Erratum: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study

There was an error in the author list of the published article.Two authors (T Hashempour, Z Hasanshahi) requested to remove from the authors lists. After obtaining the agreement of the authors and the corresponding author, Editor-in-Chief accept the corrections as listed below.The correct author list is:Behzad Dehghani, Iraj Rasooli We apologize for any inconvenience this may have caused. Erratum for:Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico studyB Dehghani, T Hashempour, Z Hasanshahi, I RasooliJ Curr Biomed Rep. 2020; 1(1): 9-16

Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico study

InvH is an indispensable part of T3SS-I and has a significant role in SPI-I mediated effector protein translocation. The InvH mutations have significant effects including reduced secretory and inflammatory responses that result from preventing the normal secretion of several proteins. Our team previous studies showed the capable ability of InvH to induce the humoral immune system to prevent almost all Salmonella strains infections. The current study aimed to determine all aspects of this protein using several bioinformatics tools and find the differences among all Salmonella strains. This data could pave the way for further studies about InvH protein and the production of an effective vaccine against Salmonella infections. InvH sequences for all Salmonella strains were obtained from GenBank and analyzed to determine physicochemical properties, B-Cell and T-Cell epitopes, and reliable structures. Results showed some minimal differences among Salmonella strains. B-Cell and T-Cell epitopes predicted by numerous software approved the ability of this protein to induce both humoral and cellular immune systems remarkably. This study provided a comprehensive data to determine all features of InvH protein and our results showed the ability of this protein to design a capable vaccine and the effect of amino acid changes on structure and physico-chemical properties, and epitopes.  Erratum in:Erratum: Immunogenicity, antigenicity and epitope mapping of Salmonella InvH protein: An in silico studyB Dehghani, I RasooliJ Curr Biomed Rep. 2020; 1(2): 81

Protective response against <i>Acinetobacter baumannii</i> with ferric iron receptors HemTR-BauA in a murine sepsis model

Aim: Iron uptake and metabolism pathways are promising targets in vaccine development as an alternative strategy for antibiotics. Methods &amp; methods: HemTR, a putative heme receptor of Acinetobacter baumannii, was expressed and its protectivity against A. baumannii was determined singly or in combination with the siderophore receptor, BauA, in mice. Results: High level of IgG was elicited. There was a delay in mice mortality with reduced bacterial loads in internal organs in the sublethal challenge. Protection was better in the HemTR-BauA group in both lethal and sublethal challenges. Passive transfer of anti-HemTR and anti-BauA partially protected mice against A. baumannii infection. Conclusion: HemTR in combination with other iron receptors could contribute to the development of protective vaccines against A. baumannii. </jats:p