Discovery of Eight z ~ 6 Quasars in the Sloan Digital Sky Survey Overlap Regions

We present the discovery of eight quasars at z~6 identified in the Sloan Digital Sky Survey (SDSS) overlap regions. Individual SDSS imaging runs have some overlap with each other, leading to repeat observations over an area spanning >4000 deg^2 (more than 1/4 of the total footprint). These overlap regions provide a unique dataset that allows us to select high-redshift quasars more than 0.5 mag fainter in the z band than those found with the SDSS single-epoch data. Our quasar candidates were first selected as i-band dropout objects in the SDSS imaging database. We then carried out a series of follow-up observations in the optical and near-IR to improve photometry, remove contaminants, and identify quasars. The eight quasars reported here were discovered in a pilot study utilizing the overlap regions at high galactic latitude (|b|>30 deg). These quasars span a redshift range of 5.86<z<6.06 and a flux range of 19.3<z_AB<20.6 mag. Five of them are fainter than z_AB=20 mag, the typical magnitude limit of z~6 quasars used for the SDSS single-epoch images. In addition, we recover eight previously known quasars at z~6 that are located in the overlap regions. These results validate our procedure for selecting quasar candidates from the overlap regions and confirming them with follow-up observations, and provide guidance to a future systematic survey over all SDSS imaging regions with repeat observations.Comment: AJ in press (8 pages

The management of tree genetic resources and the livelihoods of rural communities in the tropics: non-timber forest products, smallholder agroforestry practices and tree commodity crops

Products and services provided by trees in forests and farmland support the needs and promote the wellbeing of hundreds of millions of people in the tropics. Value depends on managing both the diversity of tree species present in landscapes and the genetic variation within these species. The benefits from trees and their genetic resources are, however, often not well quantified because trade is frequently outside formal markets, there is a multiplicity of species and ways in which trees are used and managed, and genetic diversity within species is frequently not given proper consideration. We review here what is known about the value of trees to rural communities through considering three production categories: non-timber products harvested from trees in natural and managed forests and woodlands; the various products and services obtained from a wide range of trees planted and/or retained in smallholders’ agroforestry systems; and the commercial products harvested from cultivated tree commodity crops. Where possible, we focus on the role of intra-specific genetic variation in providing support to livelihoods, and for each of the three production categories we also consider wider conservation and sustainability issues, including the linkages between categories in terms of management. Challenges to ‘conventional wisdom’ on tree resource use, value and management – such as in the posited links between commercialisation, cultivation and conservation – are highlighted, and constraints and opportunities to maintain and enhance value are described

Probing Bottom-up Processing with Multistable Images

The selection of fixation targets involves a combination of top-down and bottom-up processing. The role of bottom-up processing can be enhanced by using multistable stimuli because their constantly changing appearance seems to depend predominantly on stimulusdriven factors. We used this approach to investigate whether visual processing models based on V1 need to be extended to incorporate specific computations attributed to V4. Eye movements of 8 subjects were recorded during free viewing of the Marroquin pattern in which illusory circles appear and disappear. Fixations were concentrated on features arranged in concentric rings within the pattern. Comparison with simulated fixation data demonstrated that the saliency of these features can be predicted with appropriate weighting of lateral connections in existing V1 models

Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

Interferon lambda (IFNλ) is a group of cytokines that belong to the IL-10 family. They exhibit antiviral activities against certain viruses during infection of the liver and mucosal tissues. Here we report that IFNλ restricts in vitro replication of the β-herpesvirus murine cytomegalovirus (mCMV). However, IFNλR1-deficient (Ifnλr1-/-) mice were not preferentially susceptible to mCMV infection in vivo during acute infection after systemic or mucosal challenge, or during virus persistence in the mucosa. Instead, our studies revealed that IFNλ influences NK cell responses during mCMV infection. Ifnλr1-/- mice exhibited defective development of conventional interferon-gamma (IFNγ)-expressing NK cells in the spleen during mCMV infection whereas accumulation of granzyme B-expressing NK cells was unaltered. In vitro, development of splenic IFNγ+ NK cells following stimulation with IL-12 or, to a lesser extent, IL-18 was abrogated by IFNλR1-deficiency. Thus, IFNλ regulates NK cell responses during mCMV infection and restricts virus replication in vitro but is redundant in the control of acute and persistent mCMV replication within mucosal and non-mucosal tissues

Nature, Democracy, and Sustainable Urban Transformations

Nature-based solutions (NBS) are proposed as a comprehensive approach to addressing a wide range of social, economic, and ecological problems in cities, featuring centrally in international policy as well as in many national and sub-national discourses. There is hope that NBS can address a wide range of societal challenges whilst also ameliorating the crisis of confidence in democracy, focusing on tailored solutions that are “co-produced” and “co-designed” with the communities who will benefit from them. NBS also offer a new way to frame urban greening efforts; one that is economically efficient and politically palatable. This chapter explores two key promises of NBS to achieve sustainable urban transformations: 1) that they offer democratic solutions to sustainability crises in urban areas, and 2) that NBS interventions offer innovative solutions to these crises. In doing so, the chapter reveals a mismatch between the ways NBS are framed as potential solutions to both material and existential sustainability challenges, and the reality of how NBS are implemented in practice. Their promise as a means of addressing environmental and socio-economic transformation is discussed in general and with respect to a particular case study, Urban GreenUP. The ways in which NBS are seen as technical solutions with measurable physical impacts, rather than as a new way to plan and develop cities, is found to stultify progress in using NBS to address society’s greatest challenges. Ultimately, this analysis finds that the transformative potential of NBS requires that cities be treated not just as living laboratories where new ideas can be tested, but that these new ideas need to be more than engineering advancements or novel demonstration projects. A more ambitious scope for NBS implementation would push the boundaries of how decisions are made, require a re-consideration of patterns of development, and significantly increase the scale of greening interventions

Rethinking Urban Nature: The Rise and Value of Nature-Based Solutions (NBS) in Europe

Nature-Based Solutions (NBS) have been proposed by the European Union as the most contemporary approach to delivering resilient cities in Europe. Through official guidance and funded projects, the Horizon 2020 programme, the EU has positioned nature at the centre of landscape and urban planning debates. However, there remains a scepticism regarding whether the support of NBS as an alternative to green infrastructure (GI) planning is meaningful and appropriate or damaging to existing practices. Furthermore, the framing of NBS does not, to date, extend the conceptual, practical or political parameters of ‘green space’ planning beyond terminological changes. Its most significant contribution to urban planning is the emphasis it places on urban ecology as a foundational principle of all development. To assess the added value of NBS in the planning and management of urban landscapes the paper reflects on the academic discussions surrounding the approach. This examines how NBS are being used to shape support for investment in urban nature but also argues that it potentially creates a schism between advocates of existing green space terminology and approaches. It concludes by setting the parameters for further analysis of how NBS are being, and may be used, going forward to socio-economic and ecological agendas in the EU

Novel Solutions or Rebranded Approaches: Evaluating the use of Nature-Based Solutions (NBS) in Europe

The Nature-Based Solutions (NBS) concept is the most recent entry to discussions around how “nature” can be mobilized to render urban areas more resilient to the threat of climate change. The concept has been championed by the European Commission (EC) as a tool that can transform contemporary environmental, social and economic challenges into opportunities for innovation, bolstering Europe's position as a leader in climate change mitigation and adaptation. With its current research and innovation programme—Horizon 2020—the EC looks to position itself as the global NBS frontrunner, providing funding to cities to act as NBS demonstrator projects across the continent. These are expected to provide best-practice examples that can be replicated globally. This paper focuses on three Horizon 2020-funded NBS demonstrator projects: Connecting Nature, URBAN GreenUP and Grow Green, each of which brings together a suite of urban partners from both within and outside the European Union (EU). It examines the internal “politics” i.e., the aims and internal governance and implementation issues associated with these projects, and analyses how partners perceive the NBS concept. To engage with these aims, interviews were conducted with a diverse set of NBS “practitioners” working within the three projects. Analysis showed that the projects aim to influence climate-change resilient and sustainable urbanism through the process of retrofitting cities with small-scale green and blue interventions, as well as help the EU secure stronger diplomatic relations with neighboring non-EU countries and key international trade partners. It also illustrated that for many project partners, NBS is perceived to be a novel concept, because it re-frames pre-existing terms such as Green and Blue Infrastructure (GBI) and Ecosystem Services (ES) in a way that makes principles of urban greening more understandable to lay audiences and more politically palatable for urban governments. However, partners also warn that this framing of NBS has led to a narrow and idealized representation of nature; one that simultaneously undervalues biodiversity and oversells the capacity of natural processes to provide “solutions” to urban climate vulnerability and broader patterns of unsustainable urbanism.</jats:p

Randomised controlled trial. Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis:Trial design and protocol (CONSTRUCT)

INTRODUCTION: Many patients with ulcerative colitis (UC) present with acute exacerbations needing hospital admission. Treatment includes intravenous steroids but up to 40% of patients do not respond and require emergency colectomy. Mortality following emergency colectomy has fallen, but 10% of patients still die within 3 months of surgery. Infliximab and ciclosporin, both immunosuppressive drugs, offer hope for treating steroid-resistant UC as there is evidence of their short-term effectiveness. As there is little long-term evidence, this pragmatic randomised trial, known as Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis: a Trial (CONSTRUCT), aims to compare the clinical and cost-effectiveness of infliximab and ciclosporin for steroid-resistant UC.METHODS AND ANALYSIS: Between May 2010 and February 2013, 52 UK centres recruited 270 patients admitted with acute severe UC who failed to respond to intravenous steroids but did not need surgery. We allocated them at random in equal proportions between infliximab and ciclosporin.The primary clinical outcome measure is quality-adjusted survival, that is survival weighted by Crohn's and Colitis Questionnaire (CCQ) participants' scores, analysed by Cox regression. Secondary outcome measures include: the CCQ-an extension of the validated but community-focused UK Inflammatory Bowel Disease Questionnaire (IBDQ) to include patients with acute severe colitis and stoma; two general quality of life measures-EQ-5D and SF-12; mortality; survival weighted by EQ-5D; emergency and planned colectomies; readmissions; incidence of adverse events including malignancies, serious infections and renal disorders; disease activity; National Health Service (NHS) costs and patient-borne costs. Interviews investigate participants' views on therapies for acute severe UC and healthcare professionals' views on the two drugs and their administration.ETHICS AND DISSEMINATION: The Research Ethics Committee for Wales has given ethical approval (Ref. 08/MRE09/42); each participating Trust or Health Board has given NHS Reseach &amp; Development approval. We plan to present trial findings at international and national conferences and publish in high-impact peer-reviewed journals.</p

Observing the Evolution of the Universe

How did the universe evolve? The fine angular scale (l>1000) temperature and polarization anisotropies in the CMB are a Rosetta stone for understanding the evolution of the universe. Through detailed measurements one may address everything from the physics of the birth of the universe to the history of star formation and the process by which galaxies formed. One may in addition track the evolution of the dark energy and discover the net neutrino mass. We are at the dawn of a new era in which hundreds of square degrees of sky can be mapped with arcminute resolution and sensitivities measured in microKelvin. Acquiring these data requires the use of special purpose telescopes such as the Atacama Cosmology Telescope (ACT), located in Chile, and the South Pole Telescope (SPT). These new telescopes are outfitted with a new generation of custom mm-wave kilo-pixel arrays. Additional instruments are in the planning stages.Comment: Science White Paper submitted to the US Astro2010 Decadal Survey. Full list of 177 author available at http://cmbpol.uchicago.ed