Nanoseismic monitoring for detection of rockfalls. Experiments in quarry areas

Le frane per crollo da ammassi rocciosi fratturati sono tra i processi di instabilità gravitativa che più frequentemente interessano opere antropiche quali tagli su versanti naturali o artificiali, pareti di cava, trincee stradali, autostradali o ferroviarie, sia per ciò che attiene le aree di distacco che per quelle di accumulo. Nell’ambito dell’applicazione di sistemi di early warning per la gestione del rischio geologico legato a queste tipologie di frana, una sperimentazione della tecnica del monitoraggio nanosismometrico è stata effettuata presso due siti estrattivi non più in attività: le “Pirrere” della Baia di Cala Rossa sull’isola di Favignana (Trapani), in Sicilia, e la cava dismessa di Acuto (Frosinone), in Italia Centrale. Il monitoraggio nanosismometrico è una tecnica di indagine che consente di individuare e localizzare deboli eventi sismici, fino a magnitudo locale (ML) nell’ordine di -3, attraverso l’impiego di quattro sensori sismometrici disposti secondo una specifica geometria di array detta SNS (Seismic Navigation System). Nel presente lavoro, mediante il software NanoseismicSuite sono stati analizzati 73 eventi di crollo indotti artificialmente attraverso la caduta controllata di blocchi di roccia nei due siti estrattivi abbandonati; sono stati lanciati, simulando fenomeni di rockfalls, rispettivamente 47 blocchi di roccia nella cava di Acuto e 26 eventi in quattro diverse cave a cielo aperto presenti nel settore occidentale di Cala Rossa. Tali eventi, avendo punto epicentrale noto, hanno permesso di determinare il miglior modello di sottosuolo in termini di valori di velocità delle onde P ed S attraverso un’operazione di back analysis. L’analisi è stata, infatti, effettuata variando i valori di velocità e scegliendo quelli relativi all’epicentro teorico ottenuto dall’analisi dell’evento che fosse il più vicino possibile al punto reale di impatto del blocco di roccia. Al fine di valutare la sensibilità della geometria dell’array SNS e l’influenza del sito di installazione sulla capacità di individuare e localizzare gli eventi, le sperimentazioni sono state condotte sia variando il raggio di apertura che la zona di installazione degli array: presso Acuto le acquisizioni di segnale sono state condotte prima con un array SNS con apertura di 20 m e successivamente con un array di apertura 10 m, mentre presso Cala Rossa l’array è stato installato alternativamente all’aperto in un’area di plateau roccioso ed in una galleria facente parte dell’area di cava abbandonata. Analizzando i dati si è ottenuta una precisione dell’ubicazione epicentrale compresa tra il 10 ed il 22% della distanza che intercorre tra la sorgente e l’array nanosismometrico. Il miglior modello di sottosuolo ottenuto per entrambi i casi di studio è risultato avere una velocità delle onde P pari a 900 m/s ed un rapporto VP/VS pari a 1.73, valori in accordo con le condizioni di intenso stato di fratturazione delle rocce carbonatiche affioranti nelle due zone di cava. Per gli eventi di crollo indotti la magnitudo ML è risultata essere compresa tra -2.8 e -1.3; considerando l’energia sviluppata dall’impatto, legata alla massa del blocco ed all’altezza e alla velocità di caduta, non è stato possibile definire una relazione tra magnitudo ed energia, probabilmente a causa delle differenti caratteristiche del punto di impatto dei diversi blocchi. In generale, si è osservato che la precisione di ubicazione degli eventi, in termini di azimuth e distanza dal reale epicentro, è risultata paragonabile sia variando l’apertura dell’array che variando il sito di installazione. Per il sito sperimentale di Acuto, il processo di picking manuale del tempo di primo arrivo delle onde P è risultato essere più affidabile nel caso di array con apertura pari a 10 m. La sperimentazione effettuata a Cala Rossa ha permesso, invece, di osservare una migliore capacità di individuazione degli eventi nelle tracce relative all’array posizionato in galleria a causa della minore rumorosità di base del sito di installazione. Tra le registrazioni sismometriche sono state identificate varie tipologie di segnali, oltre a quelli generati dal lancio dei blocchi, alcune riconducibili ad eventi naturali di crollo altre a deboli terremoti. L’analisi dei segnali riferibili alla prima tipologia di eventi naturali, effettuata tenendo in considerazione i modelli di sottosuolo precedentemente calibrati, ha portato all’identificazione in ambedue i siti di aree aventi maggiore suscettibilità a frane per crollo. In definitiva, si può ritenere che i risultati ottenuti in questo studio siano incoraggianti rispetto all’efficacia della tecnica di monitoraggio nanosismometrico nell’individuazione e nell’ubicazione di fenomeni di crollo in roccia e portano a ritenere questa tecnica potenzialmente applicabile in aree in cui tali eventi possono interferire con infrastrutture antropiche.In the frame of early warning and risk mitigation studies for landslide processes involving rock masses, two quarry areas (Cala Rossa Bay in Sicily and Acuto in Central Italy) were monitored with SNS (Seismic Navigation System) arrays. In this study, 73 rockfalls were simulated by launches of rock blocks. This allowed to perform a back analysis for defining the best seismic velocity model of the subsoil half-space; the records related to each impact caused by the rock block launch were managed by the nanoseismic monitoring approach, varying the velocity model to obtain a theoretical epicentre as close as possible to the actual location of the impact point. In order to evaluate the sensibility of the SNS array, the results obtained by different array apertures and positions were compared in terms of azimuth and distance error with respect to the real epicentres. On the other hand, several natural rockfalls were detected; their analysis allowed to identify areas having higher susceptibility to rockfalls by using the previously calibrated subsoil half-space model. Further studies are required to better define the areas prone to rockfall generation in the considered test sites; nevertheless, the here obtained results show an encouraging perspective about the application of the nanoseismic monitoring with respect to vulnerable infrastructures in rockfall prone areas

Analysis of short-term blood pressure variability in pheochromocytoma/paraganglioma patients

Data on short-term blood pressure variability (BPV), which is a well-established cardiovascular prognostic tool, in pheochromocytoma and paraganglioma (PPGL) patients is still lack and conflicting. We retrospectively evaluated 23 PPGL patients referred to our unit from 2010 to 2019 to analyze 24 h ambulatory blood pressure monitoring (24-h ABPM)-derived markers of short-term BPV, before and after surgical treatment. PPGL diagnosis was assessed according to guidelines and confirmed by histologic examination. The 24-h ABPM-derived markers of short-term BPV included: circadian pressure rhythm; standard deviation (SD) and weighted SD (wSD) of 24-h, daytime, and night-time systolic and diastolic blood pressure (BP); average real variability (ARV) of 24-h, daytime, and night-time systolic and diastolic BP. 7 males and 16 females of 53 ± 18 years old were evaluated. After surgical resection of PPGL we found a significant decrease in 24-h systolic BP ARV (8.8 ± 1.6 vs. 7.6 ± 1.3 mmHg, p < 0.001), in 24-h diastolic BP ARV (7.5 ± 1.6 vs. 6.9 ± 1.4 mmHg, p = 0.031), and in wSD of 24-h diastolic BP (9.7 ± 2.0 vs 8.8 ± 2.1 mmHg, p = 0.050) comparing to baseline measurements. Moreover, baseline 24-h urinary metanephrines significantly correlated with wSD of both 24-h systolic and diastolic BP. Our study highlights as PPGL patients, after proper treatment, show a significant decrease in some short-term BPV markers, which might represent a further cardiovascular risk factor

A hardware spinal decoder

Spinal codes are a recently proposed capacity-achieving rateless code. While hardware encoding of spinal codes is straightforward, the design of an efficient, high-speed hardware decoder poses significant challenges. We present the first such decoder. By relaxing data dependencies inherent in the classic M-algorithm decoder, we obtain area and throughput competitive with 3GPP turbo codes as well as greatly reduced latency and complexity. The enabling architectural feature is a novel alpha-beta incremental approximate selection algorithm. We also present a method for obtaining hints which anticipate successful or failed decoding, permitting early termination and/or feedback-driven adaptation of the decoding parameters. We have validated our implementation in FPGA with on-air testing. Provisional hardware synthesis suggests that a near-capacity implementation of spinal codes can achieve a throughput of 12.5 Mbps in a 65 nm technology while using substantially less area than competitive 3GPP turbo code implementations.Irwin Mark Jacobs and Joan Klein Jacobs Presidential FellowshipIntel Corporation (Fellowship)Claude E. Shannon Research Assistantshi

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 90 minutes with consecutive reperfusion. 30 minutes after reperfusion, we performed pericardial irrigation with warm or cold saline for 60 minutes. Myocardial tissue analysis was performed one and four weeks after infarction. Therapeutic hypothermia induced a significant increase in autophagic flux, mitophagy, mitochondrial mass and function in the myocardium after infarction. Cell stress, apoptosis, inflammation as well as fibrosis were reduced, with significant preservation of systolic and diastolic function four weeks post infarction. We found similar biochemical changes in human samples undergoing open chest surgery under hypothermic conditions when compared to the warm. These results suggest that autophagic flux and mitophagy are important mechanisms implicated in cardiomyocyte recovery after myocardial infarction under hypothermic conditions. New therapeutic strategies targeting these pathways directly could lead to improvements in prevention of heart failure

Crowdsourced earthquake early warning

Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an M_w (moment magnitude) 7 earthquake on California’s Hayward fault, and real data from the M_w 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing

Functionally relevant white matter degradation in multiple sclerosis: a tract-based spatial meta-analysis

Purpose To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS). Materials and Methods By systematically searching online databases, tract-based spatial statistics studies were identified that compared fractional anisotropy (FA; a marker for WM integrity) in MS patients to healthy control subjects, correlated FA in MS patients with physical disability, or correlated FA in MS patients with cognitive performance. Voxelwise meta-analysis was performed by using the Signed Differential Mapping method for each comparison. Moderating effects of mean age, mean physical disability score, imager magnet strength, lesion load, and number of diffusion directions were assessed by means of meta-regression. Results Meta-analysis was performed on data from 495 patients and 253 control subjects across 12 studies. MS diagnosis was significantly associated with widespread lower tract FA (nine studies; largest cluster, 4379 voxels; z = 7.1; P < .001). Greater physical disability was significantly associated with lower FA in the right posterior cingulum, left callosal splenium, right inferior fronto-occipital fasciculus, and left fornix crus (six studies; 323 voxels; z = 1.7; P = .001). Impaired cognition was significantly associated with lower FA in the callosal genu, thalamus, right posterior cingulum, and fornix crus (seven studies; largest cluster, 980 voxels; z = 2.5; P < .001). Conclusion WM damage is widespread in MS with differential and only minimally overlapping distributions of low FA that relates to physical disability and cognitive impairment. The higher number of clusters of lower FA in relation to cognition and their higher z scores suggest that cerebral WM damage may have a greater relevance to cognitive dysfunction than physical disability in MS, and that low anterior callosal and thalamic FA have specific importance to cognitive status

What does the “Elephant-Equus” event mean today? Reflections on mammal dispersal events around the Pliocene-Pleistocene boundary and the flexible ambiguity of biochronology

The dispersal of primitive elephantines and monodactyl equids in Eurasia has long been regarded as representative of a substantial turnover in mammal faunas, denoting the spread of open environments linked to the onset of cold and dry conditions in the Northern Hemisphere. During the 1980s, this event was named the “Elephant-Equus event” and it was correlated with the Gauss-Matuyama reversal, today corresponding to the Pliocene-Pleistocene transition and the beginning of the Quaternary, dated at ~2.6 Ma. Therefore, the Elephant-Equus event became a concept of prominent biochronological and paleoecological significance, especially in western Europe. Yet, uncertainties surrounding the taxonomy and chronology of early “elephant” and “Equus”, as well as conceptual differences in adopting (or understanding) the Elephant-Equus event as an intercontinental dispersal event or as a stratigraphic datum, engendered ambiguity and debate. Here, we provide a succinct review of the Elephant-Equus event, considering separately the available evidence on the “elephant” and the “Equus”. Elephantines dispersed out of Africa during the Pliocene (Piacenzian). Their earliest calibrated occurrences from eastern Europe date at ~3.2 Ma and they are usually referred to Mammuthus rumanus, although the allocation of several samples to this species is tentative. Available dating constraints for other localities do not resolve whether the dispersal of Mammuthus was synchronous across Eurasia, but this possibility cannot be ruled out. The spread of Mammuthus was part of an intercontinental faunal exchange between Africa and Eurasia that occurred during the Piacenzian, but in this scenario, Mammuthus is quite unique in being the only genus of African origin dispersing to western Eurasia. The arrival of monodactyl equids from North America coincides with the Pliocene-Pleistocene transition, with several occurrences dated or calibrated at ~2.6 Ma and no compelling evidence prior to this age. In Europe, early monodactyl equids are often aligned to Equus livenzovensis, but the material from the type locality of this species is chronologically time-averaged and taxonomically heterogeneous, and western European samples are seldom abundant or informative. Regardless, this does not diminish the biochronological significance of the “Equus event”. Indeed, while the term “Elephant-Equus event” should no longer be used, as the appearance of elephantines in the European fossil record markedly precedes that of monodactyl equids, we endorse the use of the “Equus event” as a valid alternative to refer to the intercontinental dispersal event that characterizes the middle Villafranchian faunal turnover, epitomized by but not limited to monodactyl equids

Spinal codes

Spinal codes are a new class of rateless codes that enable wireless networks to cope with time-varying channel conditions in a natural way, without requiring any explicit bit rate selection. The key idea in the code is the sequential application of a pseudo-random hash function to the message bits to produce a sequence of coded symbols for transmission. This encoding ensures that two input messages that differ in even one bit lead to very different coded sequences after the point at which they differ, providing good resilience to noise and bit errors. To decode spinal codes, this paper develops an approximate maximum-likelihood decoder, called the bubble decoder, which runs in time polynomial in the message size and achieves the Shannon capacity over both additive white Gaussian noise (AWGN) and binary symmetric channel (BSC) models. Experimental results obtained from a software implementation of a linear-time decoder show that spinal codes achieve higher throughput than fixed-rate LDPC codes, rateless Raptor codes, and the layered rateless coding approach of Strider, across a range of channel conditions and message sizes. An early hardware prototype that can decode at 10 Mbits/s in FPGA demonstrates that spinal codes are a practical construction.Massachusetts Institute of Technology (Irwin and Joan Jacobs Presidential Fellowship)Massachusetts Institute of Technology (Claude E. Shannon Assistantship)Intel Corporation (Intel Fellowship