181 research outputs found
Evaluasi Padang Penggembalaan Alami Maronggela Di Kabupaten Ngada Provinsi Nusa Tenggara Timur
Evaluasi terhadap padang penggembalaan alami untuk memperbaiki kualitas hijauan merupakan salah satustrategi penting dalam peningkatan produksi ternak ruminansia. Penelitian ini bertujuan untuk menyediakandatabase tentang kondisi padang penggembalaan serta pengelolaan padang penggembalaan yang baik di KabupatenNgada. Kabupateng Ngada merupakan daerah yang sangat potensial bagi pengembangan ternak sapi karenamemiliki padang penggembalaan yang luas. Penelitian dilakukan di padang penggembalaan alami MaronggelaKabupaten Ngada, Provinsi Nusa Tenggara Timur, yang berlangsung selama 2 musim, yaitu pada akhir musimhujan (bulan Maret) dan akhir musim kemarau (bulan Oktober). Peubah yang diamati pada penelitian ini adalahkomposisi botani dan kualitas hijauan. Padang penggembalaan alami Maronggela didominasi oleh hijauan jenisImperata cylindrica dan Themeda aguens, produksi dan kualitas hijauan tertinggi di akhir musim hujan, sertaproduksi dan kualitas terendah di akhir musim kemarau. Daya tampung padang penggembalaan alami Maronggeladalam satu tahun adalah 1,5 satuan ternak.
Kata kunci: database, padang pengembalaan, sap
Kranc: a Mathematica application to generate numerical codes for tensorial evolution equations
We present a suite of Mathematica-based computer-algebra packages, termed
"Kranc", which comprise a toolbox to convert (tensorial) systems of partial
differential evolution equations to parallelized C or Fortran code. Kranc can
be used as a "rapid prototyping" system for physicists or mathematicians
handling very complicated systems of partial differential equations, but
through integration into the Cactus computational toolkit we can also produce
efficient parallelized production codes. Our work is motivated by the field of
numerical relativity, where Kranc is used as a research tool by the authors. In
this paper we describe the design and implementation of both the Mathematica
packages and the resulting code, we discuss some example applications, and
provide results on the performance of an example numerical code for the
Einstein equations.Comment: 24 pages, 1 figure. Corresponds to journal versio
Searching for the Kuhnian moment : the Black-Scholes-Merton formula and the evolution of modern finance theory
The Black-Scholes-Merton formula has been put to widespread use by options traders because it provides a means of calculating the theoretically 'correct' price of stock options. Traders can therefore see whether the market price of stock options undervalues or overvalues them compared with their hypothetical Black-Scholes-Merton price, before choosing to buy or sell options accordingly. As a consequence of this close relationship between options pricing theory and options pricing practice, a strong performativity loop was activated, whereby market prices quickly converged on the hypothetical Black-Scholes-Merton prices following the dissemination of the formula. The theory has therefore had significant real-world effects, but how should we characterize the initial instinct to derive the theory from a philosophy of science perspective? The two books under review suggest that a Kuhnian reading of the advancement of scientific knowledge might well be the most appropriate. But, on closer inspection, it becomes clear that the publication of the Black-Scholes-Merton formula should not be seen as a Kuhnian moment with paradigm-shaping attributes. It is shown that, at most, the formula acts as an important exemplar which, via its use in the training of options pricing theorists and options pricing practitioners, reinforces the entrenchment of finance theory within the orthodox economics worldview
Seasonal evolution of Aleutian low pressure systems: Implications for the North Pacific subpolar circulation
The seasonal change in the development of Aleutian low pressure systems from early fall to early winter is analyzed using a combination of meteorological reanalysis fields, satellite sea surface temperature (SST) data, and satellite wind data. The time period of the study is September–December 2002, although results are shown to be representative of the long-term climatology. Characteristics of the storms were documented as they progressed across the North Pacific, including their path, central pressure, deepening rate, and speed of translation. Clear patterns emerged. Storms tended to deepen in two distinct geographical locations—the Gulf of Alaska in early fall and the western North Pacific in late fall. In the Gulf of Alaska, a quasi-permanent “notch” in the SST distribution is argued to be of significance. The signature of the notch is imprinted in the atmosphere, resulting in a region of enhanced cyclonic potential vorticity in the lower troposphere that is conducive for storm development. Later in the season, as winter approaches and the Sea of Okhotsk becomes partially ice covered and cold, the air emanating from the Asian continent leads to enhanced baroclinicity in the region south of Kamchatka. This corresponds to enhanced storm cyclogenesis in that region. Consequently, there is a seasonal westward migration of the dominant lobe of the Aleutian low. The impact of the wind stress curl pattern resulting from these two regions of storm development on the oceanic circulation is investigated using historical hydrography. It is argued that the seasonal bimodal input of cyclonic vorticity from the wind may be partly responsible for the two distinct North Pacific subarctic gyres
Electronic Commerce Fraud: Towards an Understanding of the Phenomenon
The objective of this paper is to determine the factors that contribute to electronic commerce fraud. We present a model that identifies five causes: the incentives of criminals, the characteristics of victims, the role of technology, the role of enforcement, and system related factors. The Internet has lowered the barriers to entry for criminal enterprises. Victims are unable to determine which sites are real and which ones are fraudulent and lack of reporting further facilitates this type of crime. The lack of enforcement, resulting from inadequate resources and laws, contributes to the lowering of entry barriers to fraudulent businesses. An analysis of FTC cases shows that most crimes are not technologically sophisticated and that greater awareness and experience with this type of schemes people will avoid being victimized
Leukotriene antagonists as first-line or add-on asthma controller therapy
Most randomized trials of treatment for asthma study highly selected patients under idealized conditions. METHODS: We conducted two parallel, multicenter, pragmatic trials to evaluate the real-world effectiveness of a leukotriene-receptor antagonist (LTRA) as compared with either an inhaled glucocorticoid for first-line asthma-controller therapy or a long-acting beta(2)-agonist (LABA) as add-on therapy in patients already receiving inhaled glucocorticoid therapy. Eligible primary care patients 12 to 80 years of age had impaired asthma-related quality of life (Mini Asthma Quality of Life Questionnaire [MiniAQLQ] score =6) or inadequate asthma control (Asthma Control Questionnaire [ACQ] score =1). We randomly assigned patients to 2 years of open-label therapy, under the care of their usual physician, with LTRA (148 patients) or an inhaled glucocorticoid (158 patients) in the first-line controller therapy trial and LTRA (170 patients) or LABA (182 patients) added to an inhaled glucocorticoid in the add-on therapy trial. RESULTS: Mean MiniAQLQ scores increased by 0.8 to 1.0 point over a period of 2 years in both trials. At 2 months, differences in the MiniAQLQ scores between the two treatment groups met our definition of equivalence (95% confidence interval [CI] for an adjusted mean difference, -0.3 to 0.3). At 2 years, mean MiniAQLQ scores approached equivalence, with an adjusted mean difference between treatment groups of -0.11 (95% CI, -0.35 to 0.13) in the first-line controller therapy trial and of -0.11 (95% CI, -0.32 to 0.11) in the add-on therapy trial. Exacerbation rates and ACQ scores did not differ significantly between the two groups. CONCLUSIONS: Study results at 2 months suggest that LTRA was equivalent to an inhaled glucocorticoid as first-line controller therapy and to LABA as add-on therapy for diverse primary care patients. Equivalence was not proved at 2 years. The interpretation of results of pragmatic research may be limited by the crossover between treatment groups and lack of a placebo group
Evolutionary Proteomics: Empowering Tandem Mass Spectrometry and Bioinformatics Tools for the Study of Evolution
(-)-Epigallocatechin-3-gallate (EGCG) maintains k-casein in its pre-fibrillar state without redirecting its aggregation pathway
The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer\u27s, Parkinson\u27s and Huntington\u27s diseases, respectively. EGCG redirects the aggregation of these polypeptides to a disordered off-folding pathway that results in the formation of non-toxic amorphous aggregates. whether this anti-fibril activity is specific to these disease-related target proteins or ismore generic remains to be established. In addition, the mechanism by which EGCG exerts its effects, as with all anti-amyloidogenic polyphenols, remains unclear. To address these aspects, we have investigated the ability of EGCG to inhibit amyloidogenesis of the generic model fibril-forming protein RCMkappa-CN (reduced and carboxymethylated kappa-casein) and thereby protect pheochromocytoma-12 cells from RCMkappa-CN amyloid-induced toxicity. We found that EGCG potently inhibits in vitro fibril formation byRCMkappa-CN [the IC50 for 50 uM RCMkappa-CN is 1 uM]. Biophysical studies reveal that EGCG prevents RCMkappa-CN fibril formation by stabilising RCMkappa-CN in its nativelike state rather than by redirecting its aggregation to the disordered, amorphous aggregation pathway. Thus, while it appears that EGCG is a generic inhibitor of amyloid-fibril formation, the mechanism by which it achieves this inhibition is specific to the target fibril-forming polypeptide. It is proposed that EGCG is directed to the amyloidogenic sheet-turn-sheet motif of monomeric RCMkappa-CN with high affinity by strong non-specific hydrophobic associations. Additional non-covalent pi-pi stacking interactions between the polyphenolic and aromatic residues common to the amyloidogenic sequence are also implicated
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