Measurement of σ(Hνeνeˉ)×BR(H→ZZ∗){\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)} and Higgs production in ZZZZ fusion at a 1.4 TeV CLIC collider

This paper presents the potential measurement at 1.4 TeV CLIC of the cross-section (times branching ratio) of the Higgs production via $WW$ fusion with the Higgs subsequently decaying in $ZZ^\ast$, ${\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)}$, and of the Higgs production via $ZZ$ fusion with the Higgs subsequently decaying in $b\bar{b}$, ${\sigma(He{^+}e{^-})\times BR(H\rightarrow b\bar{b})}$. For the $H\rightarrow ZZ^\ast$ decay the hadronic final state, ${ZZ^\ast\rightarrow q\bar{q}q\bar{q}}$, and the semi-leptonic final state, ${ZZ^\ast\rightarrow q\bar{q}l^+l^-}$, are considered. The results show that ${\sigma(H\nu_e\bar{\nu_e})\times BR(H\rightarrow ZZ^\ast)}$ can be measured with a precision of 18.3% and 6% for the hadronic and semi-leptonic channel, respectively. ${\sigma(He{^+}e{^-})\times BR(H\rightarrow b\bar{b})}$ can be measured with a precision of 1.7%. This measurement also contributes to the determination of the Higgs coupling to the $Z$ boson, $g_{H_{ZZ}}$.Comment: Talk presented at the International Workshop on Future Linear Colliders (LCWS14), Belgrade, Serbia, 6-10 October 201

Multi-waveband observations of colliding galaxies

Colliding galaxies represent a major challenge to both theorists and observers because of the large variety of phenomena which are expected to come into play during the interaction. Strong gravitational fluctuations may drive non-linear waves and instabilities throughout the stars and gas leading to enhanced star formation, nuclear activity and ultimately a mixing of the morphological components of the original galaxies. One relatively uncomplicated class of colliding galaxy where stellar waves play an important role in star formation are ring galaxies. Ring galaxies are probably formed when a companion galaxy passes through the center of a disk system driving circular waves through the disk (Lynds and Toomre 1976, Toomre 1978, Struck-Marcell 1990). Off-center collisions can generate non-circular waves and can be loosely described as banana-shaped although they may exhibit more complex forms as the waves expand into the disk. The propagation of such stellar and gaseous waves through the disk leads to enhanced star formation (e.g., Appleton and Struck-Marcell 1987a; Jeske 1986) and provides a unique probe of the response of the interstellar medium (ISM) to a propagating wave (see Appleton and Struck-Marcell 1987b). Here, the authors report results for 3 systems; the irregular ring Arp 143 (=VV 117); Wakamatsu's Seyfert ring (A0959-755; see Wakamatsu and Nishida 1987) and the brighter member of the pair of ring galaxies comprising of AM 1358-221. The most complete multi-wavelength data is for Arp 143. Optical charge coupled device (CCD) observations made with the 60 inch Palomar telescope at BV and r band, near-IR images at J (1.25 microns), H (1.65 microns) and k (2.2 microns) bands from the infrared camera (IRCAM) InSb array camera on the 3.8m United Kingdon Infrared Telescope (UKIRT) telescope and very large array (VLA) observations at 20cm in both the neutral hydrogen line and radio continuum are described. The observations of Wakamatsu's ring and AM 1358 were made only in the near-IR, and a comparison is made with available optical plate material

SCUBA - A submillimetre camera operating on the James Clerk Maxwell Telescope

The Submillimetre Common-User Bolometer Array (SCUBA) is one of a new generation of cameras designed to operate in the submillimetre waveband. The instrument has a wide wavelength range covering all the atmospheric transmission windows between 300 and 2000 microns. In the heart of the instrument are two arrays of bolometers optimised for the short (350/450 microns) and long (750/850 microns) wavelength ends of the submillimetre spectrum. The two arrays can be used simultaneously, giving a unique dual-wavelength capability, and have a 2.3 arc-minute field of view on the sky. Background-limited performance is achieved by cooling the arrays to below 100 mK. SCUBA has now been in active service for over a year, and has already made substantial breakthroughs in many areas of astronomy. In this paper we present an overview of the performance of SCUBA during the commissioning phase on the James Clerk Maxwell Telescope (JCMT).Comment: 14 pages, 13 figures (1 JPEG), Proc SPIE vol 335

E-Curator: A 3D Web-based Archive for Conservators and Curators

Mona Hess, Graeme Were, Ian Brown, Sally MacDonald, Stuart Robson and Francesca Simon Millar describe a project which combines 3D colour laser scanning and e-Science technologies for capturing and sharing very large 3D scans and datasets about museum artefacts in a secure computing environment

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes

Epitope-tagged active-site-directed probes are widely used to visualize the activity of deubiquitinases (DUBs) in cell extracts, to investigate the specificity and potency of small-molecule DUB inhibitors, and to isolate and identify DUBs by mass spectrometry. With DUBs arising as novel potential drug targets, probes are required that can be produced in sufficient amounts and to meet the specific needs of a given experiment. The established method for the generation of DUB probes makes use of labor-intensive intein-based methods that have inherent limitations concerning the incorporation of unnatural amino acids and the amount of material that can be obtained. Here, we describe the total chemical synthesis of active-site-directed probes and their application to activity-based profiling and identification of functional DUBs. This synthetic methodology allowed the easy incorporation of desired tags for specific applications, for example, fluorescent reporters, handles for immunoprecipitation or affinity pull-down, and cleavable linkers. Additionally, the synthetic method can be scaled up to provide significant amounts of probe. Fluorescent ubiquitin probes allowed faster, in-gel detection of active DUBs, as compared to (immuno)blotting procedures. A biotinylated probe holding a photocleavable linker enabled the affinity pull-down and subsequent mild, photorelease of DUBs. Also, DUB activity levels were monitored in response to overexpression or knockdown, and to inhibition by small molecules. Furthermore, fluorescent probes revealed differential DUB activity profiles in a panel of lung and prostate cancer cells

An anatomy of the cooling of the North Atlantic Ocean in the 1960s and 1970s

In the 1960s and early 1970s sea surface temperatures in the North Atlantic Ocean cooled rapidly. There is still considerable uncertainty about the causes of this event, although various mechanisms have been proposed. In this observational study it is demonstrated that the cooling proceeded in several distinct stages. Cool anomalies initially appeared in the mid-1960s in the Nordic Seas and Gulf Stream Extension, before spreading to cover most of the Subpolar Gyre. Subsequently, cool anomalies spread into the tropical North Atlantic before retreating, in the late 1970s, back to the Subpolar Gyre. There is strong evidence that changes in atmospheric circulation, linked to a southward shift of the Atlantic ITCZ, played an important role in the event, particularly in the period 1972-76. Theories for the cooling event must account for its distinctive space-time evolution. Our analysis suggests that the most likely drivers were: 1) The “Great Salinity Anomaly” of the late 1960s; 2) An earlier warming of the subpolar North Atlantic, which may have led to a slow-down in the Atlantic Meridional Overturning Circulation; 3) An increase in anthropogenic sulphur dioxide emissions. Determining the relative importance of these factors is a key area for future work

Mammographic image restoration using maximum entropy deconvolution

An image restoration approach based on a Bayesian maximum entropy method (MEM) has been applied to a radiological image deconvolution problem, that of reduction of geometric blurring in magnification mammography. The aim of the work is to demonstrate an improvement in image spatial resolution in realistic noisy radiological images with no associated penalty in terms of reduction in the signal-to-noise ratio perceived by the observer. Images of the TORMAM mammographic image quality phantom were recorded using the standard magnification settings of 1.8 magnification/fine focus and also at 1.8 magnification/broad focus and 3.0 magnification/fine focus; the latter two arrangements would normally give rise to unacceptable geometric blurring. Measured point-spread functions were used in conjunction with the MEM image processing to de-blur these images. The results are presented as comparative images of phantom test features and as observer scores for the raw and processed images. Visualization of high resolution features and the total image scores for the test phantom were improved by the application of the MEM processing. It is argued that this successful demonstration of image de-blurring in noisy radiological images offers the possibility of weakening the link between focal spot size and geometric blurring in radiology, thus opening up new approaches to system optimization.Comment: 18 pages, 10 figure

Robust multi-year climate impacts of volcanic eruptions in decadal prediction systems

Major tropical volcanic eruptions have a large impact on climate, but there have only been three major eruptions during the recent relatively well-observed period. Models are therefore an important tool to understand and predict the impacts of an eruption. This study uses five state-of-the-art decadal prediction systems that have been initialized with the observed state before volcanic aerosols are introduced. The impact of the volcanic aerosols is found by subtracting the results of a reference experiment where the volcanic aerosols are omitted. We look for the robust impact across models and volcanoes by combining all the experiments, which helps reveal a signal even if it is weak in the models. The models used in this study simulate realistic levels of warming in the stratosphere, but zonal winds are weaker than the observations. As a consequence, models can produce a pattern similar to the North Atlantic Oscillation in the first winter following the eruption, but the response and impact on surface temperatures is weaker than in observations. Reproducing the pattern, but not the amplitude, may be related to a known model error. There are also impacts in the Pacific and Atlantic Oceans. This work contributes towards improving the interpretation of decadal predictions in the case of a future large tropical volcanic eruption

A historic jet-emission minimum reveals hidden spectral features in 3C 273

Aims. The aim of this work is to identify and study spectral features in the quasar 3C 273 usually blended by its strong jet emission. Method. A historic minimum in the sub-millimetre emission of 3C 273 triggered coordinated multi-wavelength observations in June 2004. X-ray observations from the INTEGRAL, XMM-Newton and RXTE satellites are complemented by ground-based optical, infrared, millimetre and radio observations. The overall spectrum is used to model the infrared and X-ray spectral components. Results. Three thermal dust emission components are identified in the infrared. The dust emission on scales from 1 pc to several kpc is comparable to that of other quasars, as expected by AGN unification schemes. The observed weakness of the X-ray emission supports the hypothesis of a synchrotron self-Compton origin for the jet component. There is a clear soft-excess and we find evidence for a very broad iron line which could be emitted in a disk around a Kerr black hole. Other signatures of a Seyfert-like X-ray component are not detected.Comment: 4 pages. Accepted for publication in A&A Letter