Barnacle Allergy in the Context of the Mites-Crustaceans-Molluscs-Cockroaches Syndrome

Introdução: A tropomiosina dos invertebrados é o pan-alergénio que une crustáceos, moluscos, aracnídeos, insectos e parasitas, encontrando-se significativa homologia de sequência entre as proteínas dos vários grupos. Os perceves são um tipo de crustáceo particularmente apreciado e consumido no nosso país; no entanto, a alergia a este crustáceo é uma situação bastante rara da qual só existe um trabalho publicado na literatura. Caso clínico: Apresentamos o caso de uma criança do sexo masculino, de 9 anos de idade, com asma brônquica, rinoconjuntivite alérgica e eczema atópico, sensibilizada a ácaros e baratas. Aos 7 anos, 10 minutos após a primeira ingestão de perceves, refere síndrome de alergia oral, angioedema periorbitário e rinoconjuntivite. Aos 8 anos, ocorreram 4 episódios semelhantes após ingestão de caracol, camarão, lula e choco (referindo ingestão prévia destes alimentos sem queixas). Aos 9 anos, refere episódio de urticária da face e angioedema periorbitário com inalação de vapores de cozedura de camarão. Foram realizados testes cutâneos por prick que se revelaram positivos para perceves, camarão, caracol, lula, choco, polvo e amêijoa em natureza, e para gamba, caranguejo e mexilhão com extractos comerciais. Os doseamentos de IgE específica sérica revelaram-se positivos para camarão, caracol, lula, polvo e amêijoa, bem como para perceves e tropomiosina recombinante. Foi efectuado SDS-PAGE immunoblotting com extracto de perceves que revelou várias fracções alergénicas com grande variação de pesos moleculares (19-88 kDa); foi ainda efectuado estudo de inibição com D. pteronyssinus, que inibiu várias fracções fixadoras de IgE no extracto de perceves. Discussão: Apresenta-se um caso raro de uma criança, com quadro de alergia respiratória associada a sensibilização a ácaros e baratas, com alergia alimentar a crustáceos –incluindo a perceves – e moluscos gastrópodes, bivalves e cefalópodes. Foram caracterizados os alergénios implicados na alergia a perceves e demonstrada a presença da tropomiosina como alergénio implicado, bem como a reactividade cruzada entre estes crustáceos e os ácaros

Detailed Classification of Swift's Gamma-Ray Bursts

Earlier classification analyses found three types of gamma-ray bursts (short, long and intermediate in duration) in the BATSE sample. Recent works have shown that these three groups are also present in the RHESSI and the BeppoSAX databases. The duration distribution analysis of the bursts observed by the Swift satellite also favors the three-component model. In this paper, we extend the analysis of the Swift data with spectral information. We show, using the spectral hardness and the duration simultaneously, that the maximum likelihood method favors the three-component against the two-component model. The likelihood also shows that a fourth component is not needed.Comment: Accepted for publication in The Astrophysical Journa

A Postprocessing methodology for direct normal irradiance forecasting using cloud information and aerosol load forecasts

A method for direct normal irradiance (DNI) forecasting for specific sites is proposed. It is based on the combination of a numerical weather prediction (NWP) model, which provides cloud information, with radiative transfer simulations fed with external aerosol forecasts. The NWP model used is the ECMWF Integrated Forecast System, and the radiative transfer information has been obtained from the Library of Radiative Transfer (libRadtran). Two types of aerosol forecasts have been tested: the global Monitoring Atmospheric Composition and Climate (MACC) model, which predicts five major components of aerosols, and the Dust Regional Atmospheric Model (BSC-DREAM8b) added to a fixed background calculated as the 20th percentile of the monthly mean of AERONET 2.0 observations from a different year. The methodology employed is valid for all meteorological situations, providing a stable and continuous DNI curve. The performance of the combined method has been evaluated against DNI observations and compared with the pure ECMWF forecasts at eight locations in the southern half of mainland Spain and the Canary Islands, which received high loadings of African dust for 2013 and 2014. Results for 1-day forecasts are presented. Although clouds play a major role, aerosols have a significant effect, but at shorter time scales. The combination of ECMWF and MACC forecasts gives the best global results, improving the DNI forecasts in events with high aerosol content. The regional BSC-DREAM8b yields good results for some extremely high dust conditions, although more reliable predictions, valid for any aerosol conditions, are provided by the MACC model

Searching for differences in Swift's intermediate GRBs

Gamma-ray bursts are usually classified through their high-energy emission into short-duration and long-duration bursts, which presumably reflect two different types of progenitors. However, it has been shown on statistical grounds that a third, intermediate population is needed in this classification scheme, although an extensive study of the properties of this class has so far not been done. The large amount of follow-up studies generated during the Swift era allows us to have a suficient sample to attempt a study of this third population through the properties of their prompt emission and their afterglows. Our study is focused on a sample of GRBs observed by Swift during its first four years of operation. The sample contains those bursts with measured redshift since this allows us to derive intrinsic properties. Intermediate bursts are less energetic and have dimmer afterglows than long GRBs, especially when considering the X-ray light curves, which are on average one order of magnitude fainter than long bursts. There is a less significant trend in the redshift distribution that places intermediate bursts closer than long bursts. Except for this, intermediate bursts show similar properties to long bursts. In particular, they follow the Epeak vs. Eiso correlation and have, on average, positive spectral lags with a distribution similar to that of long bursts. Like long GRBs, they normally have an associated supernova, although some intermediate bursts have shown no supernova component. This study shows that intermediate bursts are different from short bursts and, in spite of sharing many properties with long bursts, there are some differences between them as well. We suggest that the physical difference between intermediate and long bursts could be that for the first the ejecta are thin shells while for the latter they are thick shells.Comment: Accepted for publication in Astronomy and Astrophysics. 16 pages, 17 figures, 5 table

High-speed 1.55 μm operation of low-temperature-grown GaAs-based resonant-cavity-enhanced p–i–n photodiodes

We report the design, growth, fabrication, and characterization of GaAs-based high-speed p–i–n photodiodes operating at 1.55 μm. A low-temperature-grown GaAs (LT-GaAs) layer was used as the absorption layer and the photoresponse was selectively enhanced at 1.55 μm using a resonant-cavity-detector structure. The bottom mirror of the resonant cavity was formed by a highly reflecting 15-pair GaAs/AlAs Bragg mirror. Molecular-beam epitaxy was used for wafer growth, where the active LT-GaAs layer was grown at a substrate temperature of 200 °C. The fabricated devices exhibited a resonance around 1548 nm. When compared to the efficiency of a conventional single-pass detector, an enhancement factor of 7.5 was achieved. Temporal pulse-response measurements were carried out at 1.55 μm. Fast pulse responses with 30 ps pulse-width and a corresponding 3 dB bandwidth of 11.2 GHz was measured.This work was supported by NATO Grant No. SfP971970, Turkish Department of Defense Grant No.KOBRA-001, Thales JP8.04, CAM 07N/0059/2002 and ‘‘NANOSELF’’ TIC2002-04096-C03-03. E.O. acknowledges partial support received from Turkish Academy of Sciences.Peer reviewe

GRB 021004: Tomography of a gamma-ray burst progenitor and its host galaxy

We analyse the distribution of matter around the progenitor star of gamma-ray burst GRB 021004 as well as the properties of its host galaxy with high-resolution echelle as well as near-infrared spectroscopy. Observations were taken by the 8.2m Very Large Telescope with the Ultraviolet and Visual Echelle spectrograph (UVES) and the Infrared Spectrometer And Array Camera (ISAAC) between 10 and 14 hours after the onset of the event. We report the first detection of emission lines from a GRB host galaxy in the near-infrared, detecting H-alpha and the [O III] doublet. These allow an independent measurement of the systemic redshift (z = 2.3304 +/- 0.0005) which is not contaminated by absorption as the Ly-alpha line is, and the deduction of properties of the host galaxy. From the visual echelle spectroscopy, we find several absorption line groups spanning a range of about 3,000 km/s in velocity relative to the redshift of the host galaxy. The absorption profiles are very complex with both velocity-broadened components extending over several 100 km/s and narrow lines with velocity widths of only 20 km/s. By analogy with QSO absorption line studies, the relative velocities,widths, and degrees of ionization of the lines ("line-locking", "ionization--velocity correlation") show that the progenitor had both an extremely strong radiation field and several distinct mass loss phases (winds). These results are consistent with GRB progenitors being massive stars, such as Luminous Blue Variables (LBVs) or Wolf--Rayet stars, providing a detailed picture of the spatial and velocity structure of the GRB progenitor star at the time of explosion. The host galaxy is a prolific star-forming galaxy with a SFR of about 40 solar masses per year.Comment: 11 pages, 5 figures. Accepted for publication in Astronomy and Astrophysics

Pre-ALMA observations of GRBs in the mm/submm range

GRBs generate an afterglow emission that can be detected from radio to X-rays during days, or even weeks after the initial explosion. The peak of this emission crosses the mm/submm range during the first hours to days, making their study in this range crucial for constraining the models. Observations have been limited until now due to the low sensitivity of the observatories in this range. We present observations of 10 GRB afterglows obtained from APEX and SMA, as well as the first detection of a GRB with ALMA, and put them into context with all the observations that have been published until now in the spectral range that will be covered by ALMA. The catalogue of mm/submm observations collected here is the largest to date and is composed of 102 GRBs, of which 88 had afterglow observations, whereas the rest are host galaxy searches. With our programmes, we contributed with data of 11 GRBs and the discovery of 2 submm counterparts. In total, the full sample, including data from the literature, has 22 afterglow detections with redshift ranging from 0.168 to 8.2. GRBs have been detected in mm/submm wavelengths with peak luminosities spanning 2.5 orders of magnitude, the most luminous reaching 10^33erg s^-1 Hz^-1. We observe a correlation between the X-ray brightness at 0.5 days and the mm/submm peak brightness. Finally we give a rough estimate of the distribution of peak flux densities of GRB afterglows, based on the current mm/submm sample. Observations in the mm/submm bands have been shown to be crucial for our understanding of the physics of GRBs, but have until now been limited by the sensitivity of the observatories. With the start of the operations at ALMA, the sensitivity will be increased by more than an order of magnitude. Our estimates predict that, once completed, ALMA will detect up to 98% of the afterglows if observed during the passage of the peak synchrotron emission.Comment: 23 pages, 14 figures, 5 tables (one big one!), Accepted for publication in A&A. Includes the first observation of a GRB afterglow with ALM

Barnacle Allergy: Allergen Characterization and Cross-Reactivity with Mites

Background: Barnacles are a type of seafood with worldwide distribution and abundant along the shores of temperate seas. They are particularly appreciated and regularly consumed in Portugal as well as in Spain, France and South America, but barnacle allergy is a rare condition of which there is only one reference in the indexed literature. The molecular allergens and possible cross-reactivity phenomena implicated (namely with mites) have not been established. Objective: To demonstrate the IgE-mediated allergy to barnacle and to identify the proteins implicated as well as possible cross-reactivity phenomena with mites. Methods: We report the clinical and laboratory data of five patients with documented IgE-mediated allergy to barnacle. The diagnosis was based on a suggestive clinical history combined with positive skin prick tests (SPT) to barnacle – prick to prick method. Two barnacle extracts were prepared (raw and cooked barnacle) and sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) and IgE-immunoblotting were performed. An immunoblotting inhibition assay with Dermatophagoides pteronyssinus was also done in order to evaluate cross-reactivity. Results: All patients had mite-related asthma and the allergic rhinoconjunctivitis; they all experienced mucocutaneous symptoms. All of them had positive SPT to barnacle, and the immunoblotting showed several allergenic fractions with a wide molecular weight range (19 – 94 kDa). The D. pteronyssinus extract inhibited several IgE-binding protein fractions in the barnacle extract. Conclusions: We describe five patients with IgE-mediated barnacle allergy. We also describe a group of IgEbinding+ proteins between 30 and 75 kDa as the allergenic fractions of this type of Crustacea. Cross-reactivity with D. pteronyssinus was demonstrated in two cases

Identifying the Location in the Host Galaxy of the Short GRB 111117A with the Chandra Sub-arcsecond Position

We present our successful Chandra program designed to identify, with sub-arcsecond accuracy, the X-ray afterglow of the short GRB 111117A, which was discovered by Swift and Fermi. Thanks to our rapid target of opportunity request, Chandra clearly detected the X-ray afterglow, though no optical afterglow was found in deep optical observations. The host galaxy was clearly detected in the optical and near-infrared band, with the best photometric redshift of z=1.31_{-0.23}^{+0.46} (90% confidence), making it one of the highest known short GRB redshifts. Furthermore, we see an offset of 1.0 +- 0.2 arcseconds, which corresponds to 8.4 +- 1.7 kpc, between the host and the afterglow position. We discuss the importance of using Chandra for obtaining sub-arcsecond X-ray localizations of short GRB afterglows to study GRB environments.Comment: 17 pages, 11 figures, accepted for publication in Ap