Denoising Criterion for Variational Auto-Encoding Framework

Denoising autoencoders (DAE) are trained to reconstruct their clean inputs with noise injected at the input level, while variational autoencoders (VAE) are trained with noise injected in their stochastic hidden layer, with a regularizer that encourages this noise injection. In this paper, we show that injecting noise both in input and in the stochastic hidden layer can be advantageous and we propose a modified variational lower bound as an improved objective function in this setup. When input is corrupted, then the standard VAE lower bound involves marginalizing the encoder conditional distribution over the input noise, which makes the training criterion intractable. Instead, we propose a modified training criterion which corresponds to a tractable bound when input is corrupted. Experimentally, we find that the proposed denoising variational autoencoder (DVAE) yields better average log-likelihood than the VAE and the importance weighted autoencoder on the MNIST and Frey Face datasets.Comment: ICLR conference submissio

13C-Methyl isocyanide as an NMR probe for cytochrome P450 active site

The cytochromes P450 (CYPs) play a central role in many biologically important oxidation reactions, including the metabolism of drugs and other xenobiotic compounds. Because they are often assayed as both drug targets and anti-targets, any tools that provide: (a) confirmation of active site binding and (b) structural data, would be of great utility, especially if data could be obtained in reasonably high throughput. To this end, we have developed an analog of the promiscuous heme ligand, cyanide,with a 13CH3-reporter attached. This 13C-methyl isocyanide ligand binds to bacterial (P450cam) and membrane-bound mammalian (CYP2B4) CYPs. It can be used in a rapid 1D experiment to identify binders, and provides a qualitative measure of structural changes in the active site

An exploration of the utilities of terahertz waves for the NDE of composites

We report an investigation of terahertz waves for the nondestructive evaluation of composite materials and structures. The modalities of the terahertz radiation used were time domain spectroscopy (TDS) and continuous wave (CW). The composite materials and structures investigated include both non‐conducting polymeric composites and carbon fiber composites. Terahertz signals in the TDS mode resembles that of ultrasound; however, unlike ultrasound, a terahertz pulse can detect a crack hidden behind a larger crack. This was demonstrated in thick GFRP laminates containing double saw slots. In carbon composites the penetration of terahertz waves is quite limited and the detection of flaws is strongly affected by the angle between the electric field vector of the terahertz waves and the intervening fiber directions. The structures tested in this study include both solid laminates and honeycomb sandwiches. The defects and anomalies investigated by terahertz waves were foreign material inclusions, simulated disbond and delamination, mechanical impact damage, heat damage, and water or hydraulic fluid ingression. The effectiveness and limitations of terahertz radiation for the NDE of composites are discussed

Influence of terahertz waves on the fiber direction of CFRP composite laminates

The importance of Carbon-fiber reinforced plastics (CFRP) are widely utilized due to more high performance in engineering structures. It was well known that a nondestructive technique would be very beneficial. A new terahertz radiation has been recognized for their importance in technological applications. Recently, T-ray (terahertz ray) advances of technology and instrumentation has provided a probing field on the electromagnetic spectrum. The THz-TDS can be considered as a useful tool using general non-conducting materials; however it is quite limited to conducting materials. In order to solve various material properties, the index of refraction (n) and the absorption coefficient (α) are derived in reflective and transmission configuration using the terahertz time domain spectroscopy. However, the T-ray is limited in order to penetrate a conducting material to some degree. Here, the T-ray would not go through easily the CFRP composite laminates since carbon fibers are electrically conducting while the epoxy matrix is not. So, investigation of terahertz time domain spectroscopy (THz TDS) was made and reflection and transmission configurations were studied for a 48-ply thermoplastic PPS (poly-phenylene sulfide)-based CFRP solid laminate. It is found that the electrical conductivity of CFRP composites depends on the direction of unidirectional fibers. Also, the T-ray could penetrate a CFRP composite laminate a few ply based on the E-filed (Electrical field) of carbon fibers. The terahertz scanning images were made at the angles ranged from 0° to 180° with respect to the nominal fiber axis. So, the images were mapped out based on the electrical field (E-field) direction in the CFRP solid laminates. Also, using two-dimensional spatial Fourier transform, interface C-scan images were transformed into quantitatively angular distribution plots to show the fiber orientation information therein and to predict the orientation of the ply

Challenging perspectives on the cellular origins of lymphoma.

Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering antigen via this receptor or its precursor, and they have the capacity to be extremely long lived as 'memory' cells. All three of these traits are fundamental to their ability to function as the adaptive immune response to infectious agents, but concurrently render these cells vulnerable to transformation. Thus, it is classically considered that lymphomas arise at a relatively late stage in a lymphocyte's development during the process of modifying diversity within antigen receptors, and when the cell is capable of responding to stimulus via its receptor. Attempts to understand the aetiology of lymphoma have reinforced this notion, as the most notable advances to date have shown chronic stimulation of the antigen receptor by infectious agents or self-antigens to be key drivers of these diseases. Despite this, there is still uncertainty about the cell of origin in some lymphomas, and increasing evidence that a subset arises in a more immature cell. Specifically, a recent study indicates that T-cell lymphoma, in particular nucleophosmin-anaplastic lymphoma kinase-driven anaplastic large cell lymphoma, may originate in T-cell progenitors in the thymus.T.I.M.M. was supported by a Bloodwise Gordon Piller Studentship.This is the final version of the article. It first appeared from The Royal Society via https://doi.org/10.1098/rsob.16023

Signal Modeling in the Far-Infrared Region for Nondestructive Evaluation Applicatinos

Terahertz radiation (a.k.a. T‐ray) has emerged as a powerful inspection technique in recent years. It extends into the lower region of far‐infrared in the electromagnetic spectrum, and has been proven very effective in many NDE applications. T‐ray is particularly useful in some areas where accessibility is difficult or even not possible for other conventional NDE methods. Here we report a modeling effort of T‐ray signal in one such application: the detection of “hidden delamination”, a special situation that a delamination was shadowed by another. This special case was experimentally simulated by two parallel saw‐cuts in glass composites. In this paper, we also explore the feasibility of combing T‐ray and Fourier transform infrared spectroscopy using a unified least‐squares scheme for material characterization