Percepção dos familiares de estressores nas suas relações decorrentes das demandas de cuidado de crianças e adolescentes dependentes de tecnologia

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Enfermage

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

RACIONALIZAÇÃO DAS AÇÕES DE CONTROLE INTERNO E AUDITORIA COMO PROCESSO DE CONTROLE NA GESTÃO DA SAÚDE EM UNIDADES HOSPITALARES NO CONTEXTO BRASILEIRO

O presente artigo tem como objetivo descrever sucintamente a racionalizaçãodas ações de controle interno e auditoria nas gerências das unidades hospitalares no contexto brasileiro. A necessidade de mecanismos de gestão com implantação de auditagem derivou da necessidade de controles internos para melhoria contínua na gestão hospitalar, como resultado de um processo derivado da universalização proposta na regulação jurídica, garantindo a universalização do acesso, destacando uma clara orientação para estabelecimento de metas quantitativas e qualitativas. Elaborou-se brevehistórico da implantação e da implementação de práticas gerenciais no sistema de saúde brasileiro, a racionalização, resultante de políticas públicas que são monitoradas por padrões de desempenho com resultados vinculados ao planejamento e cumprimento de metas almejadas. Neste sentido, observou-se que, no sistema de saúde pública ou privada, as variadas formas de organização hospitalar têm como claro resultado a transparência dos processos – elementos preponderantes para efetivação da prática de auditagem interna e externa nas unidades hospitalares no contexto brasileiro

The maternity philosophy of the University Hospital at the Federal University of Santa Catarina, Brazil from the perspective of its users, professionals, and academics: preview note

This study is a quantitative investigation of an exploratory-descriptive nature. Its objective is to evaluate the implementation of the maternity philosophy in a university hospital, under the perspective of its professionals, academics, and users. The data are being collected by self-responding forms, applied among the professionals and with nursing and medical students, as well as through interviews with the pregnant women and their partners. The information obtained is being organized by the EPI INFO program. In the current stage of the research, the data referring to 80 nursing professionals have already been obtained and analyzed, showing that for these subjects the principles which guide maternity care are amply known, with the most valued being related to integral care to its users