Emergency Hospital Admissions of Elderly Patients with Dementia: General Characteristics, Outcome, and Areas of Improvement at an Accident and Emergency Department

Aim: Age-related disorders, such as dementia, are relevant for healthcare services and health systems worldwide. The prevalence of dementia across European countries is estimated to exceed 7 %, and may rise over time. Those patients are at increased risk for hospital admission and prolonged hospitalization, and such care increases the cost for the healthcare system. Less is known regarding patients with dementia in Greece that visit the Accident and Emergency departments (A&E) in general hospitals. The present retrospective study aimed to address this issue. Subjects and methods: The sample of patients and the control group were traced in the A&E department of the University Hospital of Ioannina, Northwest Greece. The study sample consisted of 100 patients with dementia, aged > 65 years and 100 matched controls. The median age of patients with dementia was 85 years, for the control group 83 years, and 63 % were females. In most cases the diagnosis had been made by primary care physicians, and in of patients 21 % by neurologists/psychiatrists. Results: In both groups a median of 2 comorbidities was recorded, with hypertension, heart failure and dyslipidaemia being the most common. Fever and falls were the most common reasons for dementia patients visiting the A&E department. Infection was the most common diagnosis in dementia patients, whereas in 17 % of cases no diagnosis was made and no interventions were needed. The probability of admission after an A&E visit was significantly higher for the dementia group, whereas there were no differences regarding length of hospital stay between patients and controls. Conclusions: The results of the study are in line with international research and highlight the need for the establishment of a national register for patients with dementia, that would enable information exchange between primary and tertiary care and would enable proper diagnosis, management and discharge arrangements

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study

Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID.About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID

Cognitive impairment in COPD: should cognitive evaluation be part of respiratory assessment?

Cognitive impairment is highly prevalent in patients with COPD and demonstrates multiple detrimental effects on many aspects of patient state and therapeutic outcomes. It is attributed to several overlapping pathophysiological factors, with the most common being the low level of oxygen saturation due to respiratory insufficiency. Despite the impact of cognitive impairment on clinical outcomes, the screening for coexisting cognitive deficits which may interfere with the successful progress of respiratory treatment is yet neglected. There is a special consideration that cognitive deficits should be taken into account when developing respiratory therapy plans. Cognitively impaired patients are likely to require more support and have need of an individualised respiratory care plan which can also be beneficial for their cognitive deficits. Pulmonary rehabilitation as a multidisciplinary approach could be prioritised for COPD patients with cognitive impairment

Windsurfing: The Physiology of Athletic Performance and Training

The sport of windsurfing requires good physical condition and skills. Windsurfers use pumping for propulsion during sailing, a demanding endurance maneuver in which the athlete pulls the sail rhythmically so that it acts as a wing, thus providing the board with additional forward motion especially in light and moderate wind conditions. The physiological demands in windsurfing, however, can vary greatly as depend on weather conditions (wind velocity), the intensity – duration of the effort, and the type of sailboard. Several physiological determinants, nutrition, and training methods can influence the overall performance of windsurfers. This article provides an overview of windsurfing physiology including the physiological responses during race and the determinants of windsurfing performance, which are also related to different wind conditions. Additionally, it indicates training methods and nutritional information for competitive windsurfers

Mechanisms of Physical Activity Limitation in Chronic Lung Diseases

In chronic lung diseases physical activity limitation is multifactorial involving respiratory, hemodynamic, and peripheral muscle abnormalities. The mechanisms of limitation discussed in this paper relate to (i) the imbalance between ventilatory capacity and demand, (ii) the imbalance between energy demand and supply to working respiratory and peripheral muscles, and (iii) the factors that induce peripheral muscle dysfunction. In practice, intolerable exertional symptoms (i.e., dyspnea) and/or leg discomfort are the main symptoms that limit physical performance in patients with chronic lung diseases. Furthermore, the reduced capacity for physical work and the adoption of a sedentary lifestyle, in an attempt to avoid breathlessness upon physical exertion, cause profound muscle deconditioning which in turn leads to disability and loss of functional independence. Accordingly, physical inactivity is an important component of worsening the patients’ quality of life and contributes importantly to poor prognosis. Identifying the factors which prevent a patient with lung disease to easily carry out activities of daily living provides a unique as well as important perspective for the choice of the appropriate therapeutic strategy