Simultaneous BeppoSAX and Rossi X-ray Timing Explorer observations of 4U1812-12

4U1812-12 is a faint persistent and weakly variable neutron star X-ray binary. It was observed by BeppoSAX between April 20th and 21st, 2000 in a hard spectral state with a bolometric luminosity of ~2x10^36 ergs/s. Its broad band energy spectrum is characterized by the presence of a hard X-ray tail extending above ~100 keV. It can be represented as the sum of a dominant hard Comptonized component (electron temperature of ~36 keV and optical depth ~3) and a weak soft component. The latter component which can be fitted with a blackbody of about 0.6 keV and equivalent radius of ~2 km is likely to originate from the neutron star surface. We also report on the first measurement of the power density spectrum of the source rapid X-ray variability, as recorded during a simultaneous snapshot observation performed by the Rossi X-ray Timing Explorer. As expected for a neutron star system in such hard spectral state, its power density spectrum is characterized by the presence of a ~0.7 Hz low frequency quasi-periodic oscillation together with three broad noise components, one of which extends above ~200 Hz.Comment: 6 pages, 3 figures, accepted for publication in A&

On the nature of two low M-dot X-ray bursters: 1RXS J170854.4-321857 and 1RXS J171824.2-402934

We carried out Chandra observations of two low-luminosity low-mass X-ray binaries, 1RXS J170854.4-321857 and 1RXS J171824.2-402934, for which previously single X-ray bursts had been detected with the Wide Field Cameras (WFCs) on board BeppoSAX. Both were detected in our Chandra observations in an actively accreting state three to eight years after the X-ray bursts, with 0.5-10 keV luminosities between 5x10^34 and 2x10^36 erg/s. The apparently persistent nature is remarkable for 1RXS J171824.2-402934 given its low luminosity of 0.001L_Edd. The persistence of both sources also distinguishes them from 5 other low-L bursters, which have also been seen during bursts with the WFCs but were not detected during Chandra observations above a luminosity of 10^33 erg/s. Those are probably transient rather than persistent sources.Comment: accepted for publication in Astronomy & Astrophysics, 7 pages, 5 figure

Restless quiescence: thermonuclear flashes between transient X-ray outbursts

For thermonuclear flashes to occur on neutron-star surfaces, fuel must have been accreted from a donor star. However, sometimes flashes are seen from transient binary systems when they are thought to be in their quiescent phase, during which no accretion, or relatively little, is expected to occur. We investigate the accretion luminosity during several such flashes, including the first-ever and brightest detected flash from Cen X-4 in 1969. We infer from observations and theory that immediately prior to these flashes the accretion rate must have been between about 0.001 and 0.01 times the equivalent of the Eddington limit, which is roughly 2 orders of magnitude less than the peak accretion rates seen in these transients during an X-ray outburst and 3-4 orders of magnitude more than the lowest measured values in quiescence. Furthermore, three such flashes, including the one from Cen X-4, occurred within 2 to 7 days followed by an X-ray outburst. A long-term episode of enhanced, but low-level, accretion is predicted near the end of the quiescent phase by the disk-instability model, and may thus have provided the right conditions for these flashes to occur. We discuss the possibility of whether these flashes acted as triggers of the outbursts, signifying a dramatic increase in the accretion rate. Although it is difficult to rule out, we find it unlikely that the irradiance by these flashes is sufficient to change the state of the accretion disk in such a dramatic way.Comment: 9 pages, 3 figures, accepted for publication in A&A; referee comments included plus improved text; results unchange

The INTEGRAL Galactic bulge monitoring program: the first 1.5 years

The Galactic bulge region is a rich host of variable high-energy point sources. Since 2005, February 17 we are monitoring the source activity in this region about every three days with INTEGRAL. Thanks to the large field of view, the imaging capabilities and the sensitivity at hard X-rays, we are able to present for the first time a detailed homogeneous (hard) X-ray view of a sample of 76 sources in the Galactic bulge region. We describe the successful monitoring program and show the first results for a period of about one and a half year. We focus on the short (hour), medium (month) and long-term (year) variability in the 20-60 keV and 60-150 keV bands. When available, we discuss the simultaneous observations in the 3-10 keV and 10-25 keV bands. Per visibility season we detect 32/33 sources in the 20-60 keV band and 8/9 sources in the 60-150 keV band. On average, we find per visibility season one active bright (>~100 mCrab, 20-60 keV) black-hole candidate X-ray transient and three active weaker (<~25 mCrab, 20-60 keV) neutron star X-ray transients. Most of the time a clear anti-correlation can be seen between the soft and hard X-ray emission in some of the X-ray bursters. Hard X-ray flares or outbursts in X-ray bursters, which have a duration of the order of weeks, are accompanied by soft X-ray drops. On the other hand, hard X-ray drops can be accompanied by soft X-ray flares/outbursts. We found a number of new sources, IGR J17354-3255, IGR 17453-2853, IGR J17454-2703, IGR J17456-2901b, IGR J17536-2339, and IGR J17541-2252. We report here on some of the high-energy properties of these sources. The high-energy light curves of all the sources in the field of view, and the high-energy images of the region, are made available through the WWW at http://isdc.unige.ch/Science/BULGE/.Comment: 27 pages, 42 figures, accepted for publication in A&A. Abstract abridged. Tables 3,4,6,7 appear at the end. Images have been compressed and are reduced in quality; original PostScript images can be retrieved from http://isdc.unige.ch/~kuulkers/bulge

Photospheric radius expansion X-ray bursts as standard candles

We examined the maximum bolometric peak luminosities during type I X-ray bursts from the persistent or transient luminous X-ray sources in globular clusters. We show that for about two thirds of the sources the maximum peak luminosities during photospheric radius expansion X-ray bursts extend to a critical value of (3.79+/-0.15)x10^{38} erg/s, assuming the total X-ray burst emission is entirely due to black-body radiation and the recorded maximum luminosity is the actual peak luminosity. This empirical critical luminosity is consistent with the Eddington luminosity limit for hydrogen poor material. Since the critical luminosity is more or less always reached during photospheric radius expansion X-ray bursts (except for one source), such bursts may be regarded as empirical standard candles. However, because significant deviations do occur, our standard candle is only accurate to within 15%. We re-evaluated the distances to the twelve globular clusters in which the X-ray bursters reside.Comment: Accepted for publication in A&A, 20 pages, 7 figure

Cancer incidence in the vicinity of Finnish nuclear power plants: an emphasis on childhood leukemia

The objective of this paper was to study cancer incidence, especially leukemia in children (<15 years), in the vicinity of Finnish nuclear power plants (NPPs). We used three different approaches: ecological analysis at municipality level, residential cohorts defined from census data, and case–control analysis with individual residential histories. The standardized incidence ratio of childhood leukemia for the seven municipalities in the vicinity of NPPs was 1.0 (95% CI 0.6, 1.6) compared to the rest of Finland. The two cohorts defined by censuses of 1980 and 1990 gave rate ratios of 1.0 (95% CI 0.3, 2.6) and 0.9 (95% CI 0.2, 2.7), respectively, for childhood leukemia in the population residing within 15 km from the NPPs compared to the 15–50 km zone. The case–control analysis with 16 cases of childhood leukemia and 64 matched population-based controls gave an odds ratio for average distance between residence and NPP in the closest 5–9.9 km zone of 0.7 (95% CI 0.1, 10.4) compared to ≥30 km zone. Our results do not indicate an increase in childhood leukemia and other cancers in the vicinity of Finnish NPPs though the small sample size limits the strength of conclusions. The conclusion was the same for adults

Phone and e-mail counselling are effective for weight management in an overweight working population: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>The work setting provides an opportunity to introduce overweight (i.e., Body Mass Index ≥ 25 kg/m²) adults to a weight management programme, but new approaches are needed in this setting. The main purpose of this study was to investigate the effectiveness of lifestyle counselling by phone or e-mail on body weight, in an overweight working population. Secondary purposes were to establish effects on waist circumference and lifestyle behaviours, and to assess which communication method is the most effective.</p> <p>Methods</p> <p>A randomized controlled trial with three treatments: intervention materials with phone counselling (phone group); a web-based intervention with e-mail counselling (internet group); and usual care, i.e. lifestyle brochures (control group). The interventions used lifestyle modification and lasted a maximum of six months. Subjects were 1386 employees, recruited from seven companies (67% male; mean age 43 (SD 8.6) y; mean BMI 29.6 (SD 3.5) kg/m²). Body weight was measured by research personnel and by questionnaire. Secondary outcomes fat, fruit and vegetable intake, physical activity and waist circumference were assessed by questionnaire. Measurements were done at baseline and after six months. Missing body weight was multiply imputed.</p> <p>Results</p> <p>Body weight reduced 1.5 kg (95% CI -2.2;-0.8, p < 0.001) in the phone group and 0.6 kg (95% CI -1.3; -0.01, p = 0.045) in the internet group, compared with controls. In completers analyses, weight and waist circumference in the phone group were reduced with 1.6 kg (95% CI -2.2;-1.0, p < 0.001) and 1.9 cm (95% CI -2.7;-1.0, p < 0.001) respectively, fat intake decreased with 1 fatpoint (1 to 4 grams)/day (95% CI -1.7;-0.2, p = 0.01) and physical activity increased with 866 METminutes/week (95% CI 203;1530, p = 0.01), compared with controls. The internet intervention resulted in a weight loss of 1.1 kg (95% CI -1.7;-0.5, p < 0.001) and a reduction in waist circumference of 1.2 cm (95% CI -2.1;-0.4, p = 0.01), in comparison with usual care. The phone group appeared to have more and larger changes than the internet group, but comparisons revealed no significant differences.</p> <p>Conclusion</p> <p>Lifestyle counselling by phone and e-mail is effective for weight management in overweight employees and shows potential for use in the work setting.</p> <p>Trial registration</p> <p>ISCRTN04265725.</p

INTEGRAL survey of the Cassiopeia region in hard X rays

We report on the results of a deep 1.6 Ms INTEGRAL observation of the Cassiopeia region performed from December 2003 to February 2004. Eleven sources were detected with the imager IBIS-ISGRI at energies above 20 keV, including three new hard X-ray sources. Most remarkable is the discovery of hard X-ray emission from the anomalous X-ray pulsar 4U 0142+61, which shows emission up to \~150 keV with a very hard power-law spectrum with photon index Gamma = 0.73 +/- 0.17. We derived flux upper limits for energies between 0.75 MeV and 30 MeV using archival data from the Compton telescope COMPTEL. In order to reconcile the very hard spectrum of 4U 0142+61 measured by INTEGRAL with the COMPTEL upper limits, the spectrum has to bend or break between ~75 keV and ~750 keV. 1E 2259+586, another anomalous X-ray pulsar in this region, was not detected. INTEGRAL and COMPTEL upper limits are provided. The new INTEGRAL sources are IGR J00370+6122 and IGR J00234+6144. IGR J00370+6122 is a new supergiant X-ray binary with an orbital period of 15.665 +/- 0.006 days, derived from RXTE All-Sky Monitor data. Archival BeppoSAX Wide-Field Camera data yielded four more detections. IGR J00234+6144 still requires a proper identification. Other sources for which INTEGRAL results are presented are high-mass X-ray binaries 2S 0114+650, Gamma~Cas, RX J0146.9+6121 and 4U 2206+54, intermediate polar V709 Cas and 1ES 0033+595, an AGN of the BL-Lac type. For each of these sources the hard X-ray spectra are fitted with different models and compared with earlier published results.Comment: 16 pages, 13 figures, accepted for publication in A&

NETosis in Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Its neuropathological features include amyloid-\u3b2 (A\u3b2) accumulation, the formation of neurofibrillary tangles, and the loss of neurons and synapses. Neuroinflammation is a well-established feature of AD pathogenesis, and a better understanding of its mechanisms could facilitate the development of new therapeutic approaches. Recent studies in transgenic mouse models of AD have shown that neutrophils adhere to blood vessels and migrate inside the parenchyma. Moreover, studies in human AD subjects have also shown that neutrophils adhere and spread inside brain vessels and invade the parenchyma, suggesting these cells play a role in AD pathogenesis. Indeed, neutrophil depletion and the therapeutic inhibition of neutrophil trafficking, achieved by blocking LFA-1 integrin in AD mouse models, significantly reduced memory loss and the neuropathological features of AD. We observed that neutrophils release neutrophil extracellular traps (NETs) inside blood vessels and in the parenchyma of AD mice, potentially harming the blood-brain barrier and neural cells. Furthermore, confocal microscopy confirmed the presence of NETs inside the cortical vessels and parenchyma of subjects with AD, providing more evidence that neutrophils and NETs play a role in AD-related tissue destruction. The discovery of NETs inside the AD brain suggests that these formations may exacerbate neuro-inflammatory processes, promoting vascular and parenchymal damage during AD. The inhibition of NET formation has achieved therapeutic benefits in several models of chronic inflammatory diseases, including autoimmune diseases affecting the brain. Therefore, the targeting of NETs may delay AD pathogenesis and offer a novel approach for the treatment of this increasingly prevalent disease