HUBUNGAN EFIKASI DIRI TERHADAP DERAJAT DEPRESI PADA PASIEN OSTEOARTRITIS DI KLINIK AMANAH MEDIKA

Latar Belakang: Osteoartritis merupakan penyebab disabilitas tersering pada manusia lanjut usia dengan depresi sebagai salah satu komorbid. Depresi pada pasien dengan penyakit kronis dapat menurunkan kepatuhan terapi hingga memunculkan ide bunuh diri. Banyak studi yang mempelajari hubungan efikasi diri dengan depresi pada penyakit kronis. Rendahnya efikasi diri akan diikuti dengan tingginya derajat depresi. Studi ini bertujuan untuk mengetahui apakah terdapat hubungan antara efikasi diri tehadap derajat depresi pada pasien osteoartritis. Metode: Penelitian ini bersifat observasional analitik dengan pendekatan cross sectional. Pengambilan sampel dilakukan dengan teknik consecutive sampling. Tiga puluh pasien osteoartritis di Klinik Amanah Medika diwawancarai menggunakan kuesioner Arthritic-Self Efficacy Scale untuk mengukur skor efikasi diri dan short-form Geriatric Depression Scale untuk mengukur derajat depresi. Data yang didapat dianalisis menggunakan uji korelasi Pearson. Hasil: Dari hasil analisis data, terdapat hubungan efikasi diri dengan derajat depresi dengan nilai p = 0,000 yang berarti signifikan secara statistik, dengan kekuatan korelasi sangat kuat dan arah korelasi yang negatif (r = -0,801). Rendahnya skor efikasi diri diikuti dengan tingginya skor depresi. Simpulan: Terdapat hubungan antara efikasi diri terhadap derajat depresi pada pasien osteoartritis. Kata kunci: Osteoartritis, efikasi diri, depresi

A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds

The pallido-recipient thalamus transmits information from the basal ganglia to the cortex and is critical for motor initiation and learning. Thalamic activity is strongly inhibited by pallidal inputs from the basal ganglia, but the role of nonpallidal inputs, such as excitatory inputs from cortex, remains unclear. We simultaneously recorded from presynaptic pallidal axon terminals and postsynaptic thalamocortical neurons in a basal ganglia–recipient thalamic nucleus that is necessary for vocal variability and learning in zebra finches. We found that song-locked rate modulations in the thalamus could not be explained by pallidal inputs alone and persisted following pallidal lesion. Instead, thalamic activity was likely driven by inputs from a motor cortical nucleus that is also necessary for singing. These findings suggest a role for cortical inputs to the pallido-recipient thalamus in driving premotor signals that are important for exploratory behavior and learning.National Institutes of Health (U.S.) (Grant R01DC009183)National Institutes of Health (U.S.) (Grant K99NS067062)Damon Runyon Cancer Research Foundation (Postdoctoral Fellowship)Charles A. King Trust (Postdoctoral Fellowship

Polymyxin B-immobilized fiber column hemoperfusion mainly helps to constrict peripheral blood vessels in treatment for septic shock

BACKGROUND: Polymyxin B-immobilized fiber column hemoperfusion (PMX) has been reported to be effective for patients with septic shock. It remains unclear, however, how the efficacy of PMX varies according to the characteristics and underlying conditions of the patients treated. The objective of the present study was to clarify the factors that result in clinical efficacy of PMX treatment. METHODS: We retrospectively investigated 78 consecutive patients with severe sepsis or septic shock who underwent PMX treatment. We reviewed the demographic data, routine biochemistry, microbiological data, infection focus, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assessment (SOFA) score, change in mean arterial pressure (MAP), inotropic score, vasopressor dependency index, plasma levels of endotoxin and lactate, PaO(2)/F(I)O(2) ratio, and survival time. We also divided the patients into two groups for comparison, namely, those whose inotropic scores improved after PMX treatment (improvement group) and those whose inotropic scores did not improve (non-improvement group). RESULTS: The inotropic score and the vasopressor dependency index significantly decreased from 18.1 to 9.9 (p < 0.05) and from 0.27 to 0.14 (p < 0.05), respectively, after PMX treatment in the overall study population, while no significant change in the PaO(2)/F(I)O(2) ratio was observed (p = 0.96). The inotropic score at pre-PMX treatment was significantly higher in the improvement group than in the non-improvement group (p < 0.01). The improvement of the PaO(2)/F(I)O(2) ratio after PMX treatment was significant in the improvement group (p < 0.05). CONCLUSIONS: The improvement group’s inotropic score was higher, because of peripheral blood vessels dilatation and requirement for more catecholamines. Therefore, our study suggests that PMX treatment is particularly useful for improving hemodynamics in septic shock patients with excessively dilated peripheral blood vessels

Pulmonary Artery Leiomyosarcoma Diagnosed without Delay

A 63-year-old female presented with abnormal lung shadows but had, apart from this, few symptoms. Computed tomography (CT) revealed multiple nodules and blockage of the pulmonary artery. She was immediately diagnosed with pulmonary artery sarcoma based on a careful differential diagnosis and underwent surgery. Her tumor was pathologically diagnosed as leiomyosarcoma (i.e. intimal sarcoma). Pulmonary artery sarcoma can be easily confounded with thromboembolism in a clinical setting and some cases are diagnosed post mortem only. In our case, clinical prediction scores (Wells score, Geneva score, and revised Geneva score) for the pulmonary embolism showed low probability. Moreover, chest CT showed uncommon findings for pulmonary thromboembolism, as the nodules were too big for thrombi. Because surgical resection can provide the only hope of long-term survival in cases of pulmonary artery sarcoma, clinicians should consider this possibility in the differential diagnosis of pulmonary embolism. Clinical prediction scores and CT findings might help to reach the correct diagnosis of pulmonary artery sarcoma

Efficacy and safety of nintedanib in Japanese patients with progressive fibrosing interstitial lung diseases : Subgroup analysis of the randomised, double-blind, placebo-controlled, phase 3 INBUILD trial

Background: The efficacy of nintedanib in progressive fibrosing interstitial lung diseases (ILDs) was demonstrated in the randomised, double-blind, placebo-controlled INBUILD trial. This subgroup analysis evaluated the efficacy and safety of nintedanib in the Japanese population. Methods: Patients with progressive fibrosing ILDs (evaluated by physicians within 24 months of screening) were randomised (1:1) to twice-daily 150-mg nintedanib or placebo; treatment continued until the last patient completed 52 weeks. The primary endpoint was the annual rate of decline in forced vital capacity (FVC) over 52 weeks. Time-to-first acute ILD exacerbation or death and time-to-death up until the last patient had completed the week 52 visit were evaluated. This subgroup analysis included 108 Japanese patients. Results: The adjusted annual rates of FVC decline (mL/year) over 52 weeks for Japanese patients were −148.31 (nintedanib) and −240.36 (placebo), adjusted difference: 92.05 (95% CI: −10.69–194.80) and for non-Japanese patients were −67.41 (nintedanib) and −177.65 (placebo), adjusted difference: 110.24 (95% CI: 64.97–155.52). No heterogeneity in treatment effect between Japanese and non-Japanese subgroups was observed (treatment-by-subgroup interaction, p = 0.75). The risks of “acute exacerbation or death” (hazard ratio, 0.30 [95% CI: 0.10–0.91]) and mortality (hazard ratio, 0.54 [95% CI: 0.14–2.11]) in Japanese patients were numerically lower for nintedanib than placebo. There were no new or unexpected safety findings. Conclusions: In Japanese patients, nintedanib slowed ILD progression, evidenced by a reduction in the annual rate of decline in FVC vs placebo. The efficacy and safety of nintedanib in Japanese patients were consistent with the overall INBUILD population

KATERINGMAKSIATSAHABATMAHASISWA:Penyedia Makanan Sedap, Bergizi dan Sehat

Kurangnya lapangan kerja menyebabkan banyaknya pengangguran di Indonesia, salah satunya adalah ibu rumah tangga. Di sisi lain, sebagian warung makan di sekitar kampus UNS juga kurang menjaga kebersihannya. Selain itu, sebagian mahasiswa yang tinggal di rantau kurang peduli dengan kandungan gizi dan melalaikan gizi seimbang dari makanan yang dibeli di warung makan. Berdasarkan pertimbangan tersebut,penulis memilki gagasan menciptakan usaha penyedia makanan yang bersih dan sehat serta memperhatikan kandungan gizi dalam makanan untuk menyelesaikan masalah pola makan mahasiswa dan masalah pengangguran ibu rumah tangga. Katering Maksiat yang memberdayakan ibu rumah tangga Mertoudan RT 02 RW 09 Mojosongo Surakarta memilki visi melakukan inovasi untuk mengolah makanan yang inovatif dengan nilai gizi tinggi. Dalam penentuan target ditentukan target pasar dan target penjualan. Pemasaran produk dilakukan di lingkungan kampus Universitas Sebelas Maret. Strategi produk dilakukan dengan memaksimalkan produksi sepanjang pelaksanaan program dengan peningkatan produksi secara bertahap serta adanya bonus dosa. Strategi harga dilakukan dengan menerapkan harga layanan jasa dibawah harga katering umumnya. Promosi dilakukan secara mouth to mouth dan memanfaatkan media sosial. Kata Kunci: pengangguran, kebersihan makanan, gizi, Katering Maksia