The CHIME graduate programme in health informatics

In 1999 University College London inaugurated a programme of graduate part-time Health Informatics courses to support the UK National Health Service?s Information for Health strategy. The programme has attracted students from across the UK and abroad, with a diverse range of backgrounds and skills and has proved a challenging and rewarding experience for students and tutors alike. The modular programme aims to provide a thorough grounding in the theory and practice of Health Informatics and addresses important application areas. The guiding principle is that Health Informatics graduates need to understand computers and programming but that, since the majority are not going to become programmers, programming methods should not dominate the curriculum.In the taught phase of the programme students attend college for 3 days a month and complete an assignment each month, based on home study. Students may graduate with a certificate or diploma, or go on to tackle a dissertation leading to an MSc. Research projects have included a patient record system based on speech input, a mathematical model for illustrating to patients the risks associated with smoking, an analysis of Trust staff's preparedness for Information for Health and a patient information leaflet giving advice about drug related information on the Web. As we move towards our fifth intake of students, we are in the process of evaluating our programme and carrying out a follow up study of our graduates? subsequent career pathways

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

Objectives: CLEF is an MRC sponsored project in the E-Science programme that aims to establish methodologies and a technical infrastructure for the next generation of integrated clinical and bioscience research. Methods: The heart of the CLEF approach to this challenge is to design and develop a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies have been developed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. Results: This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows, pseudonymisation measures and additional monitoring policies that are currently being developed. Conclusion: Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

CLEF is an MRC sponsored project in the E-Science programme that aims to establish policies and infrastructure for the next generation of integrated clinical and bioscience research. One of the major goals of the project is to provide a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies are needed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows and pseudonymisation mechanisms that are currently being developed. Intended constraints and monitoring policies that will apply to research interrogation of the repository are also outlined. Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

Low-frequency QPO from the 11 Hz accreting pulsar in Terzan 5: not frame dragging

We report on 6 RXTE observations taken during the 2010 outburst of the 11 Hz accreting pulsar IGR J17480-2446 located in the globular cluster Terzan 5. During these observations we find power spectra which resemble those seen in Z-type high-luminosity neutron star low-mass X-ray binaries, with a quasi-periodic oscillation (QPO) in the 35-50 Hz range simultaneous with a kHz QPO and broad band noise. Using well known frequency-frequency correlations, we identify the 35-50 Hz QPOs as the horizontal branch oscillations (HBO), which were previously suggested to be due to Lense-Thirring precession. As IGR J17480-2446 spins more than an order of magnitude more slowly than any of the other neutron stars where these QPOs were found, this QPO can not be explained by frame dragging. By extension, this casts doubt on the Lense-Thirring precession model for other low-frequency QPOs in neutron-star and perhaps even black-hole systems.Comment: 6 pages, 5 figures, Accepted for publication in ApJ

Financial health indicators: an analysis of financial statement information to determine the financial health of DoD contractors

MBA Professional ReportPrior to awarding a contract, government contracting officers must be able to determine the financial health of prospective contractors. In fact, according to the Federal Acquisition Regulation (FAR) 9.104- 1(a), the very first general requirement to being considered a responsible prospective contractor is to show adequate financial resources to perform the contract or the ability to obtain financing. The purpose of this research is to identify a financial assessment framework that could assist DOD contracting officers with determining the financial health of potential DOD contractors. This research study may help DOD contracting officers determine the financial health of potential contractors prior to awarding a contract. The findings of this study provide a recommended framework that a contracting officer could follow in order to assess the financial health of a prospective contractor. The framework includes a ratio analysis using selected ratios compiled by this study, as well as a comparative analysis using industry average driven data. The framework also incorporates horizontal and vertical analyses, as well as bankruptcy and fraud analyses. The financial assessment framework created in this study is a comprehensive financial health assessment tool that can be utilized by DOD contracting officers.http://archive.org/details/financialhealthi1094551703Lieutenant Commander, United States NavyLieutenant, United States NavyLieutenant, United States NavyApproved for public release; distribution is unlimited

Wave interaction with a sea dike using a VOF finite-volume method

This paper represents a solver for numerical simulation of breaking waves, developed at Ghent University using an implicit cellstaggered VOF finite volume approach. The mathematical model is based on unsteady incompressible Navier-Stokes (NS) equations with a free surface. A flux-difference splitting approach with the MUSCL type (or the ENO scheme) and a central-difference scheme are applied for evaluation of the inviscid and viscous fluxes, respectively. A projection method is involved for coupling of the pressure and the velocity. A free surface is tracked with the VOF method, in which the approximate dynamic boundary conditions are implemented. In addition, second- and fourth-order artificial damping terms are introduced to the velocity normal to the cell face. A Sommerfeld radiation condition is implemented at the open boundary to dissipate the energy of outgoing waves. Moreover, cut-cell techniques are utilized for treatment of an arbitrary geometry. The solver can capture many physical phenomena during the interaction of waves with a dike, when a wave run-up and overtopping over an impermeable sea dike are performed in a numerical wave tank

Joining up health and bioinformatics: e-science meets e-health

CLEF (Co-operative Clinical e-Science Framework) is an MRC sponsored project in the e-Science programme that aims to establish methodologies and a technical infrastructure forthe next generation of integrated clinical and bioscience research. It is developing methodsfor managing and using pseudonymised repositories of the long-term patient histories whichcan be linked to genetic, genomic information or used to support patient care. CLEF concentrateson removing key barriers to managing such repositories ? ethical issues, informationcapture, integration of disparate sources into coherent ?chronicles? of events, userorientedmechanisms for querying and displaying the information, and compiling the requiredknowledge resources. This paper describes the overall information flow and technicalapproach designed to meet these aims within a Grid framework

Dynamic Analysis of Executables to Detect and Characterize Malware

It is needed to ensure the integrity of systems that process sensitive information and control many aspects of everyday life. We examine the use of machine learning algorithms to detect malware using the system calls generated by executables-alleviating attempts at obfuscation as the behavior is monitored rather than the bytes of an executable. We examine several machine learning techniques for detecting malware including random forests, deep learning techniques, and liquid state machines. The experiments examine the effects of concept drift on each algorithm to understand how well the algorithms generalize to novel malware samples by testing them on data that was collected after the training data. The results suggest that each of the examined machine learning algorithms is a viable solution to detect malware-achieving between 90% and 95% class-averaged accuracy (CAA). In real-world scenarios, the performance evaluation on an operational network may not match the performance achieved in training. Namely, the CAA may be about the same, but the values for precision and recall over the malware can change significantly. We structure experiments to highlight these caveats and offer insights into expected performance in operational environments. In addition, we use the induced models to gain a better understanding about what differentiates the malware samples from the goodware, which can further be used as a forensics tool to understand what the malware (or goodware) was doing to provide directions for investigation and remediation.Comment: 9 pages, 6 Tables, 4 Figure

The Invisible Thin Red Line

The aim of this paper is to argue that the adoption of an unrestricted principle of bivalence is compatible with a metaphysics that (i) denies that the future is real, (ii) adopts nomological indeterminism, and (iii) exploits a branching structure to provide a semantics for future contingent claims. To this end, we elaborate what we call Flow Fragmentalism, a view inspired by Kit Fine (2005)’s non-standard tense realism, according to which reality is divided up into maximally coherent collections of tensed facts. In this way, we show how to reconcile a genuinely A-theoretic branching-time model with the idea that there is a branch corresponding to the thin red line, that is, the branch that will turn out to be the actual future history of the world

Orally active antischistosomal early leads identified from the open access malaria box.

BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro activity against Plasmodium falciparum. Compounds were tested against schistosomula and adult Schistosoma mansoni in vitro. Based on in vitro performance, available pharmacokinetic profiles and toxicity data, selected compounds were investigated in vivo. PRINCIPAL FINDINGS: Promising antischistosomal activity (IC50: 1.4-9.5 µM) was observed for 34 compounds against schistosomula. Three compounds presented IC50 values between 0.8 and 1.3 µM against adult S. mansoni. Two promising early leads were identified, namely a N,N'-diarylurea and a 2,3-dianilinoquinoxaline. Treatment of S. mansoni infected mice with a single oral 400 mg/kg dose of these drugs resulted in significant worm burden reductions of 52.5% and 40.8%, respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry and therefore offer an excellent starting point for antischistosomal drug discovery and development