Improved Theory of the Muonium Hyperfine Structure

Terms contributing to the hyperfine structure of the muonium ground state at the level of few tenths of kHz have been evaluated. The $\alpha^2 (Z\alpha)$ radiative correction has been calculated numerically to the precision of 0.02 kHz. Leading $\ln (Z\alpha )$ terms of order $\alpha^{4-n} (Z\alpha)^n , n=1,2,3,$ and some relativistic corrections have been evaluated analytically. The theoretical uncertainty is now reduced to 0.17 kHz. At present, however, it is not possible to test QED to this precision because of the 1.34 kHz uncertainty due to the muon mass.Comment: 11 pages + 2 figures (included), RevTeX 3.0, CLNS 94/127

High Order QED Corrections in Physics of Positronium

High-order perturbative corrections to positronium decays and hyperfine splitting are briefly reviewed. Theoretical predictions are compared to the most recent experimental data. Perspectives of future calculations are discussed.Comment: 8 pages, LaTeX, talk given at Workshop on Positronium Physics, ETH Honggerberg, Zurich, May 30-31, 2003, a misprint in Eq. (1) correcte

Radiative Corrections to the Muonium Hyperfine Structure. I. The α2(Zα)\alpha^2 (Z\alpha) Correction

This is the first of a series of papers on a systematic application of the NRQED bound state theory of Caswell and Lepage to higher-order radiative corrections to the hyperfine structure of the muonium ground state. This paper describes the calculation of the $\alpha^2 (Z\alpha)$ radiative correction. Our result for the complete $\alpha^2 (Z\alpha)$ correction is 0.424(4) kHz, which reduces the theoretical uncertainty significantly. The remaining uncertainty is dominated by that of the numerical evaluation of the nonlogarithmic part of the $\alpha (Z\alpha )^2$ term and logarithmic terms of order $\alpha^4$.Comment: 56 pages, Rev.tex V3.0 and epsf.tex. 12 postscript files are called in the text. Version accepted by Phys. Rev. D. A new table is adde

Thermal Properties of Two-Dimensional Advection Dominated Accretion Flow

We study the thermal structure of the widely adopted two-dimensional advection dominated accretion flow (ADAF) of Narayan & Yi (1995a). The critical radius for a given mass accretion rate, outside of which the optically thin hot solutions do not exist in the equatorial plane, agrees with one-dimensional study. However, we find that, even within the critical radius, there always exists a conical region of the flow, around the pole, which cannot maintain the assumed high electron temperature, regardless of the mass accretion rate, in the absence of radiative heating. This could lead to torus-like advection inflow shape since, in general, the ions too will cool down. We also find that Compton preheating is generally important and, if the radiative efficiency, defined as the luminosity output divided by the mass accretion rate times the velocity of light squared, is above sim 4x10^-3, the polar region of the flow is preheated above the virial temperature by Compton heating and it may result in time-dependent behaviour or outflow while accretion continues in the equatorial plane. Thus, under most relevant circumstances, ADAF solutions may be expected to be accompanied by polar outflow winds. While preheating instabilities exist in ADAF, as for spherical flows, the former are to some extent protected by their characteristically higher densities and higher cooling rates, which reduce their susceptibility to Compton driven overheating.Comment: 18 pages including 4 figures. AASTEX. Submitted to Ap

Order alpha^3 ln(1/alpha) Corrections to Positronium Decays

The logarithmically enhanced alpha^3 ln(1/alpha) corrections to the para- and orthopositronium decay widths are calculated in the framework of dimensionally regularized nonrelativistic quantum electrodynamics.In the case of parapositronium, the correction is negative, approximately doubles the effect of the leading logarithmic alpha^3 ln^2(1/alpha) one, and is comparable to the nonlogarithmic O(alpha^2) one. As for orthopositronium, the correction is positive and almost cancels the alpha^3 ln^2(1/alpha) one. The uncertainties in the theoretical predictions for the decay widths are reduced.Comment: 10 pages (Latex); missing term added, corrected coefficient B_p used, numerical results insignificantly change

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling

Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process. In the present study, we investigated how the inflammatory mediator NO can affect proliferation of neural stem cells (NSCs), and explored possible mechanisms underlying this effect. We investigated which mechanisms are involved in the regulation of NSC proliferation following treatment with an inflammatory stimulus (lipopolysaccharide plus IFN-gamma), using a culture system of subventricular zone (SVZ)-derived NSCs mixed with microglia cells obtained from wild-type mice (iNOS(+/+)) or from iNOS knockout mice (iNOS(-/-)). We found an impairment of NSC cell proliferation in iNOS(+/+) mixed cultures, which was not observed in iNOS(-/-) mixed cultures. Furthermore, the increased release of NO by activated iNOS(+/+) microglial cells decreased the activation of the ERK/MAPK signaling pathway, which was concomitant with an enhanced nitration of the EGF receptor. Preventing nitrogen reactive species formation with MnTBAP, a scavenger of peroxynitrite (ONOO-), or using the ONOO- degradation catalyst FeTMPyP cell proliferation and ERK signaling were restored to basal levels in iNOS(+/+) mixed cultures. Moreover, exposure to the NO donor NOC-18 (100 mu M), for 48 h, inhibited SVZ-derived NSC proliferation. Regarding the antiproliferative effect of NO, we found that NOC-18 caused the impairment of signaling through the ERK/MAPK pathway, which may be related to increased nitration of the EGF receptor in NSC. Using MnTBAP nitration was prevented, maintaining ERK signaling, rescuing NSC proliferation. We show that NO from inflammatory origin leads to a decreased function of the EGF receptor, which compromised proliferation of NSC. We also demonstrated that NO-mediated nitration of the EGF receptor caused a decrease in its phosphorylation, thus preventing regular proliferation signaling through the ERK/MAPK pathway.Foundation for Science and Technology, (FCT, Portugal); COMPETE; FEDER [PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014, PTDC/SAU-NEU/102612/2008, PTDC/NEU-OSD/0473/2012]; FCT, Portugal [SERH/BPD/78901/2011, SERH/BD/38127/2007, SFRH/BD/77903/2011, SFRH/BD/79308/2011]info:eu-repo/semantics/publishedVersio

Two-loop corrections to the decay rate of parapositronium

Order $\alpha^2$ corrections to the decay rate of parapositronium are calculated. A QED scattering calculation of the amplitude for electron-positron annihilation into two photons at threshold is combined with the technique of effective field theory to determine an NRQED Hamiltonian, which is then used in a bound state calculation to determine the decay rate. Our result for the two-loop correction is $5.1243(33)$ in units of $(\alpha/\pi)^2$ times the lowest order rate. This is consistent with but more precise than the result $5.1(3)$ of a previous calculation.Comment: 26 pages, 7 figure

Joining sustainable design and internet of things technologies on campus : the IPVC smartbottle practical case

Higher education institutions (HEIs) are favored environments for the implementation of technological solutions that accelerate the generation of smart campi, given the dynamic ecosystem they create based on the involvement of inspired and motivated human resources (students, professors, and researchers), moving around in an atmosphere of advanced digital infrastructures and services. Moreover, HEIs have, in their mission, not only the creation of integrated knowledge through Research and Development (R&D) activities but also solving societal problems that address the academic community expectations concerning environmental issues, contributing, therefore, towards a greener society embodied within the United Nations (UN) Sustainable Development Goals (SDGs). This article addresses the design and implementation of a Smartbottle Ecosystem in which an interactive and reusable water bottle communicates with an intelligent water refill station, both integrated by the Internet of Things (IoT) and Information and Communications Technologies (ICT), to eliminate the use of single-use plastic water bottles in the premises of the Polytechnical Institute of Viana do Castelo (IPVC), an HEI with nearly 6000 students. Three main contributions were identified in this research: (i) the proposal of a novel methodology based on the association of Design Thinking and Participatory Design as the basis for Sustainable Design; (ii) the design and development of an IoT-enabled smartbottle prototype; and (iii) the usability evaluation of the proposed prototype. The adopted methodology is rooted in Design Thinking and mixes it with a Participatory Design approach, including the end-user opinion throughout the Smartbottle Ecosystem design process, not only for the product design requirements but also for its specification. By promoting a participatory solution tailored to the IPVC academic community, recycled plastic has been identified as the preferential material and a marine mammal was selected for the smartbottle shape, in the process of developing a solution to replace the single-use plastic bottles.7519-C505-DF9E | Ant?nio Jos? Candeias CuradoN/