New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2’-bipyridine and 2,2’-dipyridylamine : synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

Peer reviewedPostprin

Metal complexes of saccharin and thiosaccharin as potential anticancer and antimicrobial agents

Acknowledgements The support provided by our universities (KTU, EOGU and UA) in accessing scientific databases (WOS, Scopus, SciFinder and CCDC) was greatly appreciated.Peer reviewe

Palladium(II) complexes of tridentate bis(benzazole) ligands: Structural, substitution kinetics, DNA interactions and cytotoxicity studies.

Reactions of 2,6-bis(benzimidazol-2-yl)pyridine (L1), 2,6-bis(benzoxazol-2-yl)pyridine (L2), and 2,6-bis(benzothiazol-2-yl)pyridine (L3) with [Pd(NCMe)2Cl2] in the presence of NaBF4 afforded the corresponding Pd(II) complexes, [Pd(L1)Cl]BF4, PdL1; [Pd(L2)Cl]BF4, PdL2; [Pd(L3)Cl]BF4, PdL3; respectively, while reaction of bis[(1H-benzimidazol-2-yl)methyl]amine (L4) with [Pd(NCMe)2Cl2] afforded complex [Pd(L4)Cl]Cl, PdL4. Characterisation of the complexes was accomplished using NMR, IR, MS, elemental analyses and single crystal X-ray crystallography. Ligand substitution kinetics of these complexes by biological nucleophiles thiourea (Tu), L-methionine (L-Met) and guanosine 5'-diphosphate disodium salt (5-GMP) were examined under pseudo-first order conditions. The reactivity of the complexes decreased in the order: PdL1 > PdL2 > PdL3 > PdL4, ascribed to electronic effects. Density functional theory (DFT) supported this trend. Studies of interaction of the Pd(II) complexes with calf thymus DNA (CT-DNA) revealed strong binding affinities via intercalative binding mode. Molecular docking studies established associative non-covalent interactions between the Pd complexes and DNA. The in vitro cytotoxic activities of PdL1-PdL4 were assessed in cancer cell lines HeLa and MRC5-SV2 and a normal cell line MRC-5, using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. PdL1 exhibited cytotoxic potency and selectivity against HeLa cell that was comparable to cisplatin's. Complex PdL1, unlike cisplatin, did not significantly induce caspase-dependent apoptosis

Synthesis, characterization and crystal structures of platinum(II) saccharinate complexes with 1,5-cyclooctadiene

Two new platinum(II) complexes, namely [PtCl(sac)(COD)] (1) and [Pt(sac)(2) (COD)] (2) (sac = saccharinate and COD = 1,5-cyclooctadiene), were synthesized and characterized by elemental analysis, IR, NMR, ESI-MS spectroscopic and thermal analysis (TG/DTA) methods. The platinum(II) complexes were prepared from the reaction of [PtCl2 (COD)] with Na(sac)center dot 2H(2)O. The addition of the sac ligand resulted in the replacement of 1 and 2 chlorido ligands in [PtCl2 (COD)] to yield 1 and 2, respectively. The structures of the complexes were determined by single crystal X-ray diffraction and showed a distorted square planar coordination geometry around platinum(II). COD acted as a p-donor ligand, while sac was N-coordinated in both complexes. The TG/DTA data indicated that both complexes were thermally stable up to 220 degrees C in air and their thermal decompositions yielded Pt as a final product. Complexes 1 and 2 were also designed as possible precursors to synthesize new mixed-ligand platinum(II) sac complexes in a one-pot reaction

Analysis of Celsia's Stock Market Performance in the Colombian Market 2023-2024

Este informe analizó el comportamiento bursátil Celsia S.A. en el mercado colombiano, entre 2023 – 2024 para aplicar los conocimientos adquiridos en el Diplomado de Gobierno Corporativo y Gestión de Inversiones a un caso real del sector energético. Para ello se utilizó una metodología de análisis mixto, que combinó herramientas del análisis fundamental y técnico, y utilizó como fuentes oficiales la Bolsa de Valores de Colombia (BVC), la Superintendencia Financiera de Colombia, informes corporativos de la empresa, plataformas financieras especializadas y la Comisión Reguladora de Energía y Gas (CREG). El análisis ha tenido en cuenta datos históricos de precios y la construcción de gráficos de la acción y el índice de fuerza relativa. Los resultados permitieron determinar que, a pesar de las consecuencias que el fenómeno El Niño dejó en 2023, la compañía mostró resistencia operativa al recuperar ingresos y márgenes en 2024. También la estrategia de adquisición de acciones generó una fuerte revalorización del título, por encima de un 50 %. Desde el estudio técnico se notaron signos claros de entrada y salida, como los cruces de medias móviles y áreas de sobrecompra y sobreventa que validaron la tendencia. Finalmente, se llegó a la conclusión de que la combinación del análisis fundamental y técnico dio una interpretación sólida del comportamiento accionario de Celsia, subrayando la necesidad de una visión integral del entorno económico, operativo y de mercado para la toma de decisiones de inversión informada y estratégica.Profesional en Negocios InternacionalesPregradoThis report analyzed the stock market performance of Celsia S.A. in the Colombian market between 2023 and 2024 in order to apply the knowledge acquired in the Corporate Governance and Investment Management diploma course to a real case in the energy sector. To this end, a mixed analysis methodology was used, combining fundamental and technical analysis tools, and using as official sources the Colombian Stock Exchange, the Financial Superintendency, corporate reports, specialized financial platforms, and the Energy and Gas Regulatory Commission (CREG). The analysis took into account historical price data and the construction of stock charts and the relative strength index. The results showed that, despite the consequences of the El Niño phenomenon in 2023, the company demonstrated operational resilience by recovering revenues and margins in 2024. The share acquisition strategy also generated a strong revaluation of the stock, above 50%. The technical study noted clear signs of entry and exit, such as moving average crossovers and overbought and oversold areas that validated the trend. Finally, it was concluded that the combination of financial and technical analysis provided a solid interpretation of Celsia's stock performance, underscoring the need for a comprehensive view of the economic, operational, and market environment for informed and strategic investment decisions

Correction: Zn(<scp>ii</scp>), Cd(<scp>ii</scp>) and Hg(<scp>ii</scp>) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell lines <i>via</i> ROS-induced apoptosis

Correction for ‘Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell lines via ROS-induced apoptosis’ by Ceyda Icsel et al., Dalton Trans., 2020, 49, 7842–7851, DOI: 10.1039/D0DT01535K.</p