La política del federalismo fiscal del régimen panista en México: El caso del seguro popular (2000-2012)

Además, el conocimiento científico de las estrategias políticas utilizadas en el federalismo fiscal mexicano será útil para diseñar políticas públicas que eviten más eficazmente las prácticas que condicionan seriamente la libertad de los ciudadanos mexicanos al elegir a sus respectivos representantes políticos, y por tanto, también para la construcción de una democracia más libre, justa, y equitativa en nuestro país.El uso estratégico de los recursos públicos, ya sea en Estados federales o centrales, puede convertirse en una herramienta muy efectiva para sostener regímenes autoritarios o para mantener en el poder a ciertos partidos políticos dentro de regímenes democráticos, ya posean estos últimos sistemas de gobierno presidenciales, parlamentarios, semi parlamentarios o semi presidenciales. En efecto, el uso estratégico de los recursos públicos es un factor que impacta a los resultados electorales y afecta seriamente a un régimen democrático; este uso puede convertirse, en realidad, en un obstáculo formidable para consolidar un régimen democrático, debido a que la distribución estratégica de recursos públicos, en contraste con una justa y equitativa, condiciona seriamente la libertad de los ciudadanos para tomar decisiones políticas, y así, al final, beneficia o perjudica, según sea el caso, a determinados actores políticos

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor

Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging. Because native GLP-1 is degraded rapidly by dipeptidyl peptidase-IV (DPP-IV), a more stable agonist of GLP-1 such as Exendin-4 is a preferred imaging agent. In this study, DO3A-VS-Cys^(40)-Exendin-4 was prepared through the conjugation of DO3A-VS with Cys^(40)-Exendin-4. The in vitro binding affinity of DO3A-VS-Cys^(40)-Exendin-4 was evaluated in INS-1 cells, which overexpress GLP-1R. After ^(64)Cu labeling, biodistribution studies and microPET imaging of ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 were performed on both subcutaneous INS-1 tumors and islet transplantation models. The subcutaneous INS-1 tumor was clearly visualized with microPET imaging after the injection of ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4. GLP-1R positive organs, such as pancreas and lung, showed high uptake. Tumor uptake was saturable, reduced dramatically by a 20-fold excess of unlabeled Exendin-4. In the intraportal islet transplantation models, ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 demonstrated almost two times higher uptake compared with normal mice. ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 demonstrated persistent and specific uptake in the mouse pancreas, the subcutaneous insulinoma mouse model, and the intraportal human islet transplantation mouse model. This novel PET probe may be suitable for in vivo pancreatic islets imaging in the human

Examining the 2005 Ethiopian Parliamentary Election Results Under Alternative Electoral Rules

As many scholars have noted, electoral systems exert a powerful influence on the process of democratization (Taagepera and Shugart, 1989; Horowitz, 1985; Ishiyama 1997). Indeed first competitive or “transitional” elections are crucial moments for newly democratizing countries. Although these elections mark only a beginning point in an often arduous journey, their outcomes crucially affect the future course of democratic transition and democratic consolidation (Olsen 1993; Schmitter 1992; Bermeo, 1987). Indeed, whoever wins the transitional election often has the opportunity to re-write the rules of the game to their advantage and, hence, significantly influence future political developments

Electoral Systems, Ethnic Fragmentation and Party Systems Volatility in 31 Sub Saharan African Countries

This paper thus addresses two primary issues. What is the relationship between the types of electoral systems that have been used to govern initial elections in the democratizing states of Africa and the degree to which party systems volatility has emerged? What other factors impact on the levels of volatility? I examine the above questions using data from 31 African countries. I find that most of the factors often cited as impacting on party systems development do not account for the level of legislative volatility. However, the dominance of the ruling party in the first election following democratic transition does impact the extent of legislative volatility later. Nonetheless these cases are also less likely to lead to democratic or politically stable outcomes

Central Asia and the globalisation of the contemporary legal consciousness

What is the logic which governs the processes of legal globalization? How does the transnational proliferation of legal forms operate in the contemporary geo-juridical space? What are the main defining characteristics of the currently dominant mode of transnational legal consciousness and how can the concept of legal consciousness help us understand better the historical ebb and flow of the Western-led projects of good governance promotion in regions like Central Asia after the fall of the Soviet Union? Using Duncan Kennedy’s seminal essay Three Globalizations of Law and Legal Thought as its starting platform, this essay seeks to explore these and a series of other related questions, while also drawing on the work of the Greek Marxist lawyer-philosopher Nicos Poulantzas to help elucidate some latent analytical stress-points in Kennedy’s broader theoretical framework. Reacting against the neo-Orientalist tone adopted across much of the contemporary field of Central Asian studies, it develops an alternative account of the internal history of the legal-globalizational encounter between the Western-based reform entrepreneurs and the national legal-political elites in Central Asia in the post-1991 period, complementing it with a detailed description of the general institutional and discursive structures within which this encounter took place

“A very orderly retreat”: Democratic transition in East Germany, 1989-90

East Germany's 1989-90 democratisation is among the best known of East European transitions, but does not lend itself to comparative analysis, due to the singular way in which political reform and democratic consolidation were subsumed by Germany's unification process. Yet aspects of East Germany's democratisation have proved amenable to comparative approaches. This article reviews the comparative literature that refers to East Germany, and finds a schism between those who designate East Germany's transition “regime collapse” and others who contend that it exemplifies “transition through extrication”. It inquires into the merits of each position and finds in favour of the latter. Drawing on primary and secondary literature, as well as archival and interview sources, it portrays a communist elite that was, to a large extent, prepared to adapt to changing circumstances and capable of learning from “reference states” such as Poland. Although East Germany was the Soviet state in which the positions of existing elites were most threatened by democratic transition, here too a surprising number succeeded in maintaining their position while filing across the bridge to market society. A concluding section outlines the alchemy through which their bureaucratic power was transmuted into property and influence in the “new Germany”

What are the Effects of Large-scale Violence on Social and Institutional Trust? Using the Civil War Literature to Understand the Case of Mexico, 2006–2012

Artículo científico en co autoría, publicado en inglés en la Revista Civil Wars, indizada a nivel internacional.El presente trabajo explora el impacto de la violencia de la delincuencia organizada en la confianza ciudadana, principalmente a nivel municipal de México. A través de un análisis multinivel, no se encontraron evidencias concluyentes de una correlación fuerte entre los niveles de violencia organizada a nivel municipal en México y la confianza ciudadana. No obstante, si se detectó una correlación significativa entre la percepción de inseguridad pública y la confianza ciudadana, empero, esta correlación es independiente de la violencia real experimentada.No aplic

Dynamic Molecular Markers of Otosclerosis in the Human Cochlea.

OBJECTIVE: To investigate the role and distribution of various molecular markers using immunohistochemistry and immunofluorescence to further elucidate and understand the pathogenesis of otosclerosis. METHODS: Archival celloidin formalin-fixed 20-micron thick histologic sections from 7 patients diagnosed with otosclerosis were studied and compared to controls. Sections in the mid-modiolar region were immunoreacted with rabbit polyclonal antibodies against nidogen-1, β2-laminin, collagen-IX, BSP, and monoclonal antibodies against TGF β-1 and ubiquitin. Digital images were acquired using a high-resolution light and laser confocal microscope. RESULTS: Nidogen-1, BSP, and collagen-IX were expressed in the otospongiotic regions, and to lesser extent, in the otosclerotic regions, the latter previously believed to be inactive. β2-laminin and ubiquitin were uniformly expressed in both otospongiotic and otosclerotic regions. There was a basal level of expression of all of these markers in the normal hearing and sensorineural hearing loss specimens utilized as control. TGF β -1, however, though present in the otosclerosis bones, was absent in the normal hearing and sensorineural hearing loss controls. CONCLUSIONS: Our results propose that the activity and function of TGF-1 may play a key role in the development and pathogenesis of otosclerosis. Further studies utilizing a higher number of temporal bone specimens will be helpful for future analysis and to help decipher its role as a potential target in therapeutic interventions