52 research outputs found

    Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

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    Copyright: Copyright 2012 Elsevier B.V., All rights reserved.Background: Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy) persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of Borrelia burgdorferi infection. The study included 25 patients with clinical stage - erythema migrans and 30 control (healthy) persons. HLA genotyping was performed by PCR with sequence-specific primers. Results: The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 *04 (OR 11.24; p<0.007) and HLA-DRB1 *17 (03) (OR 8.05; p<0.033) were increased in the Lyme disease patients. And the frequency of allele DRB1*13 (OR 0.12; p<0.017) was lower in Borreliosis patients and higher in control group. But, significant differences in frequencies of HLA-DQ alleles we did not detect. Conclusions: HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB1*04 and DRB1 *17 (03) may contribute to the Lyme borreliosis development in Latvian population.publishersversionPeer reviewe

    EXCITATION OF WAVES OF SOLITONE TYPE BY DISCRETE BREATHERS

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    In this paper, by the method of molecular dynamics studies the possibility of exciting soliton-type waves near the surface of a crystal, as well as their propagation deep into the crystal. The intermetallic compound Pt3Al, which supports the existence of discrete breathers with a soft type of nonlinearity, was chosen as the material under consideration. The role of discrete breathers in the formation of solitary waves is shown, their propagation through the crystal is studied.В работе методом молекулярной динамики изучается возможность возбуждения волн солитонного типа вблизи поверхности кристалла, а также их распространение вглубь кристалла. В качестве рассматриваемого материала выбрано интерметаллическое соединение Pt3Al, поддерживающее существование дискретных бризеров с мягким типом нелинейности. Показана роль дискретных бризеров в формировании уединенных волн, изучено их распространение по кристаллу.Работа выполнена при финансовой поддержке РНФ, проект № 16-12-10175

    KIDNEY TRANSPLANTATION AND DISTAL SPLENORENAL VENOUS ANASTOMOSIS IN THE TREATMENT OF DIABETIC NEPHROPATHY

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    A cadaveric kidney transplantation (KT) combined with distal venous splenorenal anastomosis is suggested as the surgical method for type 1 diabetes treatment (Shraer T.I.). This kind of operation was performed in 3 patients with the late stage of diabetic nephropathy (plasma creatinine 0,35–0,49 mmol/l). The results of our analysis showed positive influence of the above mentioned surgical treatment, reflect on the diabetes nephropathy, neuropathy and angiopathy

    Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science

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    It is well documented that the majority of adults, children and families in need of evidence-based behavioral health interventionsi do not receive them [1, 2] and that few robust empirically supported methods for implementing evidence-based practices (EBPs) exist. The Society for Implementation Research Collaboration (SIRC) represents a burgeoning effort to advance the innovation and rigor of implementation research and is uniquely focused on bringing together researchers and stakeholders committed to evaluating the implementation of complex evidence-based behavioral health interventions. Through its diverse activities and membership, SIRC aims to foster the promise of implementation research to better serve the behavioral health needs of the population by identifying rigorous, relevant, and efficient strategies that successfully transfer scientific evidence to clinical knowledge for use in real world settings [3]. SIRC began as a National Institute of Mental Health (NIMH)-funded conference series in 2010 (previously titled the “Seattle Implementation Research Conference”; $150,000 USD for 3 conferences in 2011, 2013, and 2015) with the recognition that there were multiple researchers and stakeholdersi working in parallel on innovative implementation science projects in behavioral health, but that formal channels for communicating and collaborating with one another were relatively unavailable. There was a significant need for a forum within which implementation researchers and stakeholders could learn from one another, refine approaches to science and practice, and develop an implementation research agenda using common measures, methods, and research principles to improve both the frequency and quality with which behavioral health treatment implementation is evaluated. SIRC’s membership growth is a testament to this identified need with more than 1000 members from 2011 to the present.ii SIRC’s primary objectives are to: (1) foster communication and collaboration across diverse groups, including implementation researchers, intermediariesi, as well as community stakeholders (SIRC uses the term “EBP champions” for these groups) – and to do so across multiple career levels (e.g., students, early career faculty, established investigators); and (2) enhance and disseminate rigorous measures and methodologies for implementing EBPs and evaluating EBP implementation efforts. These objectives are well aligned with Glasgow and colleagues’ [4] five core tenets deemed critical for advancing implementation science: collaboration, efficiency and speed, rigor and relevance, improved capacity, and cumulative knowledge. SIRC advances these objectives and tenets through in-person conferences, which bring together multidisciplinary implementation researchers and those implementing evidence-based behavioral health interventions in the community to share their work and create professional connections and collaborations

    Outbreak of enteroviral meningitis in Latvia, August – October 2006

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    Since August 2006, there has been a rapid increase in clinical cases of aseptic meningitis due to enterovirus in several areas of eastern Latvia. By 27 September, 258 cases had been registered in the two regions of Rezekne and Daugavpils.</jats:p

    Communicable disease surveillance, prevention and control in Latvia

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    The Latvian public health service dates back to 1947. The Sanitary Epidemiological Service, created in Soviet times, provided two main functions – assessment of health risk factors, including surveillance of communicable diseases, and inspection.</jats:p

    Tickborne encephalitis in Latvia

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    TBE has been notifiable in Latvia since 1955.</jats:p
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