Byzanz und der Westen : Studien zur Kunst des europäischen Mittelalters /

"Vorgelegt von w.M. Herbert Hunger in der Sitzung am 23. Juni 1982"--Title page verso.Includes bibliographical references.L'asymetrie des relations de Byzance et de l'Occident dans le domaine des arts au moyen âge / André Grabar -- A Byzantine hagiographer at work : Leontios of Neapolis / Cyril Mango -- "Roma" and "Constantinople" in Vienna / Anthony Cutler -- Kunst oder Objekt-Stil? : Fragen zur Funktion der "Kunst" in der "Makedonischen Renaissance" / Hans Belting -- A Greek New Testament manuscript in the Escorial LIbrary : its miniatures and its binding / Hugo Buchthal -- The descent of the dove : observations on the mosaic of the Annunciation in the Cappella Palatina in Palermo / Ernst Kitzinger -- The Madrid manuscript of the Chronicle of Skylitzes in the light of its new dating / Ihor Ševčenko -- Zum Werk eines venezianischen Malers auf dem Sinai / Otto Demus -- Crusader icons and maniera greca / Kurt Weitzmann -- The wall paintings of the Church of the Panagia at Moutoullas, Cyprus / Doula Mouriki

A crucial role of β1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of β1 integrins in keratinocytes in vitro and during cutaneous wound repair. Flow cytometry of cultured β1-deficient keratinocytes confirmed the absence of β1 integrins and showed downregulation of α6β4 but not of αv integrins. β1-null keratinocytes were characterised by poor adhesion to various substrates, by a reduced proliferation rate and by a strongly impaired migratory capacity. In vivo, the loss of β1 integrins in keratinocytes caused a severe defect in wound healing. β1-null keratinocytes showed impaired migration and were more densely packed in the hyperproliferative epithelium. Surprisingly, their proliferation rate was not reduced in early wounds and even increased in late wounds. The failure in re-epithelialisation resulted in a prolonged inflammatory response, leading to dramatic alterations in the expression of important wound-regulated genes. Ultimately, β1-deficient epidermis did cover the wound bed, but the epithelial architecture was abnormal. These findings demonstrate a crucial role of β1 integrins in keratinocyte migration and wound re-epithelialisation. Movies available on-line</jats:p