Standar kompetensi lulusan (SKL) kursus dan pelatihan senam level II berbasis kerangka kualifikasi nasional Indonesia

LatarBelakang Indonesia memiliki berbagai keunggulan untuk mampu berkembang menjadi negara maju. Keanekaragaman sumber daya alam, flora dan fauna, kultur, penduduk serta letak geografis yang unik merupakan modal dasar yang kuat untuk melakukan pengembangan di berbagai sektor kehidupan yang pada saatnya dapat menciptakan daya saing yang unggul di dunia internasional. Dalam berbagai hal, kemampuan bersaing dalam sektor sumber daya manusia tidak hanya membutuhkan keunggulan dalam hal mutu akan tetapi juga memerlukan upaya-upaya pengenalan, pengakuan, serta penyetaraan kualifikasi pada bidang-bidang keilmuan dan keahlian yang relevan baiksecarabilateral,regionalmaupuninternasional

Standar kompetensi lulusan (SKL) kursus dan pelatihan senam level III berbasis kerangka kualifikasi nasional Indonesia

Latar Belakang Indonesia memiliki berbagai keunggulan untuk mampu berkembang menjadi negara maju. Keanekaragaman sumber daya alam, flora dan fauna, kultur, penduduk serta letak geografis yang unik merupakan modal dasar yang kuat untuk melakukan pengembangan di berbagai sektor kehidupan yang pada saatnya dapat menciptakan daya saing yang unggul di dunia internasional. Dalam berbagai hal, kemampuan bersaing dalam sektor sumber daya manusia tidak hanya membutuhkan keunggulan dalam hal mutu akan tetapi juga memerlukan upaya-upaya pengenalan, pengakuan, serta penyetaraan kualifikasi pada bidang-bidang keilmuan dan keahlian yang relevan baiksecarabilateral,regionalmaupuninternasional

Standar kompetensi lulusan (SKL) kursus dan pelatihan senam level IV berbasis kerangka kualifikasi nasional Indonesia

LatarBelakang Indonesia memiliki berbagai keunggulan untuk mampu berkembang menjadi negara maju. Keanekaragaman sumber daya alam, flora dan fauna, kultur, penduduk serta letak geografis yang unik merupakan modal dasar yang kuat untuk melakukan pengembangan di berbagai sektor kehidupan yang pada saatnya dapat menciptakan daya saing yang unggul di dunia internasional. Dalam berbagai hal, kemampuan bersaing dalam sektor sumber daya manusia tidak hanya membutuhkan keunggulan dalam hal mutu akan tetapi juga memerlukan upaya-upaya pengenalan, pengakuan, serta penyetaraan kualifikasi pada bidang-bidang keilmuan dan keahlian yang relevan baiksecarabilateral,regionalmaupuninternasional

Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma

BACKGROUND: The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatous transdifferentiation. METHODS: Genes that were differentially expressed between CC cell lines or tissues and cultured normal biliary epithelial (NBE) cells were identified using DNA microarray technology. Expressions were validated in human CC tissues and cells. RESULTS: Using unsupervised hierarchical clustering analysis of the cell line and tissue samples, we identified a set of 342 commonly regulated (>2-fold change) genes. Of these, 53, including tumor-related genes, were upregulated, and 289, including tumor suppressor genes, were downregulated (<0.5 fold change). Expression of SPP1, EFNB2, E2F2, IRX3, PTTG1, PPARγ, KRT17, UCHL1, IGFBP7 and SPARC proteins was immunohistochemically verified in human and hamster CC tissues. Additional unsupervised hierarchical clustering analysis of sarcomatoid CC cells compared to three adenocarcinomatous CC cell lines revealed 292 differentially upregulated genes (>4-fold change), and 267 differentially downregulated genes (<0.25 fold change). The expression of 12 proteins was validated in the CC cell lines by immunoblot analysis and immunohistochemical staining. Of the proteins analyzed, we found upregulation of the expression of the epithelial-mesenchymal transition (EMT)-related proteins VIM and TWIST1, and restoration of the methylation-silenced proteins LDHB, BNIP3, UCHL1, and NPTX2 during sarcomatoid transdifferentiation of CC. CONCLUSION: The deregulation of oncogenes, tumor suppressor genes, and methylation-related genes may be useful in identifying molecular targets for CC diagnosis and prognosis

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma

Human influenza A H5N1 in Indonesia: health care service-associated delays in treatment initiation.

BACKGROUND: Indonesia has had more recorded human cases of influenza A H5N1 than any other country, with one of the world's highest case fatality rates. Understanding barriers to treatment may help ensure life-saving influenza-specific treatment is provided early enough to meaningfully improve clinical outcomes. METHODS: Data for this observational study of humans infected with influenza A H5N1 were obtained primarily from Ministry of Health, Provincial and District Health Office clinical records. Data included time from symptom onset to presentation for medical care, source of medical care provided, influenza virology, time to initiation of influenza-specific treatment with antiviral drugs, and survival. RESULTS: Data on 124 human cases of virologically confirmed avian influenza were collected between September 2005 and December 2010, representing 73% of all reported Indonesia cases. The median time from health service presentation to antiviral drug initiation was 7.0 days. Time to viral testing was highly correlated with starting antiviral treatment (p < 0.0001). We found substantial variability in the time to viral testing (p = 0.04) by type of medical care provider. Antivirals were started promptly after diagnosis (median 0 days). CONCLUSIONS: Delays in the delivery of appropriate care to human cases of avian influenza H5N1 in Indonesia appear related to delays in diagnosis rather than presentation to health care settings. Either cases are not suspected of being H5N1 cases until nearly one week after presenting for medical care, or viral testing and/or antiviral treatment is not available where patients are presenting for care. Health system delays have increased since 2007

Warm‐air advection, air mass transformation and fog causes rapid ice melt

Direct observations during intense warm-air advection over the East Siberian Sea reveal a period of rapid sea-ice melt. A semi-stationary, high-pressure system north of the Bering Strait forced northward advection of warm, moist air from the continent. Air-mass transfor-mation over melting sea ice formed a strong, surface-based temperature inversion in which dense fog formed. This induced a positive net longwave radiation at the surface, while reduc-ing net solar radiation only marginally; the inversion also resulted in downward turbulent heat flux. The sum of these processes enhanced the surface energy flux by an average of ~15 W m-2 for a week. Satellite images before and after the episode show sea-ice concentrations decreasing from > 90% to ~50% over a large area affected by the air-mass transformation. We argue that this rapid melt was triggered by the increased heat flux from the atmosphere due to the warm-air advection

OGLE-2014-BLG-0962 and a Comparison of Galactic Model Priors to Microlensing Data

OGLE-2014-BLG-0962 (OB140962) is a stellar binary microlensing event that was well covered by observations from the Spitzer satellite as well as ground-based surveys. Modeling yields a unique physical solution: a mid-M+M-dwarf binary with M_(prim) = 0.20 ± 0.01 M☉ and M_(sec) = 0.16 ± 0.01 M☉, with projected separation of 2.0 ± 0.3 au. The lens is only D_(LS) = 0.41 ± 0.06 kpc in front of the source, making OB140962 a bulge lens and the most distant Spitzer binary lens to date. In contrast, because the Einstein radius (θ_E = 0.143 ± 0.007 mas) is unusually small, a standard Bayesian analysis, conducted in the absence of parallax information, would predict a brown dwarf binary. We compare the results of Bayesian analysis using two commonly used Galactic model priors to the measured values for a set of Spitzer lenses. We find all models tested predict lens properties consistent with the Spitzer data. Furthermore, we illustrate the methodology for probing the Galactic distribution of planets by comparing the cumulative distance distribution of the Spitzer two-body lenses to that of the Spitzer single lenses