in directional precision—or decrease in thresholds—over time was more pronounced for trials with longer latencies. As an effect, precision depended mainly on time since stimulus motion onset rather than pursuit onset. Directional precision for saccades to static targets was slightly better than to moving targets, at even shorter latencies. We conclude that directional precision is higher for the saccadic system at saccade onset than for the pursuit system, presumably due to additional position signals that are not available to the pursuit system at that point in time. The pursuit response improves rapidly due to refined sensory processing and motor planning. The combination of initial saccades and pursuit to track moving targets is a good strategy for the oculomotor system to reduce directional errors during the phase of initiation. The target speed has very little effects on the directional precision of both eye movements

The WiggleZ Dark Energy Survey: Galaxy Evolution at 0.25 ≤ z ≤ 0.75 Using the Second Red-Sequence Cluster Survey

We study the evolution of galaxy populations around the spectroscopic WiggleZ sample of star-forming galaxies at 0.25 ≤ z ≤ 0.75 using the photometric catalog from the Second Red-Sequence Cluster Survey (RCS2). We probe the optical photometric properties of the net excess neighbor galaxies. The key concept is that the marker galaxies and their neighbors are located at the same redshift, providing a sample of galaxies representing a complete census of galaxies in the neighborhood of star-forming galaxies. The results are compared with those using the RCS WiggleZ Spare-Fibre (RCS-WSF) sample as markers, representing galaxies in cluster environments at 0.25 ≤ z ≤ 0.45. By analyzing the stacked color-color properties of the WiggleZ neighbor galaxies, we find that their optical colors are not a strong function of indicators of star-forming activities such as EW([O II]) or Galaxy Evolution Explorer (GALEX) near-UV luminosity of the markers. The galaxies around the WiggleZ markers exhibit a bimodal distribution on the color-magnitude diagram, with most of them located in the blue cloud. The optical galaxy luminosity functions (GLFs) of the blue neighbor galaxies have a faint-end slope α of ~ –1.3, similar to that for galaxies in cluster environments drawn from the RCS-WSF sample. The faint-end slope of the GLF for the red neighbors, however, is ~ –0.4, significantly shallower than the ~ –0.7 found for those in cluster environments. This suggests that the buildup of the faint end of the red sequence in cluster environments is in a significantly more advanced stage than that in the star-forming and lower galaxy density WiggleZ neighborhoods. We find that the red galaxy fraction (f_red) around the star-forming WiggleZ galaxies has similar values from z ~ 0.3 to z ~ 0.6 with f_red ~ 0.28, but drops to f_red ~ 0.20 at z gsim 0.7. This change of f_red with redshift suggests that there is either a higher rate of star-forming galaxies entering the luminosity-limited sample at z ≳ 0.7, or a decrease in the quenching rate of star formation at that redshift. Comparing to that in a dense cluster environment, the f_red of the WiggleZ neighbors is both considerably smaller and has a more moderate change with redshift, pointing to the stronger and more prevalent environmental influences on galaxy evolution in high-density regions

Uncoupled Phosphorylation and Activation in Bacterial Chemotaxis - The 2.3 Å structure of an aspartate to lysine mutant at position 13 of CheY

An aspartate to lysine mutation at position 13 of the chemotaxis regulatory protein CheY causes a constitutive tumbly phenotype when expressed at high copy number in vivo even though the mutant protein is not phosphorylatable. These properties suggest that the D13K mutant adopts the active, signaling conformation of CheY independent of phosphorylation, so knowledge of its structure could explain the activation mechanism of CheY. The x-ray crystallographic structure of the CheY D13K mutant has been solved and refined at 2.3 Å resolution to an R-factor of 14.3%. The mutant molecule shows no significant differences in backbone conformation when compared with the wild-type, Mg2+-free structure, but there are localized changes within the active site. The side chain of lysine 13 blocks access to the active site, whereas its epsilon -amino group has no bonding interactions with other groups in the region. Also in the active site, the bond between lysine 109 and aspartate 57 is weakened, and the solvent structure is perturbed. Although the D13K mutant has the inactive conformation in the crystalline form, rearrangements in the active site appear to weaken the overall structure of that region, potentially creating a metastable state of the molecule. If a conformational change is required for signaling by CheY D13K, then it most likely proceeds dynamically, in solution

Generalized Berry Conjecture and mode correlations in chaotic plates

We consider a modification of the Berry Conjecture for eigenmode statistics in wave-bearing systems. The eigenmode correlator is conjectured to be proportional to the imaginary part of the Green's function. The generalization is applicable not only to scalar waves in the interior of homogeneous isotropic systems where the correlator is a Bessel function, but to arbitrary points of heterogeneous systems as well. In view of recent experimental measurements, expressions for the intensity correlator in chaotic plates are derived.Comment: 5 pages, 1 figur

Consistency of pacing and metabolic responses during 2000-m rowing ergometry

PURPOSE: This study investigated the pacing strategy adopted and the consistency of performance and related physiological parameters across three 2000-m rowing-ergometer tests. METHODS: Fourteen male well-trained rowers took part in the study. Each participant performed three 2000-m rowing-ergometer tests interspersed by 3-7 d. Throughout the trials, respiratory exchange and heart rate were recorded and power output and stroke rate were analyzed over each 500 m of the test. At the completion of the trial, assessments of blood lactate and rating of perceived exertion were measured. RESULTS: Ergometer performance was unchanged across the 3 trials; however, pacing strategy changed from trial 1, which featured a higher starting power output and more progressive decrease in power, to trials 2 and 3, which were characterized by a more conservative start and an end spurt with increased power output during the final 500 m. Mean typical error (TE; %) across the three 2000-m trials was 2.4%, and variability was low to moderate for all assessed physiological variables (TE range = 1.4-5.1%) with the exception of peak lactate (TE = 11.5%). CONCLUSIONS: Performance and physiological responses during 2000-m rowing ergometry were found to be consistent over 3 trials. The variations observed in pacing strategy between trial 1 and trials 2 and 3 suggest that a habituation trial is required before an intervention study and that participants move from a positive to a reverse-J-shaped strategy, which may partly explain conflicting reports in the pacing strategy exhibited during 2000-m rowing-ergometer trials

Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria

There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal transmission. We hypothesize that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimize transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the basic reproduction number R0 to investigate how transmission potential varies with relapse frequency and seasonality. In tropical zones with year-round transmission, transmission potential is optimized at intermediate relapse frequencies of two to three months: slower-relapsing strains increase the opportunity for onward transmission to mosquitoes, but also increase the risk of being outcompeted by faster-relapsing strains. Seasonality is an important driver of relapse frequency for temperate strains, with the time to first relapse predicted to be six to nine months, coinciding with the duration between seasonal transmission peaks. We predict that there is a threshold degree of seasonality, below which fast-relapsing tropical strains are selected for, and above which slow-relapsing temperate strains dominate, providing an explanation for the observed global distribution of relapse phenotypes

The polar expression of ENSO and sea-ice variability as recorded in a South Pole ice core

An annually dated ice core recovered from South Pole (2850 m a.s.l.) in 1995, that covers the period 1487–1992, was analyzed for the marine biogenic sulfur species methanesulfonate (MS). Empirical orthogonal function analysis is used to calibrate the high-resolution MS series with associated environmental series for the period of overlap (1973–92). Utilizing this calibration we present a ~500 year long proxy record of the polar expression of the El Niño–Southern Oscillation (ENSO) and southeastern Pacific sea-ice extent variations. These records reveal short-term periods of increased (1800–50, 1900–40) and decreased sea-ice extent (1550–1610, 1660–1710, 1760–1800). In general, increased (decreased) sea-ice extent is associated with a higher (lower) frequency of El Niño events

Modulation of Autophagy-Like Processes by Tumor Viruses

Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases, including those caused by viral infection. Many viruses have evolved strategies to directly interfere with autophagy, presumably to facilitate their replication or to escape immune detection. However, in some cases, modulation of autophagy appears to be a consequence of the virus disturbing the cell’s metabolic signaling networks. Here, we summarize recent advances in research at the interface of autophagy and viral infection, paying special attention to strategies that human tumor viruses have evolved

Generalizing Tsirelson's bound on Bell inequalities using a min-max principle

Bounds on the norm of quantum operators associated with classical Bell-type inequalities can be derived from their maximal eigenvalues. This quantitative method enables detailed predictions of the maximal violations of Bell-type inequalities.Comment: 4 pages, 2 figures, RevTeX4, replaced with published versio