User-centric QoE-driven vertical handover framework in heterogeneous wireless networks

© 2016 IEEE. With advances in wireless technology and the increase in popularity of mobile devices, more and more people now rely on mobile devices for multimedia services (such as video streaming and video calls). A mobile device can be connected and roamed to different networks in heterogeneous wireless networks. The Media Independent Handover (MIH) framework is designed by the IEEE 802.21 group to support seamless vertical handover between different networks. However, how to select an appropriate network from available ones and when to execute the handover remain the key challenges in MIH. This paper proposes a user-centric QoE-driven vertical handover (VHO) framework, based on MIH, which aims to maintain acceptable QoE of different mobile application services and to select an appropriate network based on users' preferences (e.g. on cost). Further a user-centric QoE-driven algorithm is implemented in the proposed framework. Its performance is evaluated and compared with two other VHO algorithms based on Network Simulator 2 (NS2) for video streaming services over heterogeneous networks. The preliminary results show that the proposed algorithm can maintain better QoE and at the same time, take into account user's preference on cost when compared with the other two algorithms

Complexity Measures for Quantifying Changes in Electroencephalogram in Alzheimer's Disease

Alzheimer’s disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the early stages would be useful for early diagnosis of AD, but this would involve dealing with large numbers of people because up to 50% of dementia sufferers do not receive formal diagnosis. Thus, there is a need for accurate, low-cost, and easy to use biomarkers that could be used to detect AD in its early stages. Potentially, electroencephalogram (EEG) based biomarkers can play a vital role in early diagnosis of AD as they can fulfill these needs. This is a cross-sectional study that aims to demonstrate the usefulness of EEG complexity measures in early AD diagnosis. We have focused on the three complexity methods which have shown the greatest promise in the detection of AD, Tsallis entropy (TsEn), Higuchi Fractal Dimension (HFD), and Lempel-Ziv complexity (LZC) methods. Unlike previous approaches, in this study, the complexity measures are derived from EEG frequency bands (instead of the entire EEG) as EEG activities have significant association with AD and this has led to enhanced performance. The results show that AD patients have significantly lower TsEn, HFD, and LZC values for specific EEG frequency bands and for specific EEG channels and that this information can be used to detect AD with a sensitivity and specificity of more than 90%

A Novel QoE-Centric SDN-Based Multipath Routing Approach for Multimedia Services over 5G Networks

© 2018 IEEE. The explosion of enhanced applications such as live video streaming, video gaming and Virtual Reality calls for efforts to optimize transport protocols to manage the increasing amount of data traffic on future 5G networks. Through bandwidth aggregation over multiple paths, the Multi-Path Transmission Control Protocol (MPTCP) can enhance the performance of network applications. MPTCP can split a large multimedia flow into subflows and apply a congestion control mechanism on each subflow. Segment Routing (SR), a promising source routing approach, has emerged to provide advanced packet forwarding over 5G networks. In this paper, we explore the utilization of MPTCP and SR in SDN-based networks to improve network resources utilization and end- user's QoE for delivering multimedia services over 5G networks. We propose a novel QoE-aware, SDN- based MPTCP/SR approach for service delivery. In order to demonstrate the feasibility of our approach, we implemented an intelligent QoE- centric Multipath Routing Algorithm (QoMRA) on an SDN source routing platform using Mininet and POX controller. We carried out experiments on Dynamic Adaptive video Steaming over HTTP (DASH) applications over various network conditions. The preliminary results show that, our QoE-aware SDN- based MPTCP/SR scheme performs better compared to the conventional TCP approach in terms of throughput, link utilization and the end-user's QoE

Discovery of Novel Biomarkers for Alzheimer's Disease from Blood

Blood-based biomarkers for Alzheimer’s disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (&gt;87%), specificity (&gt;91%), and accuracy (&gt;89%).</jats:p

Medication decision-making for patients with renal insufficiency in inpatient and outpatient care at a US Veterans Affairs Medical Centre: a qualitative, cognitive task analysis.

BackgroundMany studies identify factors that contribute to renal prescribing errors, but few examine how healthcare professionals (HCPs) detect and recover from an error or potential patient safety concern. Knowledge of this information could inform advanced error detection systems and decision support tools that help prevent prescribing errors.ObjectiveTo examine the cognitive strategies that HCPs used to recognise and manage medication-related problems for patients with renal insufficiency.DesignHCPs submitted documentation about medication-related incidents. We then conducted cognitive task analysis interviews. Qualitative data were analysed inductively.SettingInpatient and outpatient facilities at a major US Veterans Affairs Medical Centre.ParticipantsPhysicians, nurses and pharmacists who took action to prevent or resolve a renal-drug problem in patients with renal insufficiency.OutcomesEmergent themes from interviews, as related to recognition of renal-drug problems and decision-making processes.ResultsWe interviewed 20 HCPs. Results yielded a descriptive model of the decision-making process, comprised of three main stages: detect, gather information and act. These stages often followed a cyclical path due largely to the gradual decline of patients' renal function. Most HCPs relied on being vigilant to detect patients' renal-drug problems rather than relying on systems to detect unanticipated cues. At each stage, HCPs relied on different cognitive cues depending on medication type: for renally eliminated medications, HCPs focused on gathering renal dosing guidelines, while for nephrotoxic medications, HCPs investigated the need for particular medication therapy, and if warranted, safer alternatives.ConclusionsOur model is useful for trainees so they can gain familiarity with managing renal-drug problems. Based on findings, improvements are warranted for three aspects of healthcare systems: (1) supporting the cyclical nature of renal-drug problem management via longitudinal tracking mechanisms, (2) providing tools to alleviate HCPs' heavy reliance on vigilance and (3) supporting HCPs' different decision-making needs for renally eliminated versus nephrotoxic medications

INVESTIGATION OF OCULAR ARTEFACTS IN THE HUMAN EEG AND THEIR REMOVAL BY A MICROPROCESSOR-BASED INSTRUMENT

The Electroencephalogram (EEG) is widely used in clinical and psychological situations, but it is often seriously obscured by ocular artefacts (OAs) resulting from movements in the ocular system (eyeball, eyelids etc). 'The work described in this thesis is concerned with the problems of OAs in the human EEG, their removal both off-line and on-line, and the design and development of an on-line OA removal system, together with a critical review of the literature on the subject. The work of Jervis and his co-workers was extended to further study OAs, to obtain improved measures of the effectiveness of OA removal, and to find the most effective model for removing OA on-line. A number of criteria were devised to compare the performance of several models, including a more reliable pictorial method. It was found unnecessary to use the vertical and horizontal EOGs for both eyes (ie. four EOGs) in a removal model, as previously reported. This was shown to be due to strong correlation between the EOGs. It was shown that the assumption of uncorrelated error terms, implicit in present removal models, is invalid. To remedy this, the error terms were modelled as an autoregressive series. New on-line removal algorithms based on numerically stable factorization algorithms were developed. Compared to the present on-line methods the algorithms are superior, requiring no subjective manual adjustments, or the co-operation of subjects which cannot always be guarranteed. The algorithms were shown to give similar results to their off-line equivalents. A simpler algorithm based on the present on-line method is also proposed as an alternative, but may lead to a reduced performance. An important part of this research lay in the application of the results to the design and development of a new automatic OA removal system utilizing the algorithms described above.Department of Neurological Sciences, Freedom Fields Hospital, Plymout

Bayesian inference on compact binary inspiral gravitational radiation signals in interferometric data

Presented is a description of a Markov chain Monte Carlo (MCMC) parameter estimation routine for use with interferometric gravitational radiational data in searches for binary neutron star inspiral signals. Five parameters associated with the inspiral can be estimated, and summary statistics are produced. Advanced MCMC methods were implemented, including importance resampling and prior distributions based on detection probability, in order to increase the efficiency of the code. An example is presented from an application using realistic, albeit fictitious, data.Comment: submitted to Classical and Quantum Gravity. 14 pages, 5 figure

Welcome to Source Code for Biology and Medicine

This editorial introduces Source Code for Biology and Medicine, a new journal for publication of programming source code used in biology and medicine. Source Code for Biology and Medicine is an open access independent journal published by BioMed Central. We describe the journal aims, scope, benefits of open access, article processing charges, competing interests, content and article format, peer review policy and publication, and introduce the Editorial Board