Cluster Approximation for the Farey Fraction Spin Chain

We consider the Farey fraction spin chain in an external field $h$. Utilising ideas from dynamical systems, the free energy of the model is derived by means of an effective cluster energy approximation. This approximation is valid for divergent cluster sizes, and hence appropriate for the discussion of the magnetizing transition. We calculate the phase boundaries and the scaling of the free energy. At $h=0$ we reproduce the rigorously known asymptotic temperature dependence of the free energy. For $h \ne 0$, our results are largely consistent with those found previously using mean field theory and renormalization group arguments.Comment: 17 pages, 3 figure

On the spectrum of Farey and Gauss maps

In this paper we introduce Hilbert spaces of holomorphic functions given by generalized Borel and Laplace transforms which are left invariant by the transfer operators of the Farey map and its induced version, the Gauss map, respectively. By means of a suitable operator-valued power series we are able to study simultaneously the spectrum of both these operators along with the analytic properties of the associated dynamical zeta functions.Comment: 23 page

Sirtuin-3 Is Expressed by Enteric Neurons but It Does not Play a Major Role in Their Regulation of Oxidative Stress

Gut inflammation contributes to the development of gut motility disorders in part by disrupting the function and survival of enteric neurons through mechanisms that involve oxidative stress. How enteric neurons regulate oxidative stress is still poorly understood. Importantly, how neuron autonomous antioxidant mechanisms contribute to the susceptibility of enteric neurons to oxidative stress in disease is not known. Here, we discover that sirtuin-3 (Sirt3), a key regulator of oxidative stress and mitochondrial metabolism, is expressed by neurons in the enteric nervous system (ENS) of the mouse colon. Given the important role of Sirt3 in the regulation of neuronal oxidative stress in the central nervous system (CNS), we hypothesized that Sirt3 plays an important role in the cell autonomous regulation of oxidative stress by enteric neurons and that a loss of Sirt3 increases neuronal vulnerability during intestinal inflammation. We tested our hypothesis using a combination of traditional immunohistochemistry, oxidative stress measurements and in vivo and ex vivo measures of GI motility in healthy and inflamed wild-type (wt) and Sirt3 null (Sirt3(−/−)) mice. Our results show that Sirt3 is widely expressed by neurons throughout the myenteric plexus of the mouse colon. However, the deletion of Sirt3 had surprisingly little effect on gut function and susceptibility to inflammation. Likewise, neither the genetic ablation of Sirt3 nor the inhibition of Sirt3 with antagonists had a significant effect on neuronal oxidative stress. Therefore, we conclude that Sirt3 contributes very little to the overall regulation of neuronal oxidative stress in the ENS. The functional relevance of Sirt3 in enteric neurons is still unclear but our data show that it is an unlikely candidate to explain neuronal vulnerability to oxidative stress during inflammation

Charming penguins in B => K* pi, K (rho,omega,phi) decays

We evaluate the decays B => K* pi, K (rho,omega,phi) adding the long distance charming penguin contributions to the short distance: Tree+Penguin amplitudes. We estimate the imaginary part of the charming penguin by an effective field theory inspired by the Heavy Quark Effective Theory and parameterize its real part. The final results for branching ratios depend on only two real parameters and show a significant role of the charming penguins. The overall agreement with the available experimental data is satisfactory.Comment: 13 pages, 1 figur

On the characterisation of paired monotone metrics

Hasegawa and Petz introduced the notion of dual statistically monotone metrics. They also gave a characterisation theorem showing that Wigner-Yanase-Dyson metrics are the only members of the dual family. In this paper we show that the characterisation theorem holds true under more general hypotheses.Comment: 12 pages, to appear on Ann. Inst. Stat. Math.; v2: changes made to conform to accepted version, title changed as wel

Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016

In Italy, B and C are the predominant serogroups among meningococci causing invasive diseases. Nevertheless, in the period from 2013 to 2016, an increase in serogroup W Neisseria meningitidis (MenW) was observed. This study intends to define the main characteristics of 63 MenW isolates responsible of invasive meningococcal disease (IMD) in Italy from 2000 to 2016. We performed whole genome sequencing on bacterial isolates or single gene sequencing on culturenegative samples to evaluate molecular heterogeneity. Our main finding was the cocirculation of the Hajj and the South American sublineages belonging to MenW/ clonal complex (cc)11, which gradually surpassed the MenW/cc22 in Italy. All MenW/cc11 isolates were fully susceptible to cefotaxime, ceftriaxone, ciprofloxacin, penicillin G and rifampicin. We identified the fulllength NadA protein variant 2/3, present in all the MenW/cc11. We also identified the fHbp variant 1, which we found exclusively in the MenW/cc11/Hajj sublineage. Concern about the epidemic potential of MenW/cc11 has increased worldwide since the year 2000. Continued surveillance, supported by genomic characterisation, allows high-resolution tracking of pathogen dissemination and the detection of epidemicassociated strains

Hard X-ray flux from low-mass stars in the Cygnus OB2 Association

Context. The Cygnus OB2 association, the central engine of the Cygnus X star-forming region, is the subject of an extensive INTEGRAL Key Project that will accumulate 6Ms of observations. Analysis of 2Ms of observations by De Becker and co-workers provides the most sensitive limit yet obtained on hard X-ray emission from the cluster. Aims. We investigate the X-ray emission in the 20-40 keV band expected from the flaring low-mass stellar population in Cygnus OB2. We discuss whether such emission needs to be considered in the interpretation of existing and future X-ray observations of the region, and whether such observations might provide insight into the high-energy processes on low-mass pre-main sequence stars. Methods. The total hard X-ray flux from low-mass stars is estimated by assuming the observed soft X-ray emission stems from a superposition of flares. We further assume the ratio of hard X-ray to soft X-ray emission is described by a scaling found for solar flares by Isola and co-workers. Results. We estimate the low-mass stellar hard X-ray flux in the 20-40 keV band to lie in the range ~2x10^31-6x10^32 erg/s and discuss some potential biases that might affect this result. Conclusions. Hard X-ray emission could lie at a level not much below the current observed flux upper limits for Cygnus OB2. If this emission could be detected, it would provide insight into the hard X-ray production of large flares on pre-main sequence stars. We highlight the penetrating power of hard X-rays from low-mass stellar populations as a possible pointer to our Galaxy's hidden star-forming clusters and super-clusters using more sensitive observations from future missions.Comment: 5 page

VGF peptide profiles in Type 2 diabetic patients' plasma and in obese mice

To address the possible involvement of VGF peptides in obesity and diabetes, we studied type 2 diabetes (T2D) and obese patients, and high-fat diet induced obese mice. Two VGF peptides (NAPP-19 and QQET-30) were identified in human plasma by HPLC-ESI-MS. The VGF C-terminus, the above two cleaved peptides, and the TLQP-21 related peptide/s were studied using ELISA and immunohistochemistry. In euglycemic patients, plasma NAPPE and TLQP like peptides were significantly reduced with obesity (74±10 vs. 167±28, and 92±10 vs. 191±19 pmol/ml, mean+SEM, n = 10 and 6, obese vs. normal BMI, respectively, p<0.03). Upon a standard glucose load, a distinct response was shown for VGF C-terminus, TLQP and QQET-like (ERVW immunoreactive) peptides in euglycemic normal BMI patients, but was virtually abolished in euglycemic obese, and in T2D patients independently of BMI. High-fat diet induced obese mice showed reduced plasma VGF C-terminus, NAPPE and QQET-like (ERVW) peptide/s (3±0.2 vs. 4.6±0.3, 22±3.5 vs. 34±1.3, and 48±7 vs. 100±7 pmol/ml, mean+SEM, n = 8/group, obese vs. slim, respectively, p<0.03), with a loss of the response to glucose for all VGF peptides studied. In immunohistochemistry, TLQP and/or VGF C-terminus antibodies labelled VGF containing perikarya in mouse celiac ganglia, pancreatic islet cells and thin beaded nerve fibres in brown adipose tissues, with fewer in white adipose tissue. Upon the glucose load, tyrosine hydroxylase and VGF C-terminus immunoreactive axons became apparent in pancreatic islets of slim animals, but not in obese animals. Alltogether, a significant loss of VGF peptide immunoreactivity and/or their response to glucose was demonstrated in obese patients, with or without T2D, in parallel with a similar loss in high-fat diet induced obese mice. An involvement of VGF in metabolic regulations, including those of brown and/or white adipose tissues is underlined, and may point out specific VGF peptides as potential targets for diagnosis and/or treatment

Testing QCD factorisation and charming penguins in charmless B→PV{\boldsymbol{B\to PV}}

We try a global fit of the experimental branching ratios and CP-asymmetries of the charmless $B\to PV$ decays according to QCD factorisation. We find it impossible to reach a satisfactory agreement, the confidence level (CL) of the best fit is smaller than .1 %. The main reason for this failure is the difficulty to accomodate several large experimental branching ratios of the strange channels. Furthermore, experiment was not able to exclude a large direct CP asymmetry in $\bar {B^0}\to\rho^+ \pi^-$, which is predicted very small by QCD factorisation. Trying a fit with QCD factorisation complemented by a charming-penguin inspired model we reach a best fit which is not excluded by experiment (CL of about 8 %) but is not fully convincing. These negative results must be tempered by the remark that some of the experimental data used are recent and might still evolve significantly.Comment: 21 pages, 4 figures; several typos corrected, added one footnote and two references, comments added about PQCD. To appear in Phys.Rev.