Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants

© 2017 The Author(s). Background: Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact upon the validity of data for benchmarking purposes. Method: Data from all VLGA or VLBW infants admitted in the 3 Networks between 2008 and 2011 were used. Two-thirds of each network cohort was randomly selected to develop prediction models for mortality and composite adverse outcome (CAO: mortality or cerebral injuries, chronic lung disease, severe retinopathy or necrotizing enterocolitis) and the remaining for internal validation. Areas under the ROC curves (AUC) of the models were compared. Results: VLBW cohort (24,335 infants) had twice more SGA infants (20.4% vs. 9.3%) than the VLGA cohort (29,180 infants) and had a higher rate of CAO (36.5% vs. 32.6%). The two models had equal prediction power for mortality and CAO (AUC 0.83), and similarly for all other cross-cohort validations (AUC 0.81-0.85). Neither model performed well for the extremes of birth weight for gestation (<1500 g and ≥32 weeks, AUC 0.50-0.65; ≥1500 g and <32 weeks, AUC 0.60-0.62). Conclusion: There was no difference in prediction power for adverse outcome between cohorting VLGA or VLBW despite substantial bias in SGA population. Either cohorting practises are suitable for international benchmarking

Abstract TP155: Robotic Retraining of Finger Movements After Stroke

Background: Robots aid motor rehabilitation, but there has been limited attention to recovery of finger movements. This study evaluated robotic assistance during finger movement training. Functional MRI (fMRI) was acquired at baseline to understand predictors of treatment gains. Methods: Patients with chronic stroke underwent a baseline fMRI scan, alternating rest with affected-side finger movements similar to those made during robotic therapy. Next, subjects received therapy 3 hr/wk for 3 weeks using FINGER (Finger Individuating Grasp Exercise Robot), with which subjects moved their paretic index and middle fingers to play a musical game similar to GuitarHero. FINGER used an assistance-as-needed algorithm to facilitate completion of grasping movements, which increased sensory feedback without altering voluntary motor output. Participants were randomized to receive High Assistance (to insure 85% success) or Low Assistance (55% success). Results: 30 subjects (mean age 58 yr; baseline Fugl-Meyer 46 out of 66; 37 mo post-stroke) completed the study. Significant gains were found in the primary outcome measure, change in Box &amp; Blocks (B&amp;B) score (23 to 25.5, p&lt;0.0001). There was no difference between High and Low Assistance groups in the primary endpoint (p=0.65), though some secondary outcomes favored High Assistance. The fMRI scans found that greater treatment gains were associated with higher laterality index in primary sensory cortex, indicating greater boost in B&amp;B score over time with higher pretreatment balance of activation towards ipsilesional rather than contralesional sensory cortex; laterality index in primary motor cortex lacked predictive value. Conclusions: Significant motor gains were found with a robotic device that targets finger movements. Sensory factors appear key: treatment content emphasized augmented sensory feedback, and the hemispheric balance of fMRI activation within sensory but not motor cortex predicted treatment gains. Together these findings suggest Hebbian rules of sensorimotor cortex plasticity during finger robotic therapy after stroke. </jats:p

Robotic Assistance for Training Finger Movement Using a Hebbian Model: A Randomized Controlled Trial.

BackgroundRobots that physically assist movement are increasingly used in rehabilitation therapy after stroke, yet some studies suggest robotic assistance discourages effort and reduces motor learning.ObjectiveTo determine the therapeutic effects of high and low levels of robotic assistance during finger training.MethodsWe designed a protocol that varied the amount of robotic assistance while controlling the number, amplitude, and exerted effort of training movements. Participants (n = 30) with a chronic stroke and moderate hemiparesis (average Box and Blocks Test 32 ± 18 and upper extremity Fugl-Meyer score 46 ± 12) actively moved their index and middle fingers to targets to play a musical game similar to GuitarHero 3 h/wk for 3 weeks. The participants were randomized to receive high assistance (causing 82% success at hitting targets) or low assistance (55% success). Participants performed ~8000 movements during 9 training sessions.ResultsBoth groups improved significantly at the 1-month follow-up on functional and impairment-based motor outcomes, on depression scores, and on self-efficacy of hand function, with no difference between groups in the primary endpoint (change in Box and Blocks). High assistance boosted motivation, as well as secondary motor outcomes (Fugl-Meyer and Lateral Pinch Strength)-particularly for individuals with more severe finger motor deficits. Individuals with impaired finger proprioception at baseline benefited less from the training.ConclusionsRobot-assisted training can promote key psychological outcomes known to modulate motor learning and retention. Furthermore, the therapeutic effectiveness of robotic assistance appears to derive at least in part from proprioceptive stimulation, consistent with a Hebbian plasticity model

Finger strength, individuation, and their interaction: Relationship to hand function and corticospinal tract injury after stroke.

The goal of this study was to determine the relative contributions of finger weakness and reduced finger individuation to reduced hand function after stroke, and their association with corticospinal tract (CST) injury.We measured individuated and synergistic maximum voluntary contractions (MVCs) of the index and middle fingers, in both flexion and extension, of 26 individuals with a chronic stroke using a robotic exoskeleton. We quantified finger strength and individuation, and defined a novel metric that combines them - "multifinger capacity". We used stepwise linear regression to identify which measure best predicted hand function (Box and Blocks Test, Nine Hole Peg Test) and arm impairment (the Upper Extremity Fugl-Meyer Test).Compared to metrics of strength or individuation, capacity survived the stepwise regression as the strongest predictor of hand function and arm impairment. Capacity was also most strongly related to presence or absence of lesion overlap with the CST.Reduced strength and individuation combine to shrink the space of achievable finger torques, and it is the resulting size of this space - the multifinger capacity - that is of elevated importance for predicting loss of hand function.Multi-finger capacity may be an important target for rehabilitative hand training

Use of a robotic device to measure age-related decline in finger proprioception.

Age-related changes in proprioception are known to affect postural stability, yet the extent to which such changes affect the finger joints is poorly understood despite the importance of finger proprioception in the control of skilled hand movement. We quantified age-related changes in finger proprioception in 37 healthy young, middle-aged, and older adults using two robot-based tasks wherein participants' index and middle fingers were moved by an exoskeletal robot. The first task assessed finger position sense by asking participants to indicate when their index and middle fingers were directly overlapped during a passive crisscross movement; the second task assessed finger movement detection by asking participants to indicate the onset of passive finger movement. When these tasks were completed without vision, finger position sense errors were 48 % larger in older adults compared to young participants (p &lt; 0.05); proprioceptive reaction time was 78 % longer in older adults compared to young adults (p &lt; 0.01). When visual feedback was provided in addition to proprioception, these age-related differences were no longer apparent. No difference between dominant and non-dominant hand performance was found for either proprioception task. These findings demonstrate that finger proprioception is impaired in older adults, and visual feedback can be used to compensate for this deficit. The findings also support the feasibility and utility of the FINGER robot as a sensitive tool for detecting age-related decline in proprioception

Robotic Assistance for Training Finger Movement Using a Hebbian Model: A Randomized Controlled Trial.

BackgroundRobots that physically assist movement are increasingly used in rehabilitation therapy after stroke, yet some studies suggest robotic assistance discourages effort and reduces motor learning.ObjectiveTo determine the therapeutic effects of high and low levels of robotic assistance during finger training.MethodsWe designed a protocol that varied the amount of robotic assistance while controlling the number, amplitude, and exerted effort of training movements. Participants (n = 30) with a chronic stroke and moderate hemiparesis (average Box and Blocks Test 32 ± 18 and upper extremity Fugl-Meyer score 46 ± 12) actively moved their index and middle fingers to targets to play a musical game similar to GuitarHero 3 h/wk for 3 weeks. The participants were randomized to receive high assistance (causing 82% success at hitting targets) or low assistance (55% success). Participants performed ~8000 movements during 9 training sessions.ResultsBoth groups improved significantly at the 1-month follow-up on functional and impairment-based motor outcomes, on depression scores, and on self-efficacy of hand function, with no difference between groups in the primary endpoint (change in Box and Blocks). High assistance boosted motivation, as well as secondary motor outcomes (Fugl-Meyer and Lateral Pinch Strength)-particularly for individuals with more severe finger motor deficits. Individuals with impaired finger proprioception at baseline benefited less from the training.ConclusionsRobot-assisted training can promote key psychological outcomes known to modulate motor learning and retention. Furthermore, the therapeutic effectiveness of robotic assistance appears to derive at least in part from proprioceptive stimulation, consistent with a Hebbian plasticity model