Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk

名古屋大学Nagoya University博士(医学)著者名の「今」はひとやねの中がラではなくテdoctoral thesi

Identification of a novel HLA-A*24:02-restricted adenovirus serotype11-specific CD8+ T-cell epitope for adoptive immunotherapy

名古屋大学Nagoya University博士(医学)doctoral thesi

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury

アキタ フキズリ ガ タドッタ ゲンダイ キンセイ ニホン ニオケル インヨウズ タンジョウ ニ カンスル コウサツ ゲ ニ

論説(Article