What is the Cost of Venting? Evidence from eBay

This paper uses data collected from eBay's website to identify why buyers fail to leave (negative) feedback in online markets. Empirical results con¯rm that the fear of retaliation may be an important motivation for buyers not to leave (negative) feedback, while the time and effort cost of reporting may be not.reputation, feedback, asymmetric information

Money Talks? An Experimental Study of Rebate in Reputation System Design

Reputation systems that rely on feedback from traders are important institutions for helping sustain trust in markets, while feedback information is usually considered a public good. We apply both theoretical models and experiments to study how raters' feedback behavior responds to different reporting costs and how to improve market efficiency by introducing a pre-commitment device for sellers in reputation systems. In particular, the pre-commitment device we study here allows sellers to provide rebates to cover buyers' reporting costs before buyers make purchasing decisions. Using a buyer-seller trust game with a unilateral feedback scheme, we find that a buyer’s propensity to leave feedback is more sensitive to reporting costs when the seller cooperates than when the seller defects. The seller’s decision on whether to provide a rebate significantly affects the buyer’s decision to leave feedback by compensating for the feedback costs. More importantly, the rebate decision has a significant impact on the buyer's purchasing decision via signaling the seller's cooperative type. The experimental results show that the rebate mechanism improves the market efficiency.reputation, trust, feedback mechanism, asymmetric information, public goods, experimental economics

A Dollar for Your Thoughts: Feedback-Conditional Rebates on eBay

We run a series of controlled field experiments on eBay where buyers are rewarded for providing feedback. Our results suggest that the feedback rate increases when a rebate is given, though the effect is small. Moreover, the nature of buyer feedback is influenced by rewards: buyers are more likely to give positive feedback following a high-quality transaction (fast shipping) and less likely to give negative feedback following a low-quality transaction (slow shipping). In sum, you can buy feedback but you cannot buy unbiased feedback

The Local Volume HI Survey: star formation properties

We built a multi-wavelength dataset for galaxies from the Local Volume HI Survey (LVHIS), which comprises 82 galaxies. We also select a sub-sample of ten large galaxies for investigating properties in the galactic outskirts. The LVHIS sample covers nearly four orders of magnitude in stellar mass and two orders of magnitude in HI mass fraction (fHI). The radial distribution of HI gas with respect to the stellar disc is correlated with fHI but with a large scatter. We confirm the previously found correlations between the total HI mass and star formation rate (SFR), and between HI surface densities and SFR surface densities beyond R25. However, the former correlation becomes much weaker when the average surface densities rather than total mass or rate are considered, and the latter correlation also becomes much weaker when the effect of stellar mass is removed or controlled. Hence the link between SFR and HI is intrinsically weak in these regions, consistent with what was found on kpc scales in the galactic inner regions. We find a strong correlation between the SFR surface density and the stellar mass surface density, which is consistent with the star formation models where the gas is in quasi-equilibrium with the mid-plane pressure. We find no evidence for HI warps to be linked with decreasing star forming efficiencies.Comment: 31 pages, 20 figures, 4 tables. Accepted for publication at MNRA

Confucian Principles: A Study of Chinese Americans’ Interpersonal Relationships in Selected Children’s Picturebooks

[[abstract]]There has not been enough critical analysis of children’s literature by and about Chinese Americans, especially when compared to other minority groups in the United States. In particular, Chinese American historical books lack extensive analysis. It is important to reflect cultural accuracy in literature and to help children develop clear concepts of self and others by providing precise cultural and physical characteristics of people. While cultural authenticity allows children the opportunity to see a reflection of real experiences within a book instead of seeing stereotypes or misrepresentations, obtaining correct information about a certain time period can help children to see images of immigration accurately represented in literature. Using the Confucian delineation of interpersonal relationships as the major criterion of cultural authenticity, this article examines three currently available children’s picturebooks set in the historical period between 1848 and 1885. In addition to exploring how Chinese Americans’ interpersonal relationships are portrayed in these children’s historical books, this article argues for more proactive inclusion of the diversity in selection of picturebooks.[[notice]]補正完

Foxc1 is required by pericytes during fetal brain angiogenesis

Summary Brain pericytes play a critical role in blood vessel stability and blood–brain barrier maturation. Despite this, how brain pericytes function in these different capacities is only beginning to be understood. Here we show that the forkhead transcription factor Foxc1 is expressed by brain pericytes during development and is critical for pericyte regulation of vascular development in the fetal brain. Conditional deletion of Foxc1 from pericytes and vascular smooth muscle cells leads to late-gestation cerebral micro-hemorrhages as well as pericyte and endothelial cell hyperplasia due to increased proliferation of both cell types. Conditional Foxc1 mutants do not have widespread defects in BBB maturation, though focal breakdown of BBB integrity is observed in large, dysplastic vessels. qPCR profiling of brain microvessels isolated from conditional mutants showed alterations in pericyte-expressed proteoglycans while other genes previously implicated in pericyte–endothelial cell interactions were unchanged. Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis)

“I should” vs. “I would” in International Graduate Students’ Positioning as Global Talents

[EN] This mixed-methods study explores the transformative journey of international graduate students as educated newcomers, inspiring them to establish their presence in a new professional market. Focused on the personal, social, professional, and emotional dimensions of the BE-EDGE Model for students’ investment in their boutique employability, the research unveils the nuanced needs of international students through surveys and focus groups. Findings reveal the dichotomy between aspirational "I should" and preferential "I would rather" mindsets. The study arrives at the design for a Center for Global Talents that can provide international students with a holistic platform and ecosystem for empowering individuals to shift from introspection and reluctance to integration and proactive engagement and establish their position as powerful contributors of diversity, customization, belonging, and meaning required for a future of work.Park, J.; Li, L.; Ivy, J. (2024). “I should” vs. “I would” in International Graduate Students’ Positioning as Global Talents. Editorial Universitat Politècnica de València. https://doi.org/10.4995/HEAd24.2024.1722

India Global Immersion 2018

Undergraduate Clinical/ Cultural Immersion in New Delhi, India 2018https://deepblue.lib.umich.edu/bitstream/2027.42/148305/1/LiLeeNguyen.pd

Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers.

PURPOSE: Multiple cancers harbor genetic aberrations that impact AKT signaling. MK-2206 is a potent pan-AKT inhibitor with a maximum tolerated dose (MTD) previously established at 60 mg on alternate days (QOD). Due to a long half-life (60-80 hours), a weekly (QW) MK-2206 schedule was pursued to compare intermittent QW and continuous QOD dosing. EXPERIMENTAL DESIGN: Patients with advanced cancers were enrolled in a QW dose-escalation phase I study to investigate the safety and pharmacokinetic-pharmacodynamic profiles of tumor and platelet-rich plasma (PRP). The QOD MTD of MK-2206 was also assessed in patients with ovarian and castration-resistant prostate cancers and patients with advanced cancers undergoing multiparametric functional magnetic resonance imaging (MRI) studies, including dynamic contrast-enhanced MRI, diffusion-weighted imaging, magnetic resonance spectroscopy, and intrinsic susceptibility-weighted MRI. RESULTS: A total of 71 patients were enrolled; 38 patients had 60 mg MK-2206 QOD, whereas 33 received MK-2206 at 90, 135, 150, 200, 250, and 300 mg QW. The QW MK-2206 MTD was established at 200 mg following dose-limiting rash at 250 and 300 mg. QW dosing appeared to be similarly tolerated to QOD, with toxicities including rash, gastrointestinal symptoms, fatigue, and hyperglycemia. Significant AKT pathway blockade was observed with both continuous QOD and intermittent QW dosing of MK-2206 in serially obtained tumor and PRP specimens. The functional imaging studies demonstrated that complex multiparametric MRI protocols may be effectively implemented in a phase I trial. CONCLUSIONS: Treatment with MK-2206 safely results in significant AKT pathway blockade in QOD and QW schedules. The intermittent dose of 200 mg QW is currently used in phase II MK-2206 monotherapy and combination studies (NCT00670488).This study was supported by Merck & Co., Inc. The Drug Development Unit of the Royal Marsden NHS Foundation Trust and The Institute of Cancer Research is supported in part by a program grant from Cancer Research U.K. Support was also provided by the Experimental Cancer Medicine Centre (to The Institute of Cancer Research), the National Institute for Health Research (NIHR) Biomedical Research Centre (jointly to the Royal Marsden NHS Foundation Trust and The Institute of Cancer Research), the NIHR Clinical Research Facility (to the Royal Marsden NHS Foundation Trust) and the Cancer Research UK and EPSRC Cancer Imaging Centre. T.A. Yap is the recipient of the 2011 Rebecca and Nathan Milikowsky – PCF Young Investigator Award and is supported by the NIHR. M.O. Leach is an NIHR Senior Investigator.This is the accepted manuscript. The final version is available from AACR at http://clincancerres.aacrjournals.org/content/early/2014/09/19/1078-0432.CCR-14-0868